Peripherally selective drugs have their primary mechanism of action outside of the central nervous system (CNS), usually because they are excluded from...

medication. Trospium chloride is a peripherally selective non-selective muscarinic antagonist to quell peripheral muscarinic agonist-dependent side effects...

highly selective serotonin 5-HT3 receptor antagonist, with low affinity for dopamine receptors. The 5-HT3 receptors are present both peripherally on vagal...

ergotamine/caffeine. The drug is a non-selective modulator or agonist of serotonin receptors and other receptors. It is peripherally selective and crosses into...

Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor". Drug Metabolism and Disposition. 43 (9): 1294–1302. doi:10.1124/dmd...

blood–brain barrier under normal circumstances and hence is a peripherally selective drug. Norepinephrine, or noradrenaline, also known as 3,4,β-trihydroxyphenethylamine...

an antiobesity drug candidate which acts as a peripherally-restricted cannabinoid inverse agonist at CB1 receptors. It is very selective for the CB1 subtype...

nervous system Peripherally selective drug, a drug with a primary mechanism of action outside of the central nervous system Peripheral nervous system...

that of psychedelic drugs like psilocin. Unlike these drugs however, AL-34662 was designed specifically as a peripherally selective drug, which does not cross...

example is peripherally-selective drugs, which do not cross the blood-brain-barrier into the central nervous system and hence are tissue-selective for the...

14.5 h and plasma protein binding of 84–90%. Bilastine is a peripherally selective drug, and this is thought to be due to limited brain uptake caused...

weaning is provided in the drug information for cetirizine.[unreliable medical source?] Cetirizine acts as a highly selective antagonist of the histamine...

cytochrome P450-related drug interactions, for instance with inhibitors and inducers of these enzymes. Accordingly, the broad/non-selective cytochrome P450 inhibitor...

or preventing gout inflammation. Colchicine appears to be a peripherally selective drug with limited brain uptake due to binding to P-glycoprotein. The...

allergic rhinitis and urticaria. Therapeutically, fexofenadine is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine...

anastrozole may have peripheral selectivity in humans, although this has yet to be confirmed. In any case, estradiol is synthesized peripherally and readily crosses...

Phenylephrine does not cross the blood–brain barrier and hence is a peripherally selective drug with no central nervous system activity. Its lack of blood-brain...

brain permeability, whereas phenylephrine and norepinephrine are peripherally selective drugs. The optimal log P for brain permeation and central activity...

ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as...

no reported cases of clinically evident drug-induced liver injury associated with bisoprolol. Non-selective beta-blockers should be avoided in people...

AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. Other...

Loratadine is a tricyclic antihistamine, which acts as a selective inverse agonist of peripheral histamine H1 receptors. The potency of second generation...

3-202) Neluxicapone Nitecapone (OR-462) Entacapone and opicapone are peripherally selective inhibitors, unable to cross the blood–brain barrier (BBB), and hence...

AZD-1940 is a drug developed by AstraZeneca, that is a peripherally selective cannabinoid agonist which binds with high affinity to both the CB1 and CB2...

Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid receptor antagonist. With the limited ability to cross the blood–brain...

JO 1196 for the (-) tartrate salt) is an opioid drug which acts as a peripherally specific selective κ1-opioid receptor agonist with preference for the...

AZ-11713908 is a drug developed by AstraZeneca which is a peripherally selective cannabinoid agonist, acting as a potent agonist at the CB1 receptor and...

brain permeability, whereas phenylephrine and norepinephrine are peripherally selective drugs. The optimal log P for brain permeation and central activity...

Nufenoxole (SC-27166) is an antidiarrhoeal drug which acts as a peripherally selective opioid agonist, in a similar manner to loperamide. while it is...

significantly cross the blood–brain barrier. As a result, it is a peripherally selective drug and does not act in the brain. Entacapone is primarily metabolized...