Mutational signatures are characteristic combinations of mutation types arising from specific mutagenesis processes such as DNA replication infidelity...

TMB is defined as the number of somatic mutations/megabase whereas mutational signatures are distinct mutational patterns of single base substitutions,...

relevant mutational signatures associated with BRCA1/BRCA2 deficiency, irrespective of whether these signatures are the dominant mutational process in...

previously demonstrated to have a characteristic mutational signature. The same mutational signature was discovered in several cohorts of colon cancer...

Cambridge in 2014. Alexandrov is known for developing the concept of mutational signatures together with Michael Stratton and colleagues at the Wellcome Sanger...

although not all necessarily are. All mutagens have characteristic mutational signatures with some chemicals becoming mutagenic through cellular processes...

DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This polymerase plays a key role in one of the three major double strand...

context-dependent mutations can be represented in the form of a nonnegative matrix. This matrix can be further decomposed into components (mutational signatures) which...

signature of phylogenetically related genomes is similar. Gene signature mutational signatures Alignment-free sequence analysis Bioinformatics Computational...

Steven G.; Tan, Patrick; Teh, Bin Tean (7 August 2013). "Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool". Science...

DNA rearrangements. COSMIC also catalogues mutational signatures in human cancer through the COSMIC Signatures group, which represents a collaboration between...

frequency, distribution and mutation patterns of cancer. She showed that it was possible to identify mutational signatures using downstream analysis, and...

subjects for optimal benefit of specific treatments. Genomic signature Mutational signatures Gene expression profiling Gene expression profiling in cancer...

Guan, P.; Weng, W.-H.; Siew, E. Y.; Liu, Y. (2013). "Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool". Science...

genetic drift. For example, smaller populations with heavy mutational input (high rates of mutation) are prone to increases of genetic variation which lead...

Fleischmann Z, Tse JY, Decker B (March 2022). "Prevalence of UV Mutational Signatures Among Cutaneous Primary Tumors". JAMA Network Open. 5 (3): e223833...

have distinctive mutational signatures that reflect differences in the contributions of mutational pathways. Mutational signatures have proved useful...

cancer to develop in an individual can be identified by analyzing mutational signatures from genomic sequencing of tumor DNA. For example, this can reveal...

cancer-specific research but are not reflected in economics and policy. Mutational signatures of various cancers, for example, could reveal further causes of...

plasma tend to occur on longer cfDNA fragments, and to lack specific mutational signatures such as those associated with tobacco smoking in lung cancer that...

the prevalence of breast cancer biomarkers and metabolite signatures indicated unique signatures that are currently undergoing further validation in larger...

Tse, Julie Y.; Decker, Brennan (23 March 2022). "Prevalence of UV Mutational Signatures Among Cutaneous Primary Tumors". JAMA Network Open. 5 (3): e223833...

manifested in different context-dependent mutational profiles. It can be explored by COSMIC mutational signatures or MutaGene. Tumour cells can also show...

Steele, E.J. (2013). "Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of...

Scott Lawrence is an American geneticist best known for his work on mutational signatures. Lawrence is an assistant professor of pathology at the Harvard...

MCV-induced MCC, these tumors tend to have much higher mutational burdens with mutational signatures characteristic of UV damage. Genes frequently mutated...

and cancer: Critical analysis of strand-biased and codon-context mutation signatures". DNA Repair. 45 (2016): 1–2 4. doi:10.1016/j.dnarep.2016.07.001...

cross-link where it was shown on the basis of the difference in the mutational signatures of the two polymerases, that pol IV and pol V compete for TLS of...

See-Tong; Tan, Patrick; Teh, Bin Tean; Rozen, Steven G. (Dec 2015). "Mutation signatures implicate aristolochic acid in bladder cancer development". Genome...

Mutationism is one of several alternatives to evolution by natural selection that have existed both before and after the publication of Charles Darwin's...