Flap endonucleases (FENs, also known as 5' durgs in older references) are a class of nucleolytic enzymes that act as both 5'-3' exonucleases and structure-specific...

Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. The protein encoded by this gene removes 5' overhanging "flaps" (or short...

displaces the RNA/DNA initiator primer into a 5′ flap. The FEN1 5’-3’ endonuclease recognizes that the 5’ flap is displaced, and it cleaves, creating a substrate...

In molecular biology, endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain (namely DNA or RNA). Some, such as deoxyribonuclease...

removes the 5' flap generated during long patch BER. This endonuclease shows a strong preference for a long 5' flap adjacent to a 1-nt 3' flap. The yeast...

3'-end, which is an approach generally known as Taq-MAMA. Flap endonuclease (FEN) is an endonuclease that catalyzes structure-specific cleavage. This cleavage...

microhomology regions followed by recruitment of flap structure-specific endonuclease 1 (FEN1) to remove overhanging flaps. This is followed by recruitment of XRCC1–LIG3...

GEN1, Holliday junction 5' flap endonuclease is a protein that in humans is encoded by the GEN1 gene. This gene encodes a member of the Rad2/xeroderma...

produced in the DNA backbone by base pair mismatches. For details see flap endonuclease. There are more than 900 restriction enzymes, some sequence specific...

KH, Lin D, Shen B (2008). "Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers". Mol. Cancer Res. 6 (11): 1710–7...

Final Exit Network (FEN), an American right-to-die advocacy group Flap endonuclease Forsyth–Edwards Notation (FEN) for chess positions Fédération des...

methyltransferase DNA polymerases E2 SUMO-conjugating enzyme E3 ubiquitin ligases Flap endonuclease Helicases Histone acetyltransferase Histone chaperone Histone deacetylase...

the enzymes DNA polymerase family B, the topoisomerase II A, the FLAP endonuclease and the processing factor proliferating cell nuclear antigen. Other...

least a small deletion, so that it is a mutagenic pathway. FEN1, the flap endonuclease in MMEJ, is epigenetically increased by promoter hypomethylation and...

to copy the undamaged strand via translocation. DNA ligase I and Flap endonuclease 1 or the Ligase-III-XRCC1 complex seal the nicks to complete NER....

creating a flap structure. This flap is then cleaved by endonucleases. At the replication fork, the gap in DNA after removal of the flap is sealed by...

nucleotide and another strand with a gap. FAN1 preferentially acts as a 5’ flap endonuclease. This is illustrated in Figure 2, which shows the sequence of substrate...

flap. Pol β can also perform long-patch displacement synthesis. Long-patch synthesis typically inserts 2–10 new nucleotides. Then flap endonuclease removes...

chain 1 pseudogene 3 GEN1 encoding protein GEN1, Holliday junction 5' flap endonuclease GCKR: Glucokinase regulator GFPT1: glutamine—fructose-6-phosphate...

of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities". J. Biol. Chem. 274 (53): 37763–9. doi:10.1074/jbc...

doi:10.1073/pnas.96.17.9491. PMC 22236. PMID 10449720. "Will the 5'→3' flap endonuclease activity of Taq DNA Polymerase degrade primers?". New England Biolabs...

KH, Lin D, Shen B (2008). "Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers". Mol. Cancer Res. 6 (11): 1710–1717...

plasmids that use the rolling circle replication (RCR) mechanism, the RCR endonuclease creates a nick in the genome strand (single stranded viruses) or one...

Wu L, Bohr VA, Hickson ID, Brosh RM (March 2004). "Stimulation of flap endonuclease-1 by the Bloom's syndrome protein". J. Biol. Chem. 279 (11): 9847–56...

fragment Eukaryotic (synthesis in S phase) Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase:...

pathway of fission yeast meiotic recombination in the absence of a DNA flap endonuclease". Genetics. 171 (4): 1499–511. doi:10.1534/genetics.105.046821. PMC 1456079...

Wu L, Bohr VA, Hickson ID, Brosh RM (March 2004). "Stimulation of flap endonuclease-1 by the Bloom's syndrome protein". J. Biol. Chem. 279 (11): 9847–56...

Boulares HA, Yakovlev AG, Smulson ME (2000). "Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis". Madame Curie Bioscience...

fragment Eukaryotic (synthesis in S phase) Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase:...

pathway of fission yeast meiotic recombination in the absence of a DNA flap endonuclease". Genetics. 171 (4): 1499–1511. doi:10.1534/genetics.105.046821. PMC 1456079...