• Thumbnail for Repulsive guidance molecule A
    Repulsive guidance molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A...
    10 KB (1,138 words) - 04:41, 15 July 2025
  • Thumbnail for Repulsive guidance molecule B
    Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein...
    5 KB (603 words) - 22:14, 15 July 2025
  • Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa...
    2 KB (141 words) - 10:21, 17 October 2022
  • Elezanumab (category Drugs that are a monoclonal antibody)
    names AE12-1Y-QL and ABT-555) is a fully human monoclonal antibody developed by AbbVie against repulsive guidance molecule A (RGMa). It has been tested in...
    5 KB (315 words) - 22:42, 25 June 2025
  • Thumbnail for Hemojuvelin
    Hemojuvelin (HJV), also known as repulsive guidance molecule C (RGMc) or hemochromatosis type 2 protein (HFE2), is a membrane-bound and soluble protein...
    14 KB (1,834 words) - 14:58, 21 December 2023
  • takes place from a region called the growth cone and reaching the axon target is accomplished with relatively few guidance molecules. Growth cone receptors...
    33 KB (4,365 words) - 08:32, 24 May 2025
  • for elongation of each axon. These growth cones find signal molecules which act as guidance cues and form synapses. Connections formed between neurites...
    55 KB (6,888 words) - 06:05, 9 June 2025
  • Thumbnail for Organic acid anhydride
    PMC 7078468. PMID 32184239. Bell, Christian (2013). "Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub". Science. 341 (6141): 77–80. Bibcode:2013Sci...
    18 KB (2,083 words) - 15:43, 24 May 2025
  • Thumbnail for List of therapeutic monoclonal antibodies
    Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names...
    146 KB (4,507 words) - 04:33, 1 August 2025
  • Thumbnail for Retinal ganglion cell
    secrete repulsive semaphorin 5a and Slit in a surround fashion, covering the optic nerve which ensures that they remain in the optic nerve. Vax1, a transcription...
    30 KB (3,681 words) - 05:13, 12 May 2025
  • Thumbnail for Human iron metabolism
    2009). "Molecular biology, genetics and biochemistry of the repulsive guidance molecule family". The Biochemical Journal. 422 (3): 393–403. doi:10.1042/BJ20090978...
    46 KB (5,568 words) - 19:37, 28 July 2025
  • Thumbnail for Iron metabolism disorder
    are caused by mutations in the hemojuvelin gene (HJV or RGMc/repulsive guidance molecule c). The exceptions, people who have mutations in the gene for...
    4 KB (365 words) - 23:26, 27 May 2025
  • Thumbnail for Growth cone
    filopodia are bound by a membrane which contains receptors, and cell adhesion molecules that are important for axon growth and guidance. In between filopodia—much...
    15 KB (1,695 words) - 15:26, 29 September 2024
  • Thumbnail for Tropic cues involved in growth cone guidance
    of repulsive guidance. Robo receptors were initially identified in Drosophila melanogaster using a forward genetic screen to search for molecules involved...
    26 KB (3,143 words) - 23:07, 24 May 2025
  • Thumbnail for Netrin
    improper formation of the (TEBs), suggesting that rather than acting as a guidance molecule as in neuronal systems, netrin 1 serves as an adhesive in mammary...
    33 KB (4,169 words) - 20:50, 23 September 2024
  • Thumbnail for DSCAM
    DSCAM (category Protein pages needing a picture)
    homologs of Down syndrome adhesion molecule. Like many neuronal receptors, Dscam proteins have multiple functions, with repulsive and attractive roles that are...
    32 KB (3,767 words) - 16:24, 17 July 2025
  • Thumbnail for NEO1
    the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. GRCh38: Ensembl release 89: ENSG00000067141 – Ensembl...
    6 KB (689 words) - 22:03, 15 July 2025
  • within the target area by a perimeter of cues repulsive to the growth cone. Axons express patterns of cell-surface adhesion molecules that allow them to match...
    9 KB (1,223 words) - 18:52, 5 January 2025
  • Slit (protein) (category Protein pages needing a picture)
    bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268...
    17 KB (1,951 words) - 17:49, 30 March 2025
  • Thumbnail for Lone pair
    109° predicted for a tetrahedral angle, and this can be explained by a repulsive interaction between the lone pairs. Various computational criteria for...
    23 KB (2,957 words) - 08:07, 16 March 2025
  • Thumbnail for Optic chiasm
    Ephrin-B2 is expressed at the chiasm midline by radial glia and acts as a repulsive signal to axons originating from the ventrotemporal retina expressing...
    15 KB (1,715 words) - 00:24, 28 July 2025
  • Fasciclin 2 (category Cell adhesion molecules)
    (Fas2 or FasII) is a 95 kilodalton cell membrane glycoprotein in the immunoglobulin (Ig) – related superfamily of cell adhesion molecules (CAMs). It was first...
    5 KB (556 words) - 19:18, 4 August 2018
  • Slit refers to a secreted protein that is most widely known as a repulsive axon guidance cue, and Robo refers to its transmembrane protein receptor. There...
    34 KB (4,080 words) - 00:05, 27 May 2025
  • not your clients? And lasers, and all these supreme bacteria, all that repulsive filth, until the right moment hidden in safes? Strugatsky, Arkady and...
    61 KB (7,449 words) - 10:02, 28 July 2025
  • Thumbnail for ROBO1
    bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268...
    10 KB (1,234 words) - 18:12, 17 July 2025
  • Thumbnail for Neuronal self-avoidance
    cell-surface interaction into a repulsive response that leads to dendrite separation in da neurons is supported by Matthews et al. (2007) in a study that demonstrated...
    41 KB (5,789 words) - 02:43, 4 July 2025
  • Thumbnail for Netrin 1
    PMID 8978605. S2CID 1008380. Togari A, Mogi M, Arai M, et al. (2001). "Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and...
    10 KB (1,335 words) - 17:35, 17 July 2025
  • UNC-5 (category Protein pages needing a picture)
    polarity required for axon guidance. Recent findings have shown that UNC-129 is also responsible for long range repulsive guidance of UNC-6. This mechanism...
    21 KB (2,577 words) - 04:37, 2 June 2025
  • Thumbnail for Pollen tube
    (October 2000). "Attractive and repulsive interactions between female and male gametophytes in Arabidopsis pollen tube guidance" (PDF). Development. 127 (20):...
    49 KB (6,541 words) - 09:21, 11 July 2025
  • polarity required for axon guidance. Recent findings have shown that UNC-129 is also responsible for long range repulsive guidance of UNC-6. This mechanism...
    21 KB (2,673 words) - 04:10, 2 June 2025