Neuraminidase inhibitors inhibit enzymatic activity of the enzyme neuraminidase (sialidase). These types of inhibitors have been introduced as anti-influenza...
30 KB (4,066 words) - 15:34, 5 June 2025
Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are a commonly used antiviral drug type against influenza...
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and colleagues as NEU1 inhibitors. Glycoside hydrolase family 33 Neuraminidase inhibitors Hemagglutinin (influenza) "WEHI History: 1957 Discovery of Neuraminidase...
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the first JAK inhibitor, ruxolitinib, to treat a skin condition. Some JAK1 inhibitors are based on a benzimidazole core. JAK3 inhibitors target the catalytic...
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George Hirst (virologist) (category Fellows of the American Academy of Arts and Sciences)
the host cell. Neuraminidase is the target of the neuraminidase inhibitor class of antiviral drugs, which include oseltamivir (Tamiflu) and zanamivir (Relenza)...
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Influenza (redirect from Consequencies of the spanish flu)
(NA) inhibitors and M2 inhibitors. Baloxavir marboxil is a notable exception, which targets the endonuclease activity of the viral RNA polymerase and can...
115 KB (13,216 words) - 15:11, 3 May 2025
X, Kim CU (June 2000). "Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor". Current Medicinal Chemistry...
104 KB (11,579 words) - 19:29, 18 September 2024
Enzyme (redirect from Lock-and-key model (enzyme))
PMID 20640225. Endo A (November 1992). "The discovery and development of HMG-CoA reductase inhibitors". Journal of Lipid Research. 33 (11): 1569–1582. doi:10...
99 KB (10,086 words) - 19:06, 23 May 2025
Influenza A virus (section Structure and genetics)
hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. Almost all possible combinations of H (1 through 16) and N (1 through 11) have been...
60 KB (6,118 words) - 14:20, 31 March 2025
Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease...
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Antiviral drug (section Uncoating inhibitors)
from changes occurring in neuraminidase and hemagglutinin proteins on the viral surface. Currently, neuraminidase inhibitors (NAIs) are the most frequently...
56 KB (6,758 words) - 19:59, 29 May 2025
Influenza B virus (category Taxonbars of monotypic genera missing species)
projections are made of hemagglutinin and neuraminidase. The influenza B virus genome is 14,548 nucleotides long and consists of eight segments of linear negative-sense...
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on a broad range of influenza virus subtypes and efficacy against influenza viruses that are resistant to neuraminidase inhibitors like oseltamivir....
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H5N1 genetic structure (redirect from Genetic structure of H5N1)
antiviral drugs Tamiflu and Relenza work by inhibiting some strains of neuraminidase. M codes for the matrix proteins (M1 and M2) that, along with the...
28 KB (3,764 words) - 16:53, 25 December 2024
neuraminidase inhibitors, such as zanamivir and oseltamivir, polymerase acidic endonuclease inhibitors such as baloxavir marboxil, or inhibitors of the...
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Dynamic combinatorial chemistry (category Drug discovery)
dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selective pressure of the biological target". J. Med. Chem. 46 (3):...
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(A-E) and may be treated with antiviral drugs depending on the type of infection. Some influenza A and B viruses have become resistant to neuraminidase inhibitors...
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Baloxavir marboxil (section Mechanism of action)
is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir. Baloxavir marboxil is a substituted pyridone derivative of a polycyclic family...
32 KB (2,802 words) - 20:05, 29 May 2025
Recombination between segments that encode for hemagglutinin and neuraminidase of avian and human influenza virus segments have resulted in worldwide influenza...
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Paramyxoviridae (category Wikipedia articles in need of updating from March 2020)
(Hemagglutinin-neuraminidase) attachment proteins occur in respiroviruses, rubulaviruses and avulaviruses. These possess both haemagglutination and neuraminidase activity...
18 KB (2,023 words) - 16:13, 16 April 2025
RNA therapeutics (category CS1 maint: DOI inactive as of March 2025)
containing an mRNA adjuvant and naked IVT mRNA encoding influenza hemagglutinin antigen only or in combination with neuraminidase encoding IVT mRNA. For example...
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Raymond C. Stevens (category University of Southern Maine alumni)
researchers at Gilead on the structural studies of neuraminidase inhibitors that eventually became Tamiflu, and later partnered with Roche. After the initial...
40 KB (5,657 words) - 22:05, 29 March 2025
Virus (redirect from Assembly and budding)
drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses". Proceedings of the National Academy of Sciences of the United States of America...
155 KB (18,324 words) - 04:54, 3 June 2025
Spanish flu (redirect from Influenza epidemic of 1918)
CDC (17 December 2019). "The Discovery and Reconstruction of the 1918 Pandemic Virus". Centers for Disease Control and Prevention. Archived from the...
239 KB (25,288 words) - 09:14, 4 June 2025
Lectin (section Bacteria and viruses)
Allen (2002). "Role of the Hemagglutinin-Neuraminidase Protein in the Mechanism of Paramyxovirus-Cell Membrane Fusion". Journal of Virology. 76 (24): 13028–13033...
30 KB (3,037 words) - 01:01, 21 May 2025
Murine respirovirus (redirect from Hemagglutinating virus of Japan)
the surface of malignant cells. Hemagglutinin-neuraminidase (HN) is a single protein that induces hemagglutination and possesses neuraminidase (sialidase)...
297 KB (32,094 words) - 15:13, 22 May 2025
Tryon Island (category Islands of Queensland)
GlaxoWellcome, Eli Lilly and Company, Abbott Labs., ZymeTx Corporation and Pfizer Ltd. in the design and synthesis of novel neuraminidase inhibitors which these companies...
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research and the discovery of viral neuraminidase. Sam Granick (1909–1977). American biochemist at the Rockefeller University, known for his studies of ferritin...
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2009 swine flu pandemic (redirect from 2009 Mexico and U.S. outbreak)
Mar C (December 2009). "Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis". BMJ. 339:...
161 KB (16,869 words) - 22:12, 22 May 2025
Influenza A virus subtype H5N1 (category Subtypes of Influenza A virus)
recommended are neuraminidase inhibitors, such as zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs can reduce the severity of symptoms if taken...
72 KB (8,475 words) - 21:10, 29 May 2025