mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and...

protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation...

proliferation by forming and signaling through two protein complexes, mTORC1 and mTORC2. The most established mTOR inhibitors are so-called rapalogs (rapamycin...

mTORC2) is not inhibited by rapamycin and regulates a different signaling pathway from mTORC1. Hall also identified many roles of mTORC1 and mTORC2,...

rapamycin complex 2 (mTORC2 at serine 473 (Akt1) and 474 (Akt2)) which is found at high levels in the fed state, first by mTORC2. mTORC2 therefore functionally...

internalized immune complexes rises from irregularly extended activity of mTORC2, which impairs lysosome acidification. As a result, immune complexes in...

more selective for the mTORC1 protein complex, with little impact on the mTORC2 complex. This can lead to a hyper-activation of the kinase AKT via inhibition...

autophagy, reduced mTORC1 activity, and increased mTORC2 activity. DDIT4/ REDD1 mTOR mTORC1 mTORC2 GRCh38: Ensembl release 89: ENSG00000145358 – Ensembl...

inhibition of mTORC1 appears to mediate the drug's benefits, it also inhibits mTORC2, which results in diabetes-like symptoms. This includes decreased glucose...

or mTOR complex 2 (mTORC2). RICTOR is a key component of mTORC2, which, unlike mTORC1, is not directly inhibited by rapamycin. mTORC2, and RICTOR, specifically...

Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2". International Journal of Molecular Sciences. 23 (15): 8798. doi:10.3390/ijms23158798...

which is found in 2 complexes in cells: mTOR complex 1 and 2 (mTORC1 and mTORC2). mTORC1 is activated through the T cell receptor (TCR) and the costimulatory...

protein kinase B (AKT), and mechanistic target of rapamycin complex 2 (mTORC2). As a result of downregulated signaling through these proteins, opiates...

rapamycin-insensitive mTORC2. MTORC1 consists of five proteins including Raptor that positively regulate mTOR activity. MTORC2 consists of six proteins...

pathway, mTORC1 and mTORC2 which both regulate protein synthesis required for cell growth, angiogenesis, and proliferation. mTORC2 stimulates AKT activity...

inhibitors of the mechanistic target of rapamycin (mTOR) subtypes mTORC1 and mTORC2. In animal studies it has anti-inflammatory, anti-cancer, and anti-aging...

diseases such as cancer. For example, his lab discovered the mTORC1 and mTORC2 multi-protein complexes, the nutrient sensing Rag GTPase pathway upstream...

integrin-linked kinase (ILK), mechanistic target of rapamycin complex complex 2 (mTORC2) and DNA-dependent protein kinase (DNA-PK). The regulation of Ser473 phosphorylation...

FRB regulatory region inhibits mTORC1 through processes not yet known. mTORC2 is also inhibited by rapamycin in some cell culture lines and tissues, particularly...

rapamycin-insensitive companion of mTOR (rictor), the complex is known as mTORC2 and it is insensitive to rapamycin. However, the complex mTORC1 formed by...

inhibitor of mTOR which is administered orally. It targets both mTORC1 and mTORC2. Developed by Millennium Pharmaceuticals, and is in phase II clinical trials...

associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient...

phosphoinositide-dependent protein kinase PDPK1 and mammalian target of rapamycin mTORC2. It has been shown to "regulate several enzymes and transcription factors;...

distinct protein assemblies: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTOR signaling serves as a central regulator of cell metabolism, growth...

hydrophobic motif, is phosphorylated in an mTORC2-dependent manner, leading some investigators to hypothesize that mTORC2 is the long-sought PDK2 molecule. Threonine308...

Research Prize by the Hans- and Ilse Breuer Foundation Scientific career Fields Diseases, Drug Discovery, mTORC2, Autophagy Website https://celegans.de/...

other subtype mTORC2, it is hoped that selective inhibition of mTORC1 should have a more selective effects profile. As mTORC1 and mTORC2 have binding sites...

(February 2019). "The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2". Molecular Cell. 73 (4): 830–844.e12. doi:10.1016/j.molcel.2018.12.001...

Claiborne TM, Rajfur Z, Jacobson K, Moorman NJ, Vilen BJ (July 2018). "mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus...

both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for potential applications in the treatment of various...