B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival. NF-κB...

lymphocytes. The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates...

degradation of I-κB. I-κB blocks the NLS of NF-κB therefore preventing its translocation to the nucleus. Once I-κB is degraded, it cannot bind to NF-κB and the...

derivatives are synthesized by regio/stereoselective Michael addition to ring A. NF-κB is a transcription factor that regulates many genes involved in cell survival...

addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning. The gene encoding...

by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has...

IκBα, and this inhibits NF-κB translocation to the nucleus. Pevonedistat, through its effects on NF-κB and a target of NF-κB (microRNA-155), prolonged...

H1-antihistamines can also reduce inflammation, since the expression of NF-κB, the transcription factor the regulates inflammatory processes, is promoted...

activation of the canonical NF-κB pathway by TNFR1. Thus, TNFR2 non-canonical NF-κB activation is dependent on the canonical NF-κB activation by TNFR1, as...

a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation. NF-κB is an essential transcription factor complex...

inhibit NF-κB activation and cell proliferation. An experiment of Hu et al. (2002) demonstrated increased binding activity of AP-1 and NF-κB after acute...

later were shown to be key mediators of NF-κB signaling and necroptosis, respectively. Incorrect regulation of NF-κB has been linked to cancer, inflammatory...

(CRMO or Behçet disease) IL-1 mediated IFN-mediated Mediated by increased NF-κB activation Most proteins known to be involved in hereditary AIDs are involved...

and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor that is activated by various...

is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. The human gene for IKBKG is located on the chromosome band...

for his pioneering research on the activation of cellular responses via NF-κB, a transcription factor that plays a critical role in regulating the expression...

synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages". Science Signaling. 9 (457): ra120...

protein that cleaves A20, an inhibitory protein of NF-κB signaling (which acts by deubiquitylating NF-κB's ubiquitylation substrates, having an inhibitory...

inhibitor of NF-κB, allowing NF-κB to be activating. When MC160 binds heat shock protein 90, IKK is degraded and the inhibitor remains bound to NF-κB, thus making...

regulator of NF-κB activation by recruitment and activation of MALT1. When overexpressed in cells, this protein family activates NF-κB and induces the...

exhibit pathologically overactive NF-κB, PI3K/AKT/mTOR, JAK-STAT0, MAPK/ERK, B-cell receptor, toll-like receptor, and NF-κB signaling pathways and thereby...

survival. Akt also activates IKKα, which leads to NF-κB activation and cell survival. Active NF-κB induces the expression of anti-apoptotic genes such...

effect on NF-κB also induces apoptosis of alveolar macrophage. Prolonged exposure to CSE hence leads to M2 polarization. Meanwhile, NF-κB pathways will...

phosphorylation in mitochondria, and the modulation of signaling through NF-κB, are also being investigated. Some of its effects are like those of salicylic...

autophagosomes that digest defective mitochondria. Through activation of NF-κB signalling, parkin enhances survival and protects cells from stress-induced...

through NF-κB, a protein complex which acts as a transcription factor. In the rat, an NF-κB binding site is adjacent to the mdr1b gene, NF-κB can be active...

crucial protein for T and B lymphocytes activation. It has an important role in the activation of the transcription factor NF-κB, in the production of interleukin-2...

to induce apoptosis, and also activates non-apoptotic pathways such as NF-κB and MAPK. FasL exists in membrane-bound and soluble forms, and is primarily...

ligands in structure-based virtual screening studies. The expression of NF-κB, the transcription factor that regulates inflammatory processes, is promoted...

in the inhibition of B cell proliferation. It is also known to induce NF-κB inhibitor IKBa, inhibiting NF-κB activation. NF-κB is a transcription factor...