The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz...

Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span...

common name of 'Two-pore-domain potassium channels', these channels have only one pore but two pore domains per subunit. Two-pore channels include ligand-gated...

two-pore-domain potassium channels, which confusingly have only one pore and were named for the fact that each subunit has two P (pore) domains in its primary...

"Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel". Neuropharmacology. 40 (4): 551–9. doi:10.1016/S0028-3908(00)00189-1...

Potassium channel blockers are agents which interfere with conduction through potassium channels. Potassium channel blockers used in the treatment of...

Long SB (January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science. 335 (6067): 432–6. Bibcode:2012Sci...335....

events organized by artist Oliver Herring Two-pore-domain potassium channel, a family of potassium ion channels Task (miniseries), a 2025 American crime...

conductance pore. Based on sequence homology of the hydrophobic transmembrane cores, the alpha subunits of voltage-gated potassium channels are grouped...

studied extensively in ion channel research. The pH activated protein possesses two transmembrane segments and a highly selective pore region, responsible for...

Structurally, BK channels are homologous to voltage- and ligand-gated potassium channels, having a voltage sensor and pore as the membrane-spanning domain and a...

distinguish it from outward potassium currents. Inward rectifiers also differ from tandem pore domain potassium channels, which are largely responsible...

family of potassium channels. KvLQT1 is made of six membrane-spanning domains S1-S6, two intracellular domains, and a pore loop. The KvLQT1 channel is made...

lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers...

K2P may refer to: Two-pore-domain potassium channel (K2P), a family of cell membrane leak channels Kimura's two parameter model (K2P model), a model of...

transmembrane domains arranged around a central pore; these four domains are part of a single α-subunit in the case of most Na+ and Ca2+ channels, whereas...

and into the cytoplasm. Each channel consists of domains which span the plasma membrane, forming the K+-selective pore region through which the K+ ions...

oxide and cyclopropane, xenon activates the two-pore domain potassium channel TREK-1. A related channel TASK-3 also implicated in the actions of inhalation...

sodium channels in the membrane. The sodium influx eventually overtakes the potassium efflux (via the two-pore-domain potassium channels or leak channels, initiating...

transmembrane helices from the 4 domains line up to form the channel proper; S5 and S6 helices are thought to line the inner pore surface, while S1–4 helices...

SK channels (small conductance calcium-activated potassium channels) are a subfamily of calcium-activated potassium channels. They are so called because...

3 The structure of the pore is similar to other ion channels that contain P-loops. The P-loop enters the membrane of the pore from the extracellular side...

humans is encoded by the KCNK13 gene. It is a potassium channel containing two pore-forming P domains. K2P13.1 was first discovered in 2000 from a rat...

There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be homotetramers or heterotetramers;...

sodium channels, the region linking domains III and IV is also important for channel function. This DIII-IV linker is responsible for wedging the pore gate...

subunits have two transmembrane spans and form the channel's pore. The SUR subunits have three additional transmembrane domains, and contain two nucleotide-binding...

or pH. The CLC family of chloride channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members...

ion channels and signaling cascades. Interactions with TREK1 potassium channels are a prime example of this relationship. TREK1 is a two-pore channel that...

heterologously expressed hERG potassium channel comprises four identical alpha subunits, which form the channel's pore through the plasma membrane. Each...

experimental data suggests that modulation of two-pore domain potassium channels, or voltage-gated sodium channels may also account for some of the actions...