• Plasma protein binding refers to the degree to which medications attach to blood proteins within the blood plasma. A drug's efficacy may be affected by...
    8 KB (1,083 words) - 13:38, 25 May 2025
  • that exhibit substantial plasma protein binding, clearance is generally dependent on the total concentration (free + protein-bound) and not the free concentration...
    15 KB (1,925 words) - 14:35, 4 June 2025
  • Thumbnail for Sex hormone-binding globulin
    cells in the seminiferous tubules of the testis, it is called androgen-binding protein (ABP). Other steroid hormones such as progesterone, cortisol, and other...
    57 KB (4,574 words) - 00:37, 18 December 2024
  • in the tissues. The binding between a drug and plasma protein is rarely specific and is usually labile and reversible. The binding generally involves ionic...
    9 KB (1,433 words) - 01:53, 29 August 2023
  • plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein...
    9 KB (1,132 words) - 01:43, 6 November 2024
  • known as pregnancy-associated plasma protein A, and insulin-like growth factor binding protein-4 protease is a protein encoded by the PAPPA gene in humans...
    5 KB (562 words) - 10:00, 27 March 2024
  • Thumbnail for Retinol binding protein 4
    Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately...
    16 KB (2,039 words) - 05:39, 12 May 2025
  • Thumbnail for Cetirizine
    plasma protein binding of cetirizine has been found to be 93 to 96% across a range of 25 to 1,000 ng/mL independent of concentration. Plasma protein binding...
    39 KB (3,455 words) - 02:16, 22 May 2025
  • Thumbnail for Retinol-binding protein
    Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol. Assessment of retinol-binding protein...
    13 KB (1,604 words) - 06:38, 2 June 2025
  • diseases. It is typically associated with high-T3 syndrome, increased plasma protein binding of thyroid hormones, and an elevated set point of the homeostatic...
    31 KB (3,385 words) - 01:03, 28 April 2025
  • Thumbnail for Sertraline
    Sertraline is highly plasma protein bound (98.5%) across a concentration range of 20 to 500 ng/mL. Despite the high plasma protein binding, sertraline and...
    106 KB (10,805 words) - 11:35, 4 June 2025
  • Thumbnail for Clonazepam
    vary as much as tenfold between different patients. Clonazepam has plasma protein binding of 85%. Clonazepam passes through the blood–brain barrier easily...
    78 KB (7,591 words) - 23:58, 29 May 2025
  • Thumbnail for Lipopolysaccharide binding protein
    Lipopolysaccharide binding protein (LBP) is a protein that in humans is encoded by the LBP gene. LBP is a soluble acute-phase protein that binds to bacterial...
    12 KB (1,454 words) - 17:56, 21 December 2023
  • Thumbnail for Metformin
    molecular weight and lack of plasma protein binding, these techniques have the benefit of removing metformin from the blood plasma, preventing further lactate...
    158 KB (15,083 words) - 23:45, 2 June 2025
  • ligand binding assay techniques were used extensively to quantify hormone or hormone receptor concentrations in plasma or in tissue. The ligand-binding assay...
    33 KB (4,118 words) - 11:15, 25 May 2025
  • indicator of thyroid status in the presence of abnormalities in plasma protein binding. This test is rarely used now that reliable free thyroxine and free...
    40 KB (3,677 words) - 16:50, 6 November 2024
  • Thumbnail for Protein S
    plasma steroid hormone-binding proteins such as sex hormone-binding globulin and corticosteroid-binding globulin. It may play a role in the protein functions...
    16 KB (2,008 words) - 05:48, 8 March 2025
  • occasionally, also low TSH concentrations, low-T4 syndrome and impaired plasma protein binding of thyroid hormones. This endocrine pattern is referred to as euthyroid...
    29 KB (2,926 words) - 16:46, 30 March 2025
  • Thumbnail for Testosterone
    females. The plasma protein binding of testosterone is 98.0 to 98.5%, with 1.5 to 2.0% free or unbound. It is bound 65% to sex hormone-binding globulin (SHBG)...
    150 KB (15,796 words) - 18:42, 23 May 2025
  • Thumbnail for Pseudoephedrine
    these substances also cross the placenta and enter breast milk. The plasma protein binding of pseudoephedrine has been reported to be approximately 21 to 29%...
    148 KB (13,461 words) - 08:19, 1 June 2025
  • Thumbnail for G protein
    G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...
    24 KB (2,754 words) - 17:11, 18 October 2024
  • Thumbnail for Montelukast
    other CYP2C8 substrate drugs, which is most likely due to the high plasma protein binding exhibited by montelukast. Singulair was covered by US Patent No...
    28 KB (2,293 words) - 21:34, 29 May 2025
  • Thumbnail for Dihydrotestosterone
    androgen pathway, it is the first step in the backdoor pathway. The plasma protein binding of DHT is more than 99%. In men, approximately 0.88% of DHT is unbound...
    67 KB (6,840 words) - 20:36, 29 May 2025
  • Thumbnail for Amlodipine
    and steady-state plasma concentrations are achieved after 7 to 8 days of daily dosing. In the blood it has high plasma protein binding of 97.5%. Its long...
    45 KB (4,049 words) - 19:56, 29 May 2025
  • Thumbnail for C4b-binding protein
    C4b-binding protein (C4BP) is a protein complex involved in the complement system where it acts as inhibitor. C4BP has an octopus-like structure with...
    3 KB (341 words) - 12:54, 28 September 2024
  • Thumbnail for Ertapenem
    blood plasma are reached after about 2.3 hours. In the blood, 85–95% of ertapenem are bound to plasma proteins, mostly albumin. Plasma protein binding is...
    20 KB (1,723 words) - 20:45, 29 May 2025
  • Thumbnail for Serum albumin
    tissues. It also acts as a plasma carrier by non-specifically binding several hydrophobic steroid hormones and as a transport protein for hemin and fatty acids...
    8 KB (793 words) - 11:34, 3 December 2023
  • Thumbnail for Orosomucoid
    Orosomucoid (category Acute-phase proteins)
    AAG) is an acute phase protein found in plasma. Orosomucoid was discovered over 70 years ago and belongs to the lipocalin protein family. There are two...
    16 KB (1,776 words) - 16:01, 23 May 2025
  • Thumbnail for Heart-type fatty acid binding protein
    Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene...
    24 KB (3,008 words) - 05:39, 29 September 2023
  • Thumbnail for Naltrexone
    in time to peak concentrations with repeated administration. The plasma protein binding of naltrexone is about 20% over a naltrexone concentration range...
    108 KB (10,614 words) - 21:36, 29 May 2025