The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human...
24 KB (2,617 words) - 19:43, 7 August 2022
pseudogenes. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR)...
25 KB (3,053 words) - 17:04, 11 July 2025
interferon-alpha/beta receptor interferon-gamma receptor Interferon type III receptor Interleukin-10 receptor Interleukin-20 receptor Interleukin-22 receptor Interleukin-28...
6 KB (616 words) - 00:02, 30 March 2025
Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). It is produced by mammalian...
32 KB (2,851 words) - 23:22, 16 August 2024
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. The protein encoded by this gene is a type I membrane...
11 KB (1,344 words) - 04:17, 15 July 2025
JA, Smith GL (December 2000). "The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral...
63 KB (7,124 words) - 04:51, 12 July 2025
Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene. The protein encoded by this gene is a type I membrane...
11 KB (1,400 words) - 21:49, 15 July 2025
Immunodeficiency (X-SCID). Type II cytokine receptors, whose members are receptors mainly for interferons. Immunoglobulin (Ig) superfamily, which are...
6 KB (442 words) - 18:18, 21 May 2025
to Interferon-alpha/beta receptor of nearby cells to protect cells from local infection. STING elicits powerful type I interferon immunity against viral...
24 KB (2,749 words) - 08:44, 4 June 2025
The interferon-gamma receptor (IFNGR) protein complex is the heterodimer of two chains: IFNGR1 and IFNGR2. It binds interferon-γ, the sole member of interferon...
8 KB (870 words) - 23:14, 28 May 2024
PTEN-Akt-FOXO axis (suppressive) and the leukemia inhibitory factor receptor beta (LIFRbeta)-STAT3 signaling pathway (oncogenic) was shown. Overactivation...
29 KB (3,485 words) - 06:51, 2 June 2025
heterodimeric receptor consisting of Interferon gamma receptor 1 (IFNGR1) and Interferon gamma receptor 2 (IFNGR2). IFN-γ binding to the receptor activates...
56 KB (6,491 words) - 17:37, 16 July 2025
archetypal TNF-alpha. In their active form, the majority of TNF receptors form trimeric complexes in the plasma membrane. Accordingly, most TNF receptors contain...
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region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor". Proceedings of the National Academy...
25 KB (2,850 words) - 04:54, 15 July 2025
2014). "An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction". FEBS...
297 KB (32,094 words) - 22:01, 15 July 2025
viruses. However, they still have the Interferon-alpha/beta receptor, so they respond normally when recombinant interferon is added to their culture media....
7 KB (837 words) - 22:31, 29 May 2025
IFNAR1: encoding interferon alpha/beta receptor 1 IFNAR2: encoding interferon alpha/beta receptor 2 IFNGR2: encoding interferon gamma receptor 2 IL10RB: encoding...
33 KB (3,068 words) - 10:45, 6 June 2025
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear...
58 KB (6,134 words) - 01:39, 12 July 2025
Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin...
12 KB (1,508 words) - 17:56, 19 August 2022
Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon...
25 KB (2,751 words) - 21:50, 15 July 2025
interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature...
26 KB (3,273 words) - 08:48, 14 October 2024
process of seeded nucleation, alpha-synuclein adopts a cross-beta sheet structure characteristic of amyloid fibrils. The human alpha-synuclein protein consists...
84 KB (9,503 words) - 20:00, 16 July 2025
of nuclear import of the domain-specific androgen receptor in association with the importin alpha/beta and Ran-guanosine 5'-triphosphate systems". Endocrinology...
88 KB (9,476 words) - 16:58, 14 July 2025
Interferon alpha-n3 (Alferon-N) is a medication consisting of purified natural human interferon alpha proteins used for the treatment of genital warts...
3 KB (28 words) - 11:55, 15 September 2024
Interleukin-28 receptor is a type II cytokine receptor found largely in epithelial cells. It binds type 3 interferons, interleukin-28 A (Interferon lambda 1)...
10 KB (1,126 words) - 20:57, 24 June 2021
Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS)...
13 KB (1,292 words) - 19:17, 6 April 2024
Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and...
10 KB (787 words) - 09:47, 9 March 2025
Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear...
39 KB (4,526 words) - 06:00, 25 July 2024
alpha chain paired with the common beta (beta c or CD131) subunit. The gene for the alpha subunit is 40 kilobases long and has 12 exons. The receptor...
2 KB (206 words) - 15:30, 8 September 2024
cardiomyopathy showed almost doubled estrogen receptor alpha (ER-alpha) mRNA and protein levels, and the ER-alpha/beta-catenin interaction, present at intercalated...
102 KB (12,358 words) - 08:13, 14 July 2025