A point accepted mutation — also known as a PAM — is the replacement of a single amino acid in the primary structure of a protein with another single...

substitution matrices include the blocks substitution (BLOSUM) and point accepted mutation (PAM) matrices. Both are based on taking sets of high-confidence...

bases. One of the first amino acid substitution matrices, the PAM (Point Accepted Mutation) matrix was developed by Margaret Dayhoff in the 1970s. This matrix...

databases. She originated one of the first substitution matrices, point accepted mutations (PAM). The one-letter code used for amino acids was developed by...

biomedicine Pneumatic artificial muscles, used in artificial limbs Point accepted mutation, a type of similarity matrix in computational biology Positive...

ancestor, mismatches can be interpreted as point mutations and gaps as indels (that is, insertion or deletion mutations) introduced in one or both lineages in...

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain...

BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these...

support (or disprove) the idea of adaptive mutation, at least in microorganisms. The most widely accepted theory of evolution states that organisms are...

A behaviour mutation is a genetic mutation that alters genes that control the way in which an organism behaves, causing their behavioural patterns to change...

(2014) Biased polyphenism in polydactylous cats carrying a single point mutation: the Hemingway model for of digit novelty. Evolutionary Biology, 41...

The breeding also created the hair-mutation breeds, including the Cornish Rex, Sphynx, Peterbald, and blue-point Siamese cat. A description and depiction...

mutations in this gene. Type I and Type II cancers (explained below) tend to have different mutations involved. ARID1A, which often carries a point mutation...

random mutations on an individual solution. A mutation that increases fitness is always accepted. A mutation that lowers fitness is accepted probabilistically...

Opinions vary as to whether this trait might be the result of genetic mutation or merely an instinctive reaction from being picked up as kittens by their...

the body. It is an autosomal recessive disease resulting from various mutations of gene CYP19 (P450arom) which can lead to ambiguous genitalia and delayed...

A splice site mutation is a genetic mutation that inserts, deletes or changes a number of nucleotides in the specific site at which splicing takes place...

of a normal cat's tail. This is the result of a cat body type genetic mutation affecting the tail development, similar to that of a Manx cat. The breed...

pale body. It is an accepted pattern in some cat registries, but not others, for particular breeds (mostly Siamese-related). Point coloration is inherent...

breeds for gangliosidosis 1 and gangliosidosis 2. An autosomal recessive mutation in the GBL1 and HEXB gene respectively is responsible for the conditions...

acid in a protein due to point mutation in the corresponding DNA sequence. It is caused by nonsynonymous missense mutation which changes the codon sequence...

variants originate, de Vries developed a mutation theory that led to a temporary rift between those who accepted Darwinian evolution and biometricians who...

explanation; Darwin was prepared to accept a measure of Lamarckism, while Huxley was comfortable with both sudden (mutational) change and directed (orthogenetic)...

phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed...

effects of two beneficial mutations in the same individual (i.e. sex aids in the spread of advantageous traits) without the mutations having to have occurred...

of the ridge mutation from either parent and thus lack the classic ridged back. The most current research suggests that the ridge mutation is autosomal...

which offered no mechanism for evolution. Mutationism did propose a mechanism, but it was not generally accepted. The modern synthesis a generation later...

tail must not exceed three inches from the point of extension to the tailbone. See also Cat body-type mutation: Tail types Recent scientific studies on...

About 10% of cases are related to inherited genetic risk; women with mutations in the genes BRCA1 or BRCA2 have about a 50% chance of developing the...

technical term for events that shift an allele frequency upward from zero (mutation is the genetic process that converts one allele to another, whereas introduction...