Plasma protein binding refers to the degree to which medications attach to blood proteins within the blood plasma. A drug's efficacy may be affected by...
8 KB (1,083 words) - 13:38, 25 May 2025
Clearance (pharmacology) (redirect from Renal plasma clearance)
that exhibit substantial plasma protein binding, clearance is generally dependent on the total concentration (free + protein-bound) and not the free concentration...
15 KB (1,925 words) - 14:35, 4 June 2025
cells in the seminiferous tubules of the testis, it is called androgen-binding protein (ABP). Other steroid hormones such as progesterone, cortisol, and other...
57 KB (4,574 words) - 00:37, 18 December 2024
in the tissues. The binding between a drug and plasma protein is rarely specific and is usually labile and reversible. The binding generally involves ionic...
9 KB (1,433 words) - 01:53, 29 August 2023
plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein...
9 KB (1,132 words) - 01:43, 6 November 2024
Pappalysin-1 (redirect from Pregnancy-associated plasma protein A)
known as pregnancy-associated plasma protein A, and insulin-like growth factor binding protein-4 protease is a protein encoded by the PAPPA gene in humans...
5 KB (562 words) - 10:00, 27 March 2024
Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately...
16 KB (2,039 words) - 05:39, 12 May 2025
plasma protein binding of cetirizine has been found to be 93 to 96% across a range of 25 to 1,000 ng/mL independent of concentration. Plasma protein binding...
39 KB (3,455 words) - 02:16, 22 May 2025
Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol. Assessment of retinol-binding protein...
13 KB (1,604 words) - 06:38, 2 June 2025
Euthyroid sick syndrome (section Binding proteins)
diseases. It is typically associated with high-T3 syndrome, increased plasma protein binding of thyroid hormones, and an elevated set point of the homeostatic...
31 KB (3,385 words) - 01:03, 28 April 2025
Sertraline is highly plasma protein bound (98.5%) across a concentration range of 20 to 500 ng/mL. Despite the high plasma protein binding, sertraline and...
106 KB (10,805 words) - 11:35, 4 June 2025
vary as much as tenfold between different patients. Clonazepam has plasma protein binding of 85%. Clonazepam passes through the blood–brain barrier easily...
78 KB (7,591 words) - 23:58, 29 May 2025
Lipopolysaccharide binding protein (LBP) is a protein that in humans is encoded by the LBP gene. LBP is a soluble acute-phase protein that binds to bacterial...
12 KB (1,454 words) - 17:56, 21 December 2023
molecular weight and lack of plasma protein binding, these techniques have the benefit of removing metformin from the blood plasma, preventing further lactate...
158 KB (15,083 words) - 23:45, 2 June 2025
ligand binding assay techniques were used extensively to quantify hormone or hormone receptor concentrations in plasma or in tissue. The ligand-binding assay...
33 KB (4,118 words) - 11:15, 25 May 2025
indicator of thyroid status in the presence of abnormalities in plasma protein binding. This test is rarely used now that reliable free thyroxine and free...
40 KB (3,677 words) - 16:50, 6 November 2024
plasma steroid hormone-binding proteins such as sex hormone-binding globulin and corticosteroid-binding globulin. It may play a role in the protein functions...
16 KB (2,008 words) - 05:48, 8 March 2025
occasionally, also low TSH concentrations, low-T4 syndrome and impaired plasma protein binding of thyroid hormones. This endocrine pattern is referred to as euthyroid...
29 KB (2,926 words) - 16:46, 30 March 2025
females. The plasma protein binding of testosterone is 98.0 to 98.5%, with 1.5 to 2.0% free or unbound. It is bound 65% to sex hormone-binding globulin (SHBG)...
150 KB (15,796 words) - 18:42, 23 May 2025
these substances also cross the placenta and enter breast milk. The plasma protein binding of pseudoephedrine has been reported to be approximately 21 to 29%...
148 KB (13,461 words) - 08:19, 1 June 2025
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...
24 KB (2,754 words) - 17:11, 18 October 2024
other CYP2C8 substrate drugs, which is most likely due to the high plasma protein binding exhibited by montelukast. Singulair was covered by US Patent No...
28 KB (2,293 words) - 21:34, 29 May 2025
androgen pathway, it is the first step in the backdoor pathway. The plasma protein binding of DHT is more than 99%. In men, approximately 0.88% of DHT is unbound...
67 KB (6,840 words) - 20:36, 29 May 2025
and steady-state plasma concentrations are achieved after 7 to 8 days of daily dosing. In the blood it has high plasma protein binding of 97.5%. Its long...
45 KB (4,049 words) - 19:56, 29 May 2025
C4b-binding protein (C4BP) is a protein complex involved in the complement system where it acts as inhibitor. C4BP has an octopus-like structure with...
3 KB (341 words) - 12:54, 28 September 2024
blood plasma are reached after about 2.3 hours. In the blood, 85–95% of ertapenem are bound to plasma proteins, mostly albumin. Plasma protein binding is...
20 KB (1,723 words) - 20:45, 29 May 2025
Serum albumin (redirect from Protein albumin)
tissues. It also acts as a plasma carrier by non-specifically binding several hydrophobic steroid hormones and as a transport protein for hemin and fatty acids...
8 KB (793 words) - 11:34, 3 December 2023
Orosomucoid (category Acute-phase proteins)
AAG) is an acute phase protein found in plasma. Orosomucoid was discovered over 70 years ago and belongs to the lipocalin protein family. There are two...
16 KB (1,776 words) - 16:01, 23 May 2025
Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene...
24 KB (3,008 words) - 05:39, 29 September 2023
in time to peak concentrations with repeated administration. The plasma protein binding of naltrexone is about 20% over a naltrexone concentration range...
108 KB (10,614 words) - 21:36, 29 May 2025