• fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor...
    25 KB (3,126 words) - 16:03, 10 June 2025
  • The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of...
    8 KB (827 words) - 14:53, 16 April 2025
  • Thumbnail for Fibroblast growth factor 2
    via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was...
    22 KB (2,698 words) - 15:56, 25 May 2025
  • Thumbnail for Fibroblast growth factor receptor 2
    Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2...
    14 KB (1,745 words) - 09:02, 15 July 2024
  • Thumbnail for Fibroblast growth factor receptor 3
    Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster...
    17 KB (1,844 words) - 17:02, 8 May 2025
  • Thumbnail for Fibroblast growth factor 21
    Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast...
    24 KB (3,038 words) - 23:40, 29 November 2024
  • Thumbnail for Fibroblast growth factor 1
    Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1...
    20 KB (2,311 words) - 22:01, 16 July 2024
  • Thumbnail for Fibroblast growth factor 23
    Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate...
    16 KB (1,840 words) - 07:12, 2 November 2024
  • Thumbnail for Fibroblast growth factor receptor 1
    Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome...
    44 KB (5,003 words) - 14:24, 24 February 2025
  • Thumbnail for Fibroblast growth factor 18
    outgrowth of neurites in PC12 cells. FGF18 signals through fibroblast growth factor receptor (FGFR) family, preferentially binding FGFR 3c (followed by...
    16 KB (1,816 words) - 10:07, 9 May 2025
  • Thumbnail for Fibroblast growth factor receptor 4
    Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster...
    10 KB (1,291 words) - 09:08, 15 July 2024
  • Thumbnail for Fibroblast growth factor 8
    repair, and tumor progression. FGF8 signals primarily through fibroblast growth factor receptor 1 (FGFR1) to trigger downstream pathways involved in neural...
    21 KB (2,541 words) - 04:13, 9 June 2025
  • Fibroblast growth factor 5(FGF5) Fibroblast growth factor 6(FGF6) Fibroblast growth factor 7(FGF7) Fibroblast growth factor 8(FGF8) Fibroblast growth...
    10 KB (1,131 words) - 18:45, 6 May 2025
  • Thumbnail for Receptor tyrosine kinase
    Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90...
    28 KB (3,078 words) - 17:48, 25 January 2025
  • Thumbnail for Acanthosis nigricans
    Activation of other growth factor receptors such as fibroblast growth factor receptors or epidermal growth factor receptor can also be responsible. Acanthosis...
    18 KB (1,783 words) - 11:16, 19 April 2025
  • Thumbnail for Fibroblast growth factor receptor-like 1
    Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. The protein encoded by this gene is a member of the...
    6 KB (842 words) - 01:10, 27 January 2024
  • Thumbnail for Epidermal growth factor receptor
    epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family...
    60 KB (6,879 words) - 01:06, 1 March 2025
  • Thumbnail for Pfeiffer syndrome
    Pfeiffer syndrome (category Cell surface receptor deficiencies)
    big toes. Pfeiffer syndrome is caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped into three types:...
    14 KB (1,432 words) - 02:39, 3 January 2025
  • enzymatic activity include: Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme-linked receptors are of this type. Serine/threonine-specific...
    7 KB (350 words) - 03:00, 28 May 2025
  • Thumbnail for Catequentinib
    vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit...
    5 KB (244 words) - 14:26, 24 February 2025
  • Thumbnail for Cell surface receptor
    Adrenergic receptor Olfactory receptors Receptor tyrosine kinases Epidermal growth factor receptor Insulin Receptor Fibroblast growth factor receptors, High...
    22 KB (2,480 words) - 14:02, 24 March 2025
  • Thumbnail for Craniosynostosis
    found in the fibroblast growth factor receptor 3 (FGFR3) and TWIST genes. Fibroblast growth factor and fibroblast growth factor receptors regulate fetal...
    72 KB (7,727 words) - 21:00, 24 February 2025
  • Thumbnail for Paracrine signaling
    fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates...
    45 KB (4,879 words) - 07:05, 7 April 2025
  • Thumbnail for Klotho (biology)
    viz., FGF19 and FGF21) to their fibroblast growth factor receptors, is promoted via their interactions as co-receptors with β-klotho. Loss of β-Klotho...
    38 KB (4,038 words) - 13:10, 25 May 2025
  • Thumbnail for Nintedanib
    targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Ofev was developed by Boehringer...
    36 KB (3,179 words) - 09:31, 8 June 2025
  • cell culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to...
    6 KB (596 words) - 18:46, 25 May 2025
  • Thumbnail for Platelet-derived growth factor
    fibroblast growth factor (FGF) activates a signaling pathway that positively regulates the PDGF receptors in OPCs. PDGF was one of the first growth factors...
    24 KB (2,882 words) - 15:04, 24 May 2025
  • Thumbnail for Crouzon syndrome
    Crouzon syndrome (category Cell surface receptor deficiencies)
    gene on chromosome 10 that controls the body's production of fibroblast growth factor receptor 2 (FGFR2). Crouzon syndrome is named for Octave Crouzon, a...
    12 KB (1,264 words) - 14:16, 24 May 2025
  • Thumbnail for GRB2
    Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2...
    82 KB (9,365 words) - 09:44, 2 March 2025
  • Achondroplasia (category Growth disorders)
    immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that results in its protein being overactive...
    47 KB (4,420 words) - 15:04, 22 May 2025