Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical...
74 KB (8,396 words) - 00:09, 26 April 2024
contributed an understanding of protein folding and structure mediated by hydrophobic interactions. The first protein to be sequenced was insulin, by...
99 KB (11,210 words) - 04:06, 20 May 2024
Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions...
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biology research in order to track protein interactions in real time. The first fluorescent tag, green fluorescent protein (GFP), was isolated from Aequorea...
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activator like effectors. Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held...
21 KB (2,563 words) - 05:45, 4 September 2023
Protein–protein interaction screening refers to the identification of Protein–protein interaction with high-throughput screening methods such as computer-...
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of skin penetration. Protein A can inflame lung tissue by binding to tumor necrosis factor 1 (TNFR-1) receptors. This interaction has been shown to play...
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affects a large portion of proteins. Even if a protein is not phosphorylated itself, its interactions with other proteins may be regulated by phosphorylation...
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native structure of a protein. Tertiary structure of a protein involves a single polypeptide chain; however, additional interactions of folded polypeptide...
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Protein biosynthesis (or protein synthesis) is a core biological process, occurring inside cells, balancing the loss of cellular proteins (via degradation...
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G-protein activation. However, the possibility for interaction does allow for G-protein-independent signaling to occur. There are three main G-protein-mediated...
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to investigate protein–protein interactions which are the physical contacts of high specificity established between two or more protein molecules involving...
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chain. Protein complexes are a form of quaternary structure. Proteins in a protein complex are linked by non-covalent protein–protein interactions. These...
25 KB (2,841 words) - 17:04, 19 May 2024
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest...
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between a protein and a functional, proteinaceous unit was difficult to elucidate. More recently, people refer to protein–protein interaction when discussing...
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website. Biology portal Protein design Protein function prediction Protein–protein interaction prediction Gene prediction Protein structure prediction software...
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precipitate a protein. Addition of a neutral salt, such as ammonium sulfate, compresses the solvation layer and increases protein–protein interactions. As the...
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non-covalent interactions, such as hydrogen bonding, ionic interactions, Van der Waals forces, and hydrophobic packing. To understand the functions of proteins at...
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Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending...
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A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases...
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chromosome stability, its interaction with the cellular transcriptome, its interaction with other cytoskeletal or synaptic proteins, its involvement in myelination...
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G protein coupled receptors modeling, activation, interactions and virtual screening (1st ed.). Academic Press. 7. Matthews, Jacqueline M. Protein Dimerization...
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outwards, allowing dipole–dipole interactions with the solvent, which explains the molecule's solubility. Globular proteins are only marginally stable because...
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assembly of multi-protein complexes by increasing the probability of any appropriate protein–protein interactions. Peripheral membrane proteins may interact...
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or whole organisms. Protein purification is vital for the specification of the function, structure and interactions of the protein of interest. The purification...
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pathway DNA-binding protein STAT Inhibitors Key steps of the JAK-STAT pathway Structure of the amino-terminal protein interaction domain of STAT-4. Vinkemeier...
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molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a...
29 KB (3,499 words) - 07:16, 20 February 2024
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside...
52 KB (6,394 words) - 03:48, 19 March 2024
Antifreeze proteins (AFPs) or ice structuring proteins refer to a class of polypeptides produced by certain animals, plants, fungi and bacteria that permit...
52 KB (6,239 words) - 00:37, 29 December 2023
Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being...
21 KB (2,519 words) - 22:32, 23 March 2024