The fragment antigen-binding region (Fab region) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain...

complementary binding sites, called epitopes in antigens and paratopes in antibody. In an antibody, the Fab (fragment, antigen-binding) region is formed from...

therapeutics, the Fc region of immunoglobulins has been engineered to contain an antigen-binding site. This type of antigen-binding fragment is called Fcab...

are composed of two fragments: antigen binding region (Fab region) and the fragment crystallizable region (Fc region). The Fab region is able to bind to...

the latter portion of the endogenous pathway (e.g. proteolysis of antigens for binding to MHC I molecules). While the joint distinction between the two...

cytometry, immunohistochemistry, and as antigen-binding domains of artificial T cell receptors (chimeric antigen receptor). Unlike monoclonal antibodies...

Fab (monomeric binding) or F(ab')2 (dimeric binding). The fragment antigen-binding region, or Fab, is the selective antigen-binding region. An antibody...

partitioned into two antigen-binding fragments (Fab), containing one VL, VH, CL, and CH1 domain each, as well as the crystallisable fragment (Fc), forming the...

specific for a certain antigen or surface component, bind to the pathogen with their Fab region (fragment antigen binding region), their Fc regions point...

contact with the antigen and are involved in binding antigen, while the framework regions support the binding of the CDR to the antigen and aid in maintaining...

the antigen binding region consists of the variable domains of the heavy and light chains (VH and VL). Heavy-chain antibodies can bind antigens despite...

antigen-binding site, is the part of an antibody which recognizes and binds to an antigen. It is a small region at the tip of the antibody's antigen-binding...

resisting. Hinge region portion of antibody structure between the fragment antigen-binding region and the fragment crystallizable region Living hinge a...

Fab: fragment, antigen-binding (one arm) F(ab')2: fragment, antigen-binding, including hinge region (both arms) Fab': fragment, antigen-binding, including...

antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With...

combinatorial approach that engineers the Fc constant region of an immunoglobulin into a novel antigen-binding site. "F-star starts its operations" (PDF). F-Star...

antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells. Predicting which (fragments of) antigens will be presented to the...

between antigen-dependent and antigen-independent categories. These theories consider a specific combination of antigen peptide sequence and the binding groove...

the new ability to target a specific antigen. The receptors are chimeric in that they combine both antigen-binding and T cell activating functions into...

variable fragments (scFv) and Fab fragments also bind to protein L. Despite this wide binding range, protein L is not a universal antibody-binding protein...

"Protein A" after the antigen fraction isolated by Jensen. It has been shown via crystallographic refinement that the primary binding site for protein A...

recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is...

antibodies fragments engineered from the constant region of an antibody (Fc). In naturally occurring antibodies (such as IgGs), the antigen-binding sites are...

Lectins are carbohydrate-binding proteins that are highly specific for sugar groups that are part of other molecules, so cause agglutination of particular...

Human leukocyte antigens (HLA) began as a list of antigens identified as a result of transplant rejection. The antigens were initially identified by categorizing...

these single-stranded binding proteins are a heterotrimeric complex known as replication protein A (RPA). Each Okazaki fragment is preceded by an RNA...

subunits to Fc fragments (made of CH2 region) of IgG or IgM, which has formed a complex with antigens. C4b and C3b are also able to bind to antigen-associated...

scFv, Fab fragments and bispecific antibodies. scFv is the smallest of the recombinant antibody formats, which is capable of antigen binding. They have...

recognize a "non-self" target, such as a pathogen, only after antigens (small fragments of the pathogen) have been processed and presented in combination...

by binding and neutralizing the pro-inflammatory cytokine, TNF-α. Multiple autoimmune disorders are caused by the binding of IgG to self antigens. Since...