• The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to give a 1,2,3-triazole. Rolf...
    21 KB (2,639 words) - 20:31, 22 July 2024
  • the azide alkyne Huisgen cycloaddition, organic azides react as 1,3-dipoles, reacting with alkynes to give substituted 1,2,3-triazoles. Some azide reactions...
    28 KB (2,857 words) - 13:45, 22 May 2025
  • describe the 1,3-dipolar cycloaddition between an organic azide and an alkyne to generate 1,2,3-triazole). 1,3-dipolar cycloaddition is an important route...
    65 KB (6,396 words) - 07:16, 24 May 2025
  • Thumbnail for Alkyne
    undergo cyclization, e.g. azide alkyne Huisgen cycloaddition to give triazoles. Cycloaddition processes involving alkynes are often catalyzed by metals...
    24 KB (3,193 words) - 03:32, 16 June 2025
  • = +2.71 V) The azide functional group is commonly utilized in click chemistry through copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions...
    19 KB (2,194 words) - 08:17, 24 May 2025
  • chemistry is a bioorthogonal reaction as a variant of an azide-alkyne Huisgen cycloaddition. By eliminating cytotoxic copper catalysts, the reaction proceeds...
    7 KB (878 words) - 17:17, 28 May 2025
  • cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react...
    10 KB (1,024 words) - 23:01, 1 May 2025
  • developed by Carolyn Bertozzi as an activated variant of an azide alkyne Huisgen cycloaddition, based on the work by Karl Barry Sharpless et al. Unlike CuAAC...
    44 KB (5,098 words) - 08:36, 16 March 2025
  • Thumbnail for Karl Barry Sharpless
    under mild conditions; the most successful example is the azide alkyne Huisgen cycloaddition to form 1,2,3-triazoles. As of 2024[update], Sharpless has...
    13 KB (1,067 words) - 02:11, 27 March 2025
  • (2002). "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes". Angewandte Chemie International...
    48 KB (5,449 words) - 15:24, 15 June 2025
  • the Banert cascade or the azide alkyne Huisgen cycloaddition in which an azide and an alkyne undergo a 1,3-dipolar cycloaddition reaction. Under thermal...
    6 KB (482 words) - 04:50, 5 February 2025
  • Cyclooctyne, the smallest isolable cycloalkyne, is able to undergo azide-alkyne Huisgen cycloaddition under mild, physiological conditions in the absence of a copper(I)...
    14 KB (1,564 words) - 16:10, 27 May 2025
  • Thumbnail for Bioconjugation
    ligation with organic azides, copper-catalyzed Huisgen cycloaddition of azides, and strain promoted Huisgen cycloaddition of azides. The nucleophilic lysine...
    43 KB (4,669 words) - 00:31, 25 May 2025
  • reaction Cycloaddition 1,3-Dipolar cycloaddition Azide-alkyne Huisgen cycloaddition Diels–Alder reaction Nitrone-olefin (3+2) cycloaddition Staudinger...
    8 KB (574 words) - 12:46, 7 March 2025
  • Thumbnail for Tris(benzyltriazolylmethyl)amine
    allows for quantitative, regioselective formal Huisgen 1,3-dipolar cycloadditions between alkynes and azides, in a variety of aqueous and organic solvents...
    4 KB (279 words) - 02:00, 22 August 2022
  • Thumbnail for Step-growth polymerization
    group; which is produced by the 1,3-dipolar cycloaddition, also called the azide-alkyne Huisgen cycloaddition. These polymers can take on the form of a...
    28 KB (3,715 words) - 07:02, 8 September 2024
  • structures. Named ring forming reactions include (not exhaustive): Azide-alkyne Huisgen cycloaddition Bischler–Napieralski reaction Bucherer carbazole synthesis...
    2 KB (262 words) - 09:29, 18 November 2024
  • Thumbnail for Morten P. Meldal
    (2002). "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes". Angewandte Chemie International...
    13 KB (839 words) - 21:44, 21 October 2023
  • Thumbnail for Activity-based proteomics
    or an affinity label such as biotin or an alkyne or azide for use with the Huisgen 1,3-dipolar cycloaddition (also known as click chemistry). A major advantage...
    6 KB (589 words) - 20:38, 27 May 2025
  • Thumbnail for Cyclopropylacetylene
    and psychotropic drug efavirenz. It can also be used in the azide-alkyne Huisgen cycloaddition. "Cyclopropylacetylene : density 0.781 g/mL at 25 °C". Sigmaaldrich...
    4 KB (274 words) - 08:14, 28 May 2025
  • Huisgen (1920–2020)  Germany "for development of the 1,3-Dipolar cycloaddition Reaction (Huisgen reaction) and the variant Copper(I)-catalyzed Azide-Alkyne...
    28 KB (359 words) - 04:37, 12 April 2025
  • 1-Decyne (category Alkynes)
    (2002). "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes". Angewandte Chemie International...
    4 KB (237 words) - 06:07, 28 May 2025
  • Hosomi–Sakurai reaction Houben–Fischer synthesis Hudlicky fluorination Huisgen cycloaddition Hunsdiecker reaction, Hunsdiecker–Borodin reaction Hurd-Mori 1,2...
    37 KB (3,428 words) - 16:27, 11 November 2024
  • Thumbnail for Acyl cyanide
    Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Acyltetrazoles from Azides and Acyl Cyanides". Angewandte Chemie...
    3 KB (408 words) - 08:42, 9 October 2022
  • or an affinity label such as biotin or an alkyne or azide for use with the Huisgen 1,3-dipolar cycloaddition (also known as click chemistry). Suicide inhibition...
    8 KB (1,176 words) - 14:14, 19 March 2023
  • chelation-assisted copper-catalyzed azide-alkyne cycloaddition (CuAAC) (refer to Azide-alkyne Huisgen cycloaddition). Two other versions of PRIME labeling...
    7 KB (824 words) - 02:09, 3 December 2024
  • triazole molecule. Clicked peptide polymers are prepared by the azide-alkyne Huisgen cycloaddition also called the click reaction; which is commonly used in...
    4 KB (421 words) - 09:43, 24 August 2023
  • Thumbnail for Ga-68-Trivehexin
    terminal alkyne, and of TRAP with three linkers bearing terminal azides. These components are assembled by means of copper(I) catalyzed alkyne-azide cycloaddition...
    39 KB (3,472 words) - 03:17, 18 June 2025