Histone-modifying enzymes are enzymes involved in the modification of histone substrates after protein translation and affect cellular processes including...

Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases),...

Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone...

negatively charged phosphate backbone of DNA. Histones may be chemically modified through the action of enzymes to regulate gene transcription. The most common...

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA...

recruit histone modifying enzymes that mark the new histones, contributing to epigenetic memory. In contrast to old H3 and H4, the old H2A and H2B histone proteins...

HDACTooltip histone deacetylase inhibitor that is selective for class I HDACs in humans. HDACs are histone-modifying enzymes that can cause histone deacetylation...

or more ADP-ribose units to the histone, and is involved in the DNA damage response pathway. Histone Modifying Enzymes Constitutive Heterochromatin International...

regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes comprising transactivation domain 9aaTAD and is involved in the...

Gadewal N, Gupta S, Galande S. "Histone H2B". HIstome: A Relational Knowledgebase of Human Proteins and Histone Modifying Enzymes. Nucleic Acids Research. Archived...

information about human histone proteins, their sites of modifications, variants and modifying enzymes, and diseases linked to histone modifications. HISTome2...

eukaryotes, ATP-dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed to accomplish this remodeling...

body of experimental data. Histone Histone-modifying enzymes Jenuwein T, Allis C (2001). "Translating the histone code". Science. 293 (5532): 1074–80. CiteSeerX 10...

September 2020). "Increased stress and altered expression of histone modifying enzymes in brain are associated with aberrant behaviour in vitamin B12...

eukaryotes, ATP dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed to accomplish this remodeling...

curated database of histone variants in humans and associated post-translational modifications as well as modifying enzymes. MS_HistoneDB is a proteomics-oriented...

of addiction, where changes in the expression of histone-modifying enzymes via gene knockout or enzyme inhibition in specific neurons produced alterations...

regulation. Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with "histone acetyltransferase"...

changes to the histone tails act indirectly on the DNA. For example, lysine acetylation may create a binding site for chromatin-modifying enzymes (or transcription...

tighter. This can be done by modifying histones at certain sites by methylation. Histone methyltransferases are enzymes which transfer methyl groups from...

guide or direct protein complexes with chromatin remodeling and/or histone modifying activity to methylated CpG islands. MBD proteins generally repress...

Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone...

outside of the nucleosome. Certain histone modifying enzymes can add or remove functional groups to the histones, and these modifications influence the...

possess histone acetyltransferase activity. p300 and CBP are the most promiscuous histone acetyltransferase enzymes acetylating all four core histones on multiple...

certain cell types. HIstome Histone acetyltransferase Histone deacetylases Histone methyltransferase Histone-Modifying Enzymes Nucleosome PRMT4 pathway Schuettengruber...

Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. The other histone proteins are: H1, H2B...

eukaryotes, ATP dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed to accomplish this remodeling...

well. Inhibitors of class I histone deacetylase (HDAC) enzymes are drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and...

Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones...

R. (2010). "Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes". Proceedings of the National Academy of Sciences. 107 (50): 21499–21504...