• Thumbnail for Kinase insert domain receptor
    Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF...
    6 KB (794 words) - 11:50, 18 May 2022
  • Thumbnail for Insulin receptor
    insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically...
    32 KB (3,920 words) - 18:44, 1 May 2025
  • Thumbnail for VEGF receptor
    tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have...
    8 KB (758 words) - 08:47, 24 June 2025
  • Thumbnail for Endometriosis
    including the mitogen activated protein (MAP) kinase pathway and the extracellular signal-related kinase (ERK) pathway. Activation of both of the MAP and...
    164 KB (16,769 words) - 19:50, 18 June 2025
  • VEGFR-2 inhibitor (category Tyrosine kinase inhibitors)
    VEGFR-2 inhibitor, also known as kinase insert domain receptor(KDR) inhibitor, are tyrosine kinase receptor inhibitors that reduce angiogenesis or lymphangiogenesis...
    41 KB (4,751 words) - 17:22, 11 June 2025
  • Thumbnail for Platelet-derived growth factor receptor
    been identified in the juxtamembrane domain, the kinase insert, and in the C-terminal tail in the PDGFβ receptor. The phosphorylated tyrosine residue...
    13 KB (1,563 words) - 09:00, 13 March 2024
  • kinase-1 (flt-1) was shown to be a VEGF receptor by Ferrara et al. in 1992. The kinase insert domain receptor (KDR) was shown to be a VEGF receptor by...
    40 KB (4,578 words) - 12:30, 10 September 2024
  • Thumbnail for Tropomyosin receptor kinase C
    Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein...
    30 KB (3,901 words) - 00:12, 24 May 2025
  • endothelial growth factor receptor 2/kinase insert domain receptor (VEGFR2/KDR), and transmembrane protein 163 (TMEM163) receptors. Rubin H. (2008) Contact...
    2 KB (201 words) - 23:45, 12 October 2018
  • political party Karaim language, spoken in the Baltic (ISO 639:kdr) Kinase insert domain receptor, a human protein Kort Distanse Radio, in Scandinavia Kill-death...
    585 bytes (92 words) - 02:46, 6 December 2024
  • Thumbnail for KIT (gene)
    Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117)...
    35 KB (4,121 words) - 18:14, 23 May 2025
  • Thumbnail for AMPA receptor
    protein kinase A (PKA) which regulates its open probability. AMPA receptors are integral to fast excitatory neurotransmission in the CNS. Each receptor is...
    75 KB (8,581 words) - 15:07, 9 June 2025
  • Thumbnail for Hepatocyte growth factor receptor
    Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary...
    59 KB (6,731 words) - 05:32, 23 May 2025
  • A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses...
    46 KB (5,510 words) - 21:54, 29 November 2024
  • Thumbnail for Colony stimulating factor 1 receptor
    cytoplasmic domain has a juxtamembrane domain and tyrosine kinase domain that is interrupted by a kinase insert domain. At rest, the juxtamembrane domain of CSF1R...
    44 KB (4,600 words) - 20:25, 29 May 2025
  • Thumbnail for NMDA receptor
    receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is...
    109 KB (12,193 words) - 18:46, 20 June 2025
  • Thumbnail for CD135
    tyrosine-kinase insert. Cytoplasmic FLT3 undergoes glycosylation, which promotes localization of the receptor to the membrane. CD135 is a class III receptor tyrosine...
    15 KB (1,753 words) - 20:17, 29 May 2025
  • Thumbnail for Annexin A5
    fluorescence microscope. Annexin A5 has been shown to interact with Kinase insert domain receptor and Integrin, beta 5. GRCh38: Ensembl release 89: ENSG00000164111...
    13 KB (1,645 words) - 00:29, 11 March 2024
  • chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that...
    92 KB (9,308 words) - 20:16, 29 May 2025
  • Thumbnail for Low-density lipoprotein receptor-related protein 8
    activation of Src family kinases, which have been shown to play a role in regulating synaptic plasticity. VLDLR also acts as a receptor coupled to ApoER2 as...
    27 KB (3,439 words) - 10:00, 27 March 2024
  • Thumbnail for CD4
    CD4 (category Protein domains)
    recruit and interact with the tyrosine kinase Lck.[citation needed] CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating...
    22 KB (2,581 words) - 20:03, 21 June 2024
  • Thumbnail for Follicle-stimulating hormone receptor
    the phosphorylation of the intracellular (or cytoplasmic) receptor domain by protein kinases. This process uncouples Gs protein from the FSHR. Another...
    15 KB (1,730 words) - 06:34, 9 June 2025
  • Thumbnail for Chromosome 4
    Kinase insert domain receptor (Vascular endothelial growth factor receptor 2) KIAA1530: UV stimulated scaffold protein A KIT: tyrosine-protein kinase...
    31 KB (1,931 words) - 14:30, 20 April 2025
  • Thumbnail for Fruquintinib
    Fruquintinib (category Receptor tyrosine kinase inhibitors)
    medication used for the treatment of colorectal cancer. Fruquintinib is a kinase inhibitor. It is taken by mouth. The most common adverse reactions include...
    13 KB (834 words) - 20:45, 23 March 2025
  • Thumbnail for Hsp90
    to function as a kinase inhibitor but was subsequently shown to be an Hsp90 inhibitor where it uses a compact conformation to insert itself into the ATP...
    51 KB (5,551 words) - 00:49, 20 June 2025
  • and various isoforms of VEGF-A. Conbercept has a VEGF-R2 kinase insert domain receptor (KDR) Ig-like region 4 (KDRd4) which improves the three-dimensional...
    16 KB (1,699 words) - 06:32, 2 June 2025
  • the kinase domain do not involve important domain-domain contacts away from the substrate binding site. Among a number of various molecules, Receptor Tyrosine...
    19 KB (2,321 words) - 18:33, 17 May 2025
  • Thumbnail for PKC alpha
    Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific...
    20 KB (2,643 words) - 05:20, 30 November 2022
  • Thumbnail for Protein domain
    TIM-barrel in pyruvate kinase is 'discontinuous', meaning that more than one segment of the polypeptide is required to form the domain. This is likely to...
    71 KB (8,443 words) - 16:27, 25 May 2025
  • Thumbnail for PDGFRB
    PDGFRB (category Tyrosine kinase receptors)
    The PDGFRB gene encodes a typical receptor tyrosine kinase, which belongs to the type III tyrosine kinase receptor (RTK) family and is structurally characterized...
    31 KB (3,403 words) - 06:55, 9 June 2025