• Mitotic exit is an important transition point that signifies the end of mitosis and the onset of new G1 phase for a cell, and the cell needs to rely on...
    27 KB (3,412 words) - 05:38, 24 March 2025
  • Thumbnail for Mitosis
    Mitosis (redirect from Mitotic)
    Yen TJ (2003). "The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit". Progress in Cell Cycle...
    70 KB (7,272 words) - 16:07, 13 July 2025
  • Thumbnail for Telophase
    seen in budding yeast, which do not have redundant phosphatases for mitotic exit and rely on the phosphatase cdc14. Blocking cdc14 activation in these...
    23 KB (2,682 words) - 22:30, 15 July 2025
  • representation of mitotic entry, but not necessarily mitotic exit. It is necessary to inactivate the cyclin B-Cdk1 complex in order to exit the mitotic stage of...
    50 KB (6,678 words) - 21:54, 13 July 2024
  • Thumbnail for Anaphase-promoting complex
    targets the mitotic cyclins for degradation, resulting in the inactivation of M-CDK (mitotic cyclin-dependent kinase) complexes, promoting exit from mitosis...
    31 KB (4,194 words) - 08:16, 24 June 2025
  • Thumbnail for Hysteresis
    for exiting mitosis was lower, between 16 and 24 nM cyclin B. The higher threshold for mitotic entry compared to the lower threshold for mitotic exit indicates...
    73 KB (9,125 words) - 21:47, 19 June 2025
  • regulatory serine/threonine kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. Only one Plk is...
    10 KB (1,510 words) - 05:50, 27 May 2025
  • Thumbnail for SUMO protein
    the case of Tof2-Cdc14, Cdc14 release from the nucleolus allows the Mitotic Exit Network to commence, but it is regulated by the binding of Tof2, a protein...
    40 KB (4,911 words) - 05:00, 15 July 2025
  • Thumbnail for Mitotic catastrophe
    likelihood to undergo mitotic catastrophe. For instance, cells can undergo a process called mitotic slippage where cells exit mitosis too early before...
    30 KB (3,020 words) - 18:33, 23 May 2025
  • Early Mitotic Inhibitor 1 (EMI1) is an important cell cycle regulator which ensures timely mitotic entry by primarily inhibiting Anaphase-Promoting Complex/Cyclosome...
    18 KB (2,170 words) - 04:49, 2 June 2025
  • understood and most-studied, the activity of Cdc14 (ScCdc14) leads to mitotic exit by dephosphorylating targets of Cdk1, a well-studied cyclin-dependent...
    24 KB (2,752 words) - 23:54, 25 August 2023
  • Thumbnail for Sirtuin 2
    "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Molecular and Cellular Biology. 23 (9): 3173–3185...
    29 KB (3,221 words) - 18:15, 28 May 2025
  • including the G2/M transition, the metaphase/anaphase transition, and mitotic exit. Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization...
    16 KB (2,132 words) - 04:47, 22 June 2025
  • Thumbnail for P21
    Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit". Cell. 155 (2): 369–383. doi:10.1016/j.cell.2013.08.062. PMC 4001917...
    34 KB (3,931 words) - 20:49, 22 May 2025
  • Thumbnail for Sirtuin
    "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Molecular and Cellular Biology. 23 (9): 3173–85....
    28 KB (2,326 words) - 11:56, 17 January 2025
  • protein Net1 in late anaphase, which is triggered by the action of the mitotic exit network (MEN). In later work, they established that an early step in...
    19 KB (2,519 words) - 13:21, 23 June 2025
  • Thumbnail for Cadherin-1
    Alvarez-Fernandez M, Stahl M, Medema RH (September 2008). "FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner". Cell Cycle. 7 (17): 2720–6. doi:10.4161/cc...
    54 KB (6,385 words) - 08:08, 15 July 2025
  • Thumbnail for TPX2
    in TPX2 at mitotic exit is dependent on both the anaphase-promoting complex/cyclosome (APC/C) and an ubiquitin ligase integral in mitotic progression...
    38 KB (4,947 words) - 04:52, 15 July 2025
  • Thumbnail for Oklahoma Medical Research Foundation
    in women. In 2006, OMRF researchers demonstrated the reversibility of mitotic exit (cell division) in vertebrate cells. In the 1980s, OMRF researchers studied...
    17 KB (1,693 words) - 00:31, 9 July 2025
  • Thumbnail for Rong Li
    subsequently made a number of significant discoveries in the area of mitotic exit control and cytokinesis. She is recognized as a leader in the study of...
    25 KB (2,616 words) - 22:39, 26 May 2025
  • Thumbnail for BUB3
    and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation. Bub3 is a crucial component in the formation of the mitotic spindle...
    18 KB (2,197 words) - 21:27, 15 July 2025
  • Thumbnail for Chitinase
    different phases of the cell, such as Cdc14 Early Anaphase Release (FEAR), mitotic exit network (MEN), and regulation of Ace2p (transcription factor) and cellular...
    29 KB (3,212 words) - 13:16, 1 July 2025
  • dielectrophoresis of critical molecules and organelles during mitosis. These anti-mitotic effects lead to cell death, slowing cancer growth. A TTField-treatment...
    24 KB (2,471 words) - 06:40, 28 June 2025
  • Thumbnail for FOXM1
    Alvarez-Fernandez M, Stahl M, Medema RH (September 2008). "FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner". Cell Cycle. 7 (17): 2720–6. doi:10.4161/cc...
    13 KB (1,506 words) - 17:03, 23 February 2025
  • Thumbnail for Cell cycle checkpoint
    into mitosis. The mitotic spindle checkpoint occurs at the point in metaphase where all the chromosomes should/have aligned at the mitotic plate and be under...
    34 KB (4,587 words) - 15:21, 9 December 2024
  • Thumbnail for Frank Uhlmann
    cycle have shown that as well as cleaving cohesin, separase promotes mitotic exit by activating the Cdc14 phosphatase in a protease-independent manner...
    11 KB (836 words) - 08:48, 25 December 2024
  • Thumbnail for Cyclin-dependent kinase 1
    cyclins leads to the final events of mitosis (e.g., spindle disassembly, mitotic exit). Given its essential role in cell cycle progression, Cdk1 is highly...
    25 KB (2,896 words) - 12:38, 29 August 2024
  • Thumbnail for Aurora kinase A
    the mitotic poles and the adjacent spindle microtubules. Aurora A remains associated with the spindles through telophase. Right before mitotic exit, Aurora...
    22 KB (2,712 words) - 11:07, 20 April 2025
  • through the ubiquitin pathway. Degradation of cyclin A/CDK1 induces mitotic exit. Cyclin A/CDK2 complex was thought to be restricted to the nucleus and...
    14 KB (1,753 words) - 03:43, 26 August 2024
  • Thumbnail for PRC1
    dramatically after mitotic exit and entrance into G1 phase. PRC1 is located in the nucleus during interphase, becomes associated with the mitotic spindle in a...
    14 KB (1,806 words) - 22:11, 15 July 2025