The structure–activity relationship (SAR) is the relationship between the chemical structure of a molecule and its biological activity. This idea was first...

Quantitative structure–activity relationship (QSAR) models are regression or classification models used in the chemical and biological sciences and engineering...

The structure–activity relationships (SAR) of anabolic steroids (AAS) have been extensively studied. Addition of a methyl or ethyl group at the C17α position...

cardioprotective than the other medications used to treat diabetes. The structure-activity relationship (SAR) of gliflozins is not fully understood. The most commonly...

discovered in structure-activity relationship studies. The class of substances is defined chemically by the presence of the benzimidazole core structure and pharmacologically...

Milnacipran is structurally different from other SNRIs. The structure activity relationship of milnacipran derivatives at the transporter level is still...

benzodiazepine derivatives have been synthesised and their structure-activity relationships explored in detail. This chart contains binding data for benzodiazepines...

biochemistry, the conformation–activity relationship is the relationship between the biological activity and the chemical structure or conformational changes...

that time. As mentioned in the structure-activity relationship chapter above, certain groups are important for the activity. The most important groups are...

Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships". Archived from the original on 2010-11-04. Campbell NA, Reece...

of quantitative structure–activity relationship and quantitative structure property relationship values, used to predict the activity of compounds from...

osmotic-lysis. The molecular structure of cephalosporin can be altered in various ways to improve in vitro stability, anti-bacterial activity and resistance against...

SF, Anwar U (25 July 2018). "Tetracycline: Classification, Structure Activity Relationship and Mechanism of Action as a Theranostic Agent for Infectious...

can be made to the 1,5-diarylpyrazole moiety to deduce the structure-activity relationship of celecoxib. A para-sulfamoylphenyl at position 1 of the pyrazole...

receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents"...

confirm relationships between structure and biological activity. Agonists generate responses from living tissues. Therefore, their activity depends both...

but lacked sufficient affinity for the NK1 receptor, despite structure-activity relationship (SAR) studies that were performed. This series proved to have...

groups leads to loss of activity The overall size of the molecule cannot be altered much. Bigger molecules have poorer activity The hypothesis states that...

which is dysfunctional in Parkinson's disease. Establishing the relationship between structure and efficacy for ligands of adenosine receptors has proven to...

cyclohexyl ester derivatives make the most difference in the structure activity relationship as they show as much as 10-fold improvement in potency. Based...

memantine, have been synthesized in order to perform a detailed structure activity relationship (SAR) of these novel drugs. One class, containing a nitro (NO2)...

a set of known active and known inactive compounds. SAR's (structure activity relationship) where data is treated qualitatively and can be used with structural...

that were discovered using conventional pharmacological methods. Its structure was discovered later as a part of an effort to identify a commonly expressed...

analysis (CoMFA) to establish three-dimensional quantitative structure-activity relationship (3D QSAR), while searching for novel active pharmacophores...

Morphinan is the prototype chemical structure of a large chemical class of psychoactive drugs, consisting of opiate analgesics, cough suppressants, and...

For a cholinergic agent, the following criteria describe the structure activity relationship: Ing's Rule of 5: there should be no more than five atoms between...

attached to planar aromatic structures. Heterocyclic nitrogen atom is an important factor for NSAIs structure-activity relationship as it interacts with heme...

Pottie E, Cannaert A, Stove CP (October 2020). "In vitro structure-activity relationship determination of 30 psychedelic new psychoactive substances...

heteroaromatic ring. Structure-activity relationship (SAR) studies of LGIC receptor ligands are valuable to investigate their structure and function. An antagonist-like...

spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted...