Lineage Cell Therapeutics, Inc. is a clinical-stage biotechnology company developing novel cell therapies for unmet medical needs. Lineage’s programs are...

expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate hematopoietic stem cells. In addition...

Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the greater its potency. Potency...

indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms...

universities like the Columbia Initiative in Cell Engineering and Therapy or biotech companies like Interius BioTherapeutics, Umoja Biopharma, or EsoBiotec. Porentially...

known as RG6501) is an investigational allogeneic cell therapy developed by Lineage Cell Therapeutics for the treatment of geographic atrophy (GA) secondary...

fields such as: Stem cell self-renewal Lineage specification Cancer cell phenotype Fibrosis Hepatocyte function Mechanosensing Cell culture in three dimensions...

suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells). MDSCs...

cells with a neural lineage. Induced somatic stem cells Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics"...

the patient's cells. In ex vivo gene therapies, such as CAR-T therapeutics, the patient's own cells (autologous) or healthy donor cells (allogeneic) are...

variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give...

P681R in lineage B.1.617. All three concerning mutations are on the spike protein, the operative part of the coronavirus that binds to receptor cells of the...

A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double...

develop and commercialize novel adult Mesenchymal Precursor Stem Cell (MPC) therapeutics for degenerative conditions of the cardiovascular and central nervous...

also any induced conformational changes. Small-molecule anti-genomic therapeutics, or SMAT, refers to a biodefense technology that targets DNA signatures...

receptor, and a partner for amino acid transporters". Pharmacology & Therapeutics. 128 (1): 119–28. doi:10.1016/j.pharmthera.2010.06.003. PMC 7112678....

85% of cases are of B-cell lineage and have an equal number of cases in both males and females. The remaining 15% of T-cell lineage have a male predominance...

e13. doi:10.1016/j.cell.2018.07.031. PMC 6128760. PMID 30122350. Opalinska JB, Gewirtz AM (July 2002). "Nucleic-acid therapeutics: basic principles and...

established stem cell lines. Muse cells (Multi-lineage differentiating stress enduring cell) are non-cancerous pluripotent stem cell found in adults....

Cardiovascular Program of the Harvard Stem Cell Institute, led to his co-founding, in 2010, of ModeRNA Therapeutics. In 2018, the company re-branded as Moderna...

on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with immunoglobulin. Startups including Juno Therapeutics exploit...

has been shown that the two cells develop from different hematopoietic lineages and thus cannot be the same cells. Mast cells are very similar to basophil...

Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics". International Journal of Cell Biology. 2016 (7): 6940283...

Treg lineage stability. The biotech company TG Therapeutics is working on anti-GITR antibodies ICOS: This molecule, short for Inducible T-cell costimulator...

between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics ... The...

developmental stage, cells (blastomeres) were not specified to any particular cell lineage but, when reaching the 16-cell stage, cells at the surface of...

Jennifer; Mortha, Arthur (2013). "The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed...

from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal...

of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs. iPSCs are...

sphingomyelin within lysosomes in the macrophage-monocyte phagocyte lineage. Affected cells become enlarged, sometimes up to 90 μm in diameter, secondary to...