encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies. The PDGFRB gene is located...
31 KB (3,407 words) - 06:53, 15 July 2025
Kosaki overgrowth syndrome is a rare syndrome caused by mutations in the PDGFRB gene. The features of this syndrome affect the face, skin, brain and the...
3 KB (306 words) - 10:06, 13 May 2025
>1 billion/L, no Philadelphia chromosome or mutations in the PDGFRA or PDGFRB gene should be present, the blast count must be <20% and dysplasia of at...
25 KB (2,938 words) - 08:12, 12 June 2025
Infantile myofibromatosis (section PDGFRB gene)
mutations in either the PDGFRB or NOTCH3 gene. However, most IMF cases have no family history of the disease but nonetheless have PDGFRB gene mutations in their...
31 KB (3,748 words) - 04:29, 2 June 2025
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the...
50 KB (5,522 words) - 18:03, 29 July 2025
lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, FGFR1, and, tentatively, PCMA-JAK2. Informally, these diseases are also...
48 KB (5,760 words) - 06:38, 5 June 2025
rearrangements in PDGFRA, PDGFRB, or FGFR1. CEL not otherwise specified (CEL NOS) is a form in which BCR-ABL1 fusion genes and PDGFRA, PDGFRB, and FGFR1 rearrangements...
4 KB (332 words) - 04:18, 14 June 2024
Myeloid/lymphoid neoplasms with PDGFRA rearrangement Myeloid/lymphoid neoplasms with PDGFRB rearrangement Myeloid/lymphoid neoplasms with FGFR1 rearrangement Myeloid/lymphoid...
24 KB (2,344 words) - 12:25, 30 May 2025
this condition: PDGFB on chromosome 22 and PDGFRB on chromosome 5. These genes are biochemically linked: PDGFRB encodes the platelet-derived growth factor...
22 KB (2,492 words) - 18:00, 17 July 2025
released from endothelial cells in brain vasculature and binds to the receptor PDGFRB on pericytes, initiating their proliferation and investment in the vasculature...
40 KB (4,676 words) - 15:48, 23 May 2025
mab human hepatocyte growth factor (HGF) solid tumors Rinucumab mab human PDGFRB neovascular age-related macular degeneration Risankizumab Skyrizi mab humanized...
146 KB (4,507 words) - 04:33, 1 August 2025
(2015). "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. 144 (3): 377–92. doi:10...
16 KB (1,918 words) - 07:56, 25 May 2025
MATK; MERTK; MET; MLTK; MST1R; MUSK; NPR1; NTRK1; NTRK2; NTRK3; PDGFRA; PDGFRB; PKDCC; PLK4; PTK2; PTK2B; PTK6; PTK7; RET; ROR1; ROR2; ROS1; RYK; SRC;...
44 KB (5,283 words) - 00:21, 21 July 2025
receptor tyrosine kinase is a negative prognostic factor. Expression of PDGFRB is a positive prognostic factor. In general, mesothelioma is characterized...
95 KB (10,699 words) - 06:30, 19 July 2025
family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...
26 KB (2,837 words) - 05:16, 19 July 2025
chromosomal translocation in which the COL1A1 gene becomes fused to the PDGFRB gene. This results in over-active PDGF signaling, which is thought to promote...
37 KB (4,140 words) - 09:09, 9 June 2025
2015). "Hematolymphoid neoplasms associated with rearrangements of PDGFRA, PDGFRB, and FGFR1". American Journal of Clinical Pathology. 144 (3): 377–92. doi:10...
8 KB (840 words) - 12:50, 11 July 2025
been discovered: Cancer cells begin to overexpress cell surface protein PDGFRB, creating an alternative survival pathway. A second oncogene called NRAS...
21 KB (1,795 words) - 22:31, 29 May 2025
Nilotinib inhibits the kinases BCR-ABL, KIT, LCK, EPHA3, EPHA8, DDR1, DDR2, PDGFRB, MAPK11 and ZAK. Structurally related to imatinib, it is 10–30 fold more...
24 KB (1,908 words) - 21:40, 29 May 2025
molecule 2013 Non-small cell lung cancer Axitinib VEGFR1/VEGFR2/VEGFR3/PDGFRB/c-KIT Pfizer Small molecule 2012 Renal cell carcinoma Bosutinib Bcr-Abl...
24 KB (829 words) - 03:48, 22 June 2025
with the two tyrosine kinase receptor monomers, PDGFRα (PDGFRA) and -Rβ (PDGFRB). The PDGF family also includes a few other members of the family, including...
24 KB (2,882 words) - 15:04, 24 May 2025
syndrome 9q34 D Kniest dysplasia COL2A1 1:1,000,000 Kosaki overgrowth syndrome PDGFRB Krabbe disease GALC 1:100,000 Kufor–Rakeb syndrome ATP13A2 LCAT deficiency...
43 KB (995 words) - 17:13, 17 July 2025
family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...
9 KB (976 words) - 07:15, 24 June 2025
family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...
17 KB (1,844 words) - 17:19, 16 July 2025
family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...
18 KB (2,085 words) - 18:53, 16 July 2025
family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...
19 KB (2,341 words) - 14:41, 23 May 2025
AKT1, PIK3CA, MAGI1, SYNE1, USP9X, KLNI (also termed CASC5), RNF213, FLCN, PDGFRB, AR (i.e. the androgen receptor gene), BTK, MLL3, KAT6A, BRD3, EP400, TET2...
22 KB (2,440 words) - 21:14, 6 January 2024
This disorder is known to be caused by mutations in germline variants, PDGFRB and NOTCH3, which may be generationally-inherited through autosomal dominant...
22 KB (2,724 words) - 04:06, 20 May 2024
family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB) FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1...
60 KB (6,879 words) - 01:06, 1 March 2025
Pasquali F, Panarello C (Apr 2004). "HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)". Cancer Res...
3 KB (423 words) - 04:47, 15 July 2025