Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically...
60 KB (7,300 words) - 14:35, 22 July 2025
Natural antisense short interfering RNA (natsiRNA) is a type of siRNA. They are endogenous RNA regulators which are between 21 and 24 nucleotides in length...
3 KB (319 words) - 05:05, 31 January 2024
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
140 KB (15,415 words) - 15:34, 18 July 2025
Olpasiran (category Antisense RNA)
Olpasiran (AMG890) is an experimental siRNA (short interfering RNA) therapy designed to lower the level of lipoprotein(a), which is believed to be a causal...
2 KB (234 words) - 20:21, 28 June 2025
levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as...
36 KB (3,842 words) - 17:13, 25 November 2024
A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target...
10 KB (1,291 words) - 02:34, 25 March 2025
Trans-acting siRNA (abbreviated "ta-siRNA" or "tasiRNA") are a class of small interfering RNA (siRNA) that repress gene expression through post-transcriptional...
9 KB (1,153 words) - 05:22, 31 January 2024
EIF2C2 (category RNA interference)
and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing. EIF2C2 has been shown to interact with...
9 KB (1,093 words) - 16:26, 17 July 2025
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
66 KB (7,680 words) - 17:02, 22 July 2025
rasi/piRNA biogenesis.) Double-stranded RNAs capable of silencing repeat elements, then known as repeat associated small interfering RNA (rasiRNA), were...
44 KB (5,243 words) - 05:19, 29 October 2024
for the different types of RNA are listed and explained. List of cis-regulatory RNA elements RNA: Types of RNA Non-coding RNA Gribaldo S, Brochier-Armanet...
20 KB (1,022 words) - 07:09, 12 July 2025
double-stranded RNAs that function as small interfering RNA (siRNA) in the RNA silencing system. By sequestering siRNA, p19 suppresses RNA silencing and...
11 KB (1,172 words) - 03:13, 29 January 2023
Cell-penetrating peptide (category Articles with short description)
maintaining full biological activity. Short interfering RNA (siRNA) is a powerful new tool that can interfere with and silence the expression of specific...
58 KB (7,244 words) - 21:54, 11 July 2025
example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the...
48 KB (5,498 words) - 13:11, 28 December 2024
rearrangement. shRNA: Short hairpin RNA - an RNA that acts similarly to miRNA, regulating gene expression via RISC siRNA: small interfering RNA - an RNA that regulates...
18 KB (1,916 words) - 17:51, 18 July 2025
Lepodisiran (category Small interfering RNA)
Lepodisiran (LY3819469) is a small interfering RNA that was developed to reduce lipoprotein(a) in people at risk of cardiovascular disease. It was developed...
4 KB (208 words) - 15:45, 27 June 2025
Functional genomics (category Articles with short description)
transfection of synthetic ~20-mer short-interfering RNA molecules (siRNAs) or by virally encoded short-hairpin RNAs (shRNAs). RNAi screens, typically performed...
33 KB (4,013 words) - 16:26, 22 July 2025
Tomato bushy stunt virus (category Articles with short description)
RNA silencing pathway, a common form of antiviral defense. The p19 protein binds short interfering RNAs and prevents their incorporation into the RNA-induced...
16 KB (1,813 words) - 00:02, 28 May 2025
in 1994. The company has pioneered the development of short-interfering ribonucleic acid (siRNA) therapeutics for the treatment of rare diseases. Silence...
4 KB (288 words) - 11:06, 23 August 2024
Non-coding DNA (category Articles with short description)
nucleolar RNAs (sno RNAs), microRNAs (miRNAs), short interfering RNAs (siRNAs), PIWI-interacting RNAs (piRNAs), and long noncoding RNAs (lncRNAs). In addition...
41 KB (4,746 words) - 22:12, 24 July 2025
involved in RNA interference: these amplify microRNAs and small temporal RNAs and produce double-stranded RNA using small interfering RNAs as primers....
27 KB (3,112 words) - 13:37, 27 April 2025
Plasmodesma (category Articles with short description)
to transport proteins (including transcription factors), short interfering RNA, messenger RNA, viroids, and viral genomes from cell to cell. One example...
23 KB (2,748 words) - 02:01, 5 June 2025
Gene product (category Articles with short description)
translation. These miRNAs work by binding to a complementary target mRNA sequence to prevent translation from occurring. Short-interfering RNA (siRNA) also works...
9 KB (1,186 words) - 00:53, 1 August 2024
ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)...
99 KB (10,625 words) - 11:19, 19 July 2025
Dicer (category RNA interference)
double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively...
26 KB (3,275 words) - 16:20, 17 July 2025
of both small interfering RNA (siRNA) and micro RNA (miRNA) to prevent mRNA translation and/or degrade mRNA. Small activating RNA (saRNA) represents a...
83 KB (9,546 words) - 15:12, 22 July 2025
triggers mRNA degradation by 5' decapping, 3' poly(A) tail removal, or endonucleolytic cleavage. In metazoans, small interfering RNAs (siRNAs) processed...
52 KB (6,275 words) - 14:39, 28 July 2025
defective interfering (DI) RNA region 3 is an important cis-regulatory region identified in the 3' UTR of Tombusvirus defective interfering particles...
2 KB (145 words) - 22:06, 13 November 2022
Inclisiran (category Small interfering RNA)
heterozygous familial hypercholesterolemia (HeFH). It is a small interfering RNA (siRNA) that acts as an inhibitor of a proprotein convertase, specifically...
23 KB (1,937 words) - 11:44, 3 June 2025
Argonaute (category RNA-binding proteins)
double-stranded RNA (dsRNA, often found in viruses and small interfering RNA) molecules into short double stranded fragments of around 20 nucleotide siRNAs. The...
17 KB (2,024 words) - 13:42, 17 July 2025