• Thumbnail for Proliferating cell nuclear antigen
    Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for...
    55 KB (6,180 words) - 10:18, 9 May 2025
  • Thumbnail for Eukaryotic DNA replication
    polymerase α, DNA polymerase ε, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA) onto chromatin. Within a Xenopus nucleus-free system...
    121 KB (14,916 words) - 04:06, 3 January 2025
  • Thumbnail for Antinuclear antibody
    bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins...
    55 KB (6,260 words) - 16:40, 24 May 2025
  • Thumbnail for Ki-67 (protein)
    Ki-67 (protein) has been shown to interact with CBX3. PCNA - Proliferating Cell Nuclear Antigen, expressed during the DNA synthesis. Immunofluorescent antibody...
    10 KB (1,365 words) - 02:06, 17 June 2024
  • Thumbnail for DNA mismatch repair
    for RFC-dependent loading of the replication sliding clamp, proliferating cell nuclear antigen (PCNA), in an orientation-specific manner, such that one face...
    37 KB (4,466 words) - 20:37, 29 May 2025
  • Thumbnail for AOH1996
    anticancer medication which acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as...
    6 KB (589 words) - 19:43, 22 June 2025
  • Thumbnail for Okazaki fragments
    failures could be lethal to the cell. Further research implicates the supplementary role of proliferating cell nuclear antigen (PCNA) to DNA ligase I's function...
    34 KB (4,470 words) - 07:49, 11 November 2024
  • Similarly, proliferating cell nuclear antigen (PCNA) is a protein associated with cell proliferation that is upregulated in proliferating cells, making it...
    13 KB (1,559 words) - 04:20, 11 June 2025
  • Thumbnail for P21
    P21 (category Cell cycle regulators)
    activity via ubiquitin ligase activity. p21 interacts with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory...
    34 KB (3,931 words) - 20:49, 22 May 2025
  • Thumbnail for Newt
    Conversion from mitosis to meiosis: morphology and expression of proliferating cell nuclear antigen (PCNA) and Dmc1 during newt spermatogenesis. Dev Growth Differ...
    36 KB (3,837 words) - 21:39, 20 June 2025
  • Thumbnail for DNA clamp
    from a specific subunit of DNA polymerase delta called the proliferating cell nuclear antigen (PCNA). The N-terminal and C-terminal domains of PCNA are...
    23 KB (2,044 words) - 07:04, 10 March 2024
  • Thumbnail for Epstein–Barr virus
    Human-leukocyte-antigen class II molecules present in B cells in the endoplasmic reticulum and are degraded. In contrast, EBV from epithelial cells are rich...
    65 KB (6,794 words) - 19:07, 10 June 2025
  • Thumbnail for P53
    P53 (redirect from Antigen NY-CO-13)
    Prosperi E (December 2001). "UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication...
    131 KB (14,423 words) - 10:16, 24 June 2025
  • Thumbnail for Homology directed repair
    strand by PCNA (Proliferating Cell Nuclear Antigen). PCNA forms typical patterns in the nucleus of the cell through which the current cell cycle can be determined...
    9 KB (1,265 words) - 11:50, 29 October 2024
  • Thumbnail for Epigenetics
    somatic cells, localizes to replication foci, has a 10–40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA)...
    159 KB (18,196 words) - 21:55, 19 June 2025
  • Thumbnail for DNA repair
    polymerases. A bypass platform is provided to these polymerases by Proliferating cell nuclear antigen (PCNA). Under normal circumstances, PCNA bound to polymerases...
    132 KB (16,142 words) - 16:06, 11 June 2025
  • Thumbnail for POLDIP2
    delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation...
    8 KB (891 words) - 21:04, 13 October 2022
  • Thumbnail for MSH3
    dimerization, allowing MutSβ to bind to DNA and perform MMR. Proliferating cell nuclear antigen (PCNA) is a protein involved in post-replication MMR. It has...
    17 KB (2,080 words) - 11:40, 15 November 2024
  • Thumbnail for Flap structure-specific endonuclease 1
    "Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair". Biochemistry...
    23 KB (2,642 words) - 21:34, 20 February 2024
  • exhibits increased processivity when interacting with the proliferating cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor...
    2 KB (259 words) - 21:21, 11 December 2023
  • Thumbnail for Terminal deoxynucleotidyl transferase
    negatively regulated by direct interaction with proliferating cell nuclear antigen". Genes to Cells. 6 (9): 815–24. doi:10.1046/j.1365-2443.2001.00460...
    30 KB (3,557 words) - 05:39, 17 August 2024
  • reassociate with the DNA. An example of such a DNA clamp is PCNA (proliferating cell nuclear antigen) found in S. cervesiae. Multiple DNA polymerases have specialized...
    6 KB (826 words) - 20:25, 10 September 2023
  • topoisomerase II A, the FLAP endonuclease and the processing factor proliferating cell nuclear antigen. Other proteins include DNA dependent RNA polymerase II and...
    28 KB (3,021 words) - 03:23, 26 May 2025
  • Thumbnail for DNA polymerase
    and POLD4 creating the other subunits that interact with Proliferating Cell Nuclear Antigen (PCNA), which is a DNA clamp that allows Pol δ to possess...
    59 KB (7,106 words) - 00:05, 4 June 2025
  • Thumbnail for Multiple myeloma
    typically show foci of EBV+ cells with the appearance of rapidly proliferating immature or poorly differentiated plasma cells. The cells express products of EBV...
    129 KB (13,217 words) - 16:50, 25 June 2025
  • Thumbnail for NF-κB
    Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription...
    90 KB (9,838 words) - 00:45, 26 May 2025
  • Thumbnail for Bowhead whale
    whale's ability to live longer are the ERCC1 gene and the proliferating cell nuclear antigen (PCNA) gene. ERCC1 is linked to DNA repair and increased cancer...
    64 KB (7,044 words) - 05:52, 15 June 2025
  • Thumbnail for Retinoblastoma protein
    which push the cell through the cell cycle by activating cyclin-dependent kinases, and a molecule called proliferating cell nuclear antigen, or PCNA, which...
    79 KB (9,501 words) - 00:55, 6 March 2025
  • Thumbnail for Mantle cell lymphoma
    term 'mantle cell lymphoma' was first adopted by Raffeld and Jaffe in 1991. MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal...
    43 KB (4,654 words) - 21:25, 29 May 2025
  • Thumbnail for Shope papilloma virus
    layer cells, and not deeper down in proliferating epithelial cells. In domesticated rabbits, the viral antigens were present in much smaller quantity...
    16 KB (1,950 words) - 15:13, 19 June 2025