Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF...
6 KB (794 words) - 11:50, 18 May 2022
been identified in the juxtamembrane domain, the kinase insert, and in the C-terminal tail in the PDGFβ receptor. The phosphorylated tyrosine residue...
13 KB (1,563 words) - 09:00, 13 March 2024
insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically...
31 KB (3,785 words) - 05:54, 22 April 2024
tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have...
8 KB (755 words) - 18:51, 2 November 2023
including the mitogen activated protein (MAP) kinase pathway and the extracellular signal-related kinase (ERK) pathway. Activation of both of the MAP and...
157 KB (16,275 words) - 19:48, 22 May 2024
Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein...
32 KB (3,936 words) - 03:00, 29 January 2024
kinase-1 (flt-1) was shown to be a VEGF receptor by Ferrara et al. in 1992. The kinase insert domain receptor (KDR) was shown to be a VEGF receptor by...
40 KB (4,578 words) - 20:20, 10 March 2024
VEGFR-2 inhibitor (category Tyrosine kinase inhibitors)
VEGFR-2 inhibitor, also known as kinase insert domain receptor(KDR) inhibitor, are tyrosine kinase receptor inhibitors that reduce angiogenesis or lymphangiogenesis...
51 KB (4,735 words) - 08:15, 2 January 2024
endothelial growth factor receptor 2/kinase insert domain receptor (VEGFR2/KDR), and transmembrane protein 163 (TMEM163) receptors. Rubin H. (2008) Contact...
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fluorescence microscope. Annexin A5 has been shown to interact with Kinase insert domain receptor and Integrin, beta 5. GRCh38: Ensembl release 89: ENSG00000164111...
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college fraternity The ISO 639-3 code for the Karaim language Kinase insert domain receptor, a human protein Short distance radio or KDR 444, Norway and...
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Copenhagen. The GRIA2-encoded AMPA receptor ligand binding core (GluA2 LBD) was the first glutamate receptor ion channel domain to be crystallized. AMPARs are...
60 KB (7,019 words) - 07:40, 8 May 2024
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary...
58 KB (6,923 words) - 01:30, 3 May 2024
CD135 (redirect from Fms-related tyrosine kinase 3)
tyrosine-kinase insert. Cytoplasmic FLT3 undergoes glycosylation, which promotes localization of the receptor to the membrane. CD135 is a class III receptor tyrosine...
15 KB (1,728 words) - 08:50, 15 December 2023
receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is...
107 KB (12,051 words) - 23:49, 26 April 2024
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a...
46 KB (5,509 words) - 06:42, 23 May 2024
the kinase domain do not involve important domain-domain contacts away from the substrate binding site. Among a number of various molecules, Receptor Tyrosine...
19 KB (2,321 words) - 21:42, 5 January 2024
encoded by the SHC2 gene. SHC2 has been shown to interact with Kinase insert domain receptor. GRCh38: Ensembl release 89: ENSG00000129946 – Ensembl, May...
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by protein kinases, ultimately resulting in a cellular response. Proteins responsible for detecting stimuli are generally termed receptors, although in...
63 KB (7,624 words) - 03:29, 26 January 2024
KIT (gene) (redirect from Tyrosine kinase mutation)
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117)...
35 KB (4,118 words) - 18:22, 5 January 2024
Integrin (redirect from Integrin receptor)
transmembrane protein kinases such as receptor tyrosine kinases (RTK). While the interaction between integrin and receptor tyrosine kinases originally was thought...
36 KB (3,929 words) - 08:32, 12 May 2024
cytoplasmic domain has a juxtamembrane domain and tyrosine kinase domain that is interrupted by a kinase insert domain. At rest, the juxtamembrane domain of CSF1R...
44 KB (4,593 words) - 17:52, 18 April 2024
Proteases in angiogenesis (redirect from Receptor shedding)
endothelial associated proteins, such as VE-cadherin and kinase insert domain receptor (KDR, VEGF receptor 2) which aid in influencing the progression of angiogenesis...
50 KB (5,423 words) - 11:11, 28 March 2024
INTS12: Integrator complex subunit 12 KDR: Kinase insert domain receptor (Vascular endothelial growth factor receptor 2) KIAA1530: UV stimulated scaffold protein...
31 KB (1,913 words) - 03:37, 10 March 2024
activation of Src family kinases, which have been shown to play a role in regulating synaptic plasticity. VLDLR also acts as a receptor coupled to ApoER2 as...
27 KB (3,439 words) - 10:00, 27 March 2024
CAR T cell (redirect from Chimeric T cell receptor)
chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that...
75 KB (7,889 words) - 06:29, 20 May 2024
GRB2 (redirect from Growth factor receptor-bound protein 2)
growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each...
82 KB (9,365 words) - 15:39, 31 March 2024
repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor (Uniprot: P08581), Plexin-A3 (Uniprot: P51805)...
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PDGFRB (category Tyrosine kinase receptors)
The PDGFRB gene encodes a typical receptor tyrosine kinase, which belongs to the type III tyrosine kinase receptor (RTK) family and is structurally characterized...
31 KB (3,403 words) - 18:14, 24 December 2023
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2...
37 KB (4,300 words) - 06:32, 13 March 2024