One way cytosolic DNA is sensed is via the cGAS/STING pathway, specifically by the cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition, cGAS dimerizes...
23 KB (2,894 words) - 15:42, 30 April 2025
Cyclic GMP-AMP synthase (redirect from CGAS enzyme)
interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes...
5 KB (514 words) - 18:35, 23 January 2024
a way to overcome resistance to cancer immunotherapy. CGAS–STING cytosolic DNA sensing pathway GRCh38: Ensembl release 89: ENSG00000183735 – Ensembl,...
21 KB (2,314 words) - 22:22, 15 July 2025
Stimulator of interferon genes (redirect from STING)
role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon...
24 KB (2,749 words) - 08:44, 4 June 2025
IL-18. MtDNA can also be recognized by cyclic GMP-AMP synthase (cGAS), a cytosolic dsDNA sensor to initiate a STING-IRF3-dependent pathway that in turn...
37 KB (4,221 words) - 22:15, 11 July 2025
result in cytosolic DNA that activates the cGAS–STING cytosolic DNA sensing pathway upregulating SASP by induction of interferon type I. cGAS is essential...
44 KB (4,660 words) - 08:21, 15 June 2025
genomic DNA content to the cytoplasm. Exposure of double-stranded DNA to the cytosol activates anti-viral pathways, such as the cGAS-STING cytosolic DNA-sensing...
34 KB (4,006 words) - 18:56, 17 July 2025
Endogenous retrovirus (category Non-coding DNA)
DNA, retroviruses can be sensed by cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING)...
69 KB (8,310 words) - 11:21, 21 February 2025
RIG-I (section Type-1 Interferon Pathway)
Yu P, Miao Z, Li Y, Bansal R, Peppelenbosch MP, Pan Q (January 2021). "cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral...
24 KB (2,964 words) - 09:30, 13 July 2025