Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract's epithelial cells as well as in hepatocytes. Specifically, it appears...
6 KB (691 words) - 03:50, 9 February 2025
reported and are included as warnings on the label for ezetimibe. Since NPC1L1 also regulates vitamin K uptake, the use of ezetimibe can lead to side effects...
20 KB (1,845 words) - 14:47, 31 March 2025
K2 from foods. The intestinal membrane protein Niemann–Pick C1-like 1 (NPC1L1) mediates cholesterol absorption. Animal studies show that it also factors...
69 KB (7,737 words) - 09:54, 9 June 2025
by decreasing the absorption of cholesterol in the GI tract by targeting NPC1L1, a transport protein in the gastrointestinal wall. This results in decreased...
47 KB (4,488 words) - 02:33, 25 May 2025
Ezetimibe/rosuvastatin combines two lipid-lowering therapies. Ezetimibe inhibits NPC1L1, the transporter that is responsible for absorption of dietary cholesterol...
8 KB (384 words) - 16:11, 24 February 2025
SCH-48461 is a cholesterol absorption inhibitor. During the early phases of an NPC1L1 inhibitor discovery program at Schering-Plough, conformationally restricted...
4 KB (251 words) - 22:43, 27 May 2025
PPARdelta activation coincides with decreased intestinal expression of NPC1L1". Journal of Lipid Research. 46 (3): 526–534. doi:10.1194/jlr.M400400-JLR200...
18 KB (1,963 words) - 03:11, 2 June 2025
plant sterols over cholesterol. Dietary sterols enter intestinal cells via NPC1L1, which prefers cholesterol over plant sterols. About 50%–60% of cholesterol...
11 KB (1,200 words) - 00:58, 15 June 2025
P48145 10714 NPBWR2 HGNC:4530 P48146 10715 NPC1 HGNC:7897 O15118 10716 NPC1L1 HGNC:7898 Q9UHC9 10717 NPC2 HGNC:14537 P61916 10718 NPDC1 HGNC:7899 Q9NQX5...
282 KB (17 words) - 09:28, 10 February 2025
PMID 24752831. Liao J, Yang L, Zhou L, Zhao H, Qi X, Cui Y, Ouyang D (2022). "The NPC1L1 Gene Exerts a Notable Impact on the Reduction of Low-Density Lipoprotein...
5 KB (223 words) - 17:29, 23 October 2024
exchangers (TMEM165(SLC64A1)) NPC-type cholesterol transporters (NPC1(SLC65A1), NPC1L1(SLC65A2)) Cationic amino acid exporters (SLC66A1, SLC66A2, SLC66A3, CTNS(SLC66A4)...
35 KB (3,407 words) - 13:57, 6 June 2025
Einarsson C, Eriksson M, Han TQ, Parini P, Eggertsen G (Jan 2009). "Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients"...
8 KB (1,056 words) - 13:29, 18 January 2024
hypertension. Thornberry also helped to identify Niemann-Pick C1-Like 1 (NPC1L1) as the target of ezetimibe, an inhibitor of cholesterol absorption. In...
19 KB (1,720 words) - 14:48, 16 February 2025
involved in intracellular cholesterol transport. Niemann-Pick type C1-like 1 (NPC1L1), a regulator of cholesterol absorption in enterocytes. Patched (PTCH1,...
3 KB (370 words) - 20:29, 11 September 2020
intestinal absorption of cholesterol by binding to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal epithelium. This reduces the delivery of...
47 KB (5,038 words) - 16:55, 22 May 2025