G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged...

the G2/M checkpoint transition. Similar to S Phase, G2 experiences a DNA damage checkpoint. The cell is once more examined for sites of DNA damage or incomplete...

cell cycle checkpoints, the other two being the G2-M DNA damage checkpoint and the spindle checkpoint. Originally, Howard Martin Temin showed that chicken...

vulnerable to DNA damage than any other part of the cell cycle. G2 checkpoint checks for damaged DNA and DNA replication completeness. Damage to DNA that occurs...

the damage before continuing to divide. DNA damage checkpoints occur at the G1/S and G2/M boundaries. An intra-S checkpoint also exists. Checkpoint activation...

G2-M DNA damage checkpoint M spindle checkpoint, prevents anaphase onset until all chromosomes are properly attached to the spindle Immune checkpoint...

G2. In particular, the G2 checkpoint arrests cells in G2 in response to DNA damage through inhibitory regulation of CDK1. During mitotic S phase, DNA...

phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response". Mol. Cell. Biol. 24 (20): 9207–20. doi:10.1128/MCB...

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell...

single-stranded DNA tracts is important in initiating the checkpoint pathways downstream of replication damage. Once single-stranded DNA becomes sufficiently...

checkpoints to ensure that damaged or incomplete DNA is not passed on to daughter cells. Three main checkpoints exist: the G1/S checkpoint, the G2/M checkpoint...

purpose for this checkpoint is to check for appropriate cell size and any DNA damage . The second check point is in the G2 phase, this checkpoint also checks...

(Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of the genome is...

needed to replicate DNA are made. After G1, the cells enter S phase during which the DNA is replicated. After S, the cell will enter G2 where the proteins...

regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell...

maintenance of DNA replication fork stability. In response to DNA damage, Chk1 is an important signal transducer for G2/M checkpoint activation. Activation...

CDC2 unable to arrest in G2 in response to DNA damage, indicating the gene product is involved in G2 arrest. M: A mutant screen of budding yeasts with mitotic...

different DNA damage checkpoints, which inhibit the next or maintain the current cell cycle step. There are two main checkpoints, the G1/S and the G2/M, during...

certain types of DNA damage (most notably, UV-irradiation) and several substrates are preferentially ubiquitinated after DNA damage induction. CUL4A's...

two G0/G1 cells has the same total content of DNA and thus the same fluorescence intensity as a single G2/M cell. Unless recognized as such the G0/G1 doublets...

the cell grows, and the S phase, during which DNA is replicated. It is governed by cell cycle checkpoints to ensure cell cycle integrity and the subsequent...

include the G1 and G2 phases, DNA replication or S phase, and the actual process of cell division, mitosis or M phase. During the M phase, the chromosomes...

cells by inducing hyperacetylation and cell cycle arrest at the G2-M DNA damage checkpoint; partially reversing the morphological changes characteristic...

Carpenter PB, Bonner WM, Chen J, Nussenzweig A (Dec 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nature Cell Biology...

are three checkpoints in the cell cycle: the G1/S Checkpoint or the Start checkpoint in yeast; the G2/M checkpoint; and the spindle checkpoint. During G1...

leads to the DNA damage checkpoint activation. The pathway of choice in DNA repair is highly regulated to guarantee that cells in the S/G2 and G1 phase...

Carpenter PB, Bonner WM, Chen J, Nussenzweig A (Dec 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nature Cell Biology...

an un-replicated DNA checkpoint, a spindle assembly checkpoint, a chromosome-segregation checkpoint, and various DNA damage checkpoints. Table 1 below describes...

cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants. BRCC36...

proliferation by induction of G2/M cell cycle arrest; increased phosphorylation of ataxia telangiectasia mutated (ATM), checkpoint kinase 1 (Chk 1), Chk 2;...