• Thumbnail for Low-affinity nerve growth factor receptor
    The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR...
    37 KB (4,235 words) - 04:17, 19 March 2025
  • Thumbnail for Nerve growth factor
    Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival...
    27 KB (3,118 words) - 10:07, 24 June 2025
  • neurotrophic factor receptors are the p75 and the "Trk" families of tyrosine kinase receptors. p75 is a low affinity neurotrophin receptor, to which all...
    5 KB (670 words) - 10:25, 10 April 2025
  • Thumbnail for Brain-derived neurotrophic factor
    responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). It may...
    50 KB (5,881 words) - 13:31, 5 May 2025
  • agonist of the tropomyosin receptor kinase A (TrkA) and low-affinity nerve growth factor receptor (p75NTR). The most common side effects include eye pain...
    7 KB (397 words) - 20:18, 29 May 2025
  • Thumbnail for Tropomyosin receptor kinase A
    Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming...
    28 KB (3,328 words) - 15:54, 29 October 2024
  • Thumbnail for Epidermal growth factor
    Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
    17 KB (1,716 words) - 11:48, 25 May 2025
  • Thumbnail for Cell surface receptor
    High affinity neurotrophin receptors Ephrin receptors Integrins Low Affinity Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll-like...
    22 KB (2,500 words) - 08:42, 17 June 2025
  • Thumbnail for Neurotrophin-3
    binds a second-receptor type besides Trk receptors, called the LNGFR (for "low affinity nerve growth factor receptor). TrkC is a receptor tyrosine kinase...
    14 KB (1,824 words) - 08:46, 24 June 2025
  • Thumbnail for Tropomyosin receptor kinase C
    is one other NT-3 receptor family besides the Trks (TrkC & TrkB), called the "LNGFR" (for "low affinity nerve growth factor receptor"). As opposed to TrkC...
    30 KB (3,901 words) - 00:12, 24 May 2025
  • Thumbnail for Hepatocyte growth factor receptor
    Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
    59 KB (6,731 words) - 05:32, 23 May 2025
  • Thumbnail for Tropomyosin receptor kinase B
    Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type...
    39 KB (4,393 words) - 05:21, 26 March 2025
  • Thumbnail for Fibroblast growth factor receptor 2
    This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. FGFR2 has important...
    14 KB (1,745 words) - 09:02, 15 July 2024
  • Thumbnail for Neurotrophin
    of receptors for neurotrophins: p75 and the "Trk" family of Tyrosine kinases receptors. Nerve growth factor (NGF), the prototypical growth factor, is...
    28 KB (3,081 words) - 17:29, 23 June 2025
  • Thumbnail for Placental growth factor
    Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor is a member of the VEGF (vascular endothelial...
    15 KB (1,867 words) - 09:38, 20 April 2025
  • Thumbnail for Olfactory ensheathing cell
    OECs have been identified with high or low cell surface expression of low-affinity nerve growth factor receptor (p75). Neuroscience Neuroglia Olfaction...
    18 KB (2,265 words) - 11:14, 18 June 2025
  • Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells...
    40 KB (4,578 words) - 12:30, 10 September 2024
  • sufficient to mediate signaling without the requirement of the Low affinity Nerve Growth Factor receptor (LNGFR). Glass identified the E3 ubiquitin ligases, MuRF1...
    11 KB (1,056 words) - 22:59, 24 May 2025
  • Thumbnail for George Yancopoulos
    receptor for BDNF, and showed that they were sufficient to mediate signaling without the requirement of the Low affinity Nerve Growth Factor receptor...
    26 KB (2,634 words) - 13:07, 26 May 2025
  • Thumbnail for Fibroblast growth factor receptor 3
    Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster...
    17 KB (1,844 words) - 17:02, 8 May 2025
  • Thumbnail for Somatostatin
    Pasireotide is somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. Six somatostatin...
    23 KB (2,531 words) - 13:11, 14 April 2025
  • Thumbnail for GRB2
    Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2...
    82 KB (9,401 words) - 09:01, 24 June 2025
  • Thumbnail for Co-receptor
    into co-receptors for p75, such as the sortilin co-receptor, has implicated sortilin in connection to neurotrophins, a type of nerve growth factor. The p75...
    22 KB (3,129 words) - 14:03, 8 June 2025
  • Thumbnail for Μ-opioid receptor
    The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins...
    49 KB (4,886 words) - 17:42, 18 June 2025
  • Thumbnail for Aryl hydrocarbon receptor
    in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought...
    52 KB (5,999 words) - 06:16, 5 February 2025
  • inhibitory factor receptor Leukocyte extravasation Leukocyte-promoting factor Linear epitope Lipid A Lipopolysaccharide binding protein Low-affinity nerve growth...
    13 KB (1,237 words) - 01:24, 15 January 2024
  • Thumbnail for Acetylcholine
    Acetylcholine (category M1 receptor agonists)
    the presence of ACh, which provides growth and proliferative signals via a membrane-located M1-muscarinic receptor homolog. Partly because of acetylcholine's...
    41 KB (4,393 words) - 17:10, 23 June 2025
  • Thumbnail for NDN (gene)
    has been shown to interact with: E2F1, HNRNPU, IL1A, Low affinity nerve growth factor receptor, NUCB2, and P53 ENSG00000288364 GRCh38: Ensembl release...
    11 KB (1,275 words) - 09:54, 13 March 2025
  • Thumbnail for Prolactin
    cycle-related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor, binding to cytokine-like receptors, it influences hematopoiesis...
    58 KB (6,049 words) - 23:34, 22 May 2025
  • Thumbnail for NMDA receptor
    successful NMDA receptor antagonists for neurodegenerative diseases continued and focused on developing low affinity blockers. However the affinity could not...
    109 KB (12,193 words) - 18:46, 20 June 2025