• Thumbnail for Low-affinity nerve growth factor receptor
    The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR...
    37 KB (4,235 words) - 09:21, 21 December 2023
  • Thumbnail for Nerve growth factor
    Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival...
    23 KB (2,786 words) - 23:53, 26 April 2024
  • Thumbnail for Brain-derived neurotrophic factor
    responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). It may...
    45 KB (5,339 words) - 00:15, 22 March 2024
  • Thumbnail for Tropomyosin receptor kinase A
    Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming...
    27 KB (3,264 words) - 05:43, 13 April 2024
  • Thumbnail for Cell surface receptor
    High affinity neurotrophin receptors Ephrin receptors Integrins Low Affinity Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll-like...
    21 KB (2,456 words) - 22:14, 21 November 2023
  • Thumbnail for Hepatocyte growth factor receptor
    Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
    58 KB (6,923 words) - 01:30, 3 May 2024
  • Thumbnail for Fibroblast growth factor receptor 2
    This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. FGFR2 has important...
    14 KB (1,748 words) - 14:34, 11 December 2023
  • neurotrophic factor receptors are the p75 and the "Trk" families of Tyrosine kinases receptors. p75 is a low affinity neurotrophin receptor, to which all...
    5 KB (670 words) - 17:28, 23 January 2021
  • Thumbnail for Epidermal growth factor
    Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
    17 KB (1,735 words) - 03:22, 28 February 2024
  • Thumbnail for Neurotrophin-3
    binds a second-receptor type besides Trk receptors, called the LNGFR (for "low affinity nerve growth factor receptor). TrkC is a receptor tyrosine kinase...
    14 KB (1,816 words) - 04:39, 31 October 2023
  • Thumbnail for Neurotrophin
    of receptors for neurotrophins: p75 and the "Trk" family of Tyrosine kinases receptors. Nerve growth factor (NGF), the prototypical growth factor, is...
    27 KB (3,069 words) - 02:53, 24 May 2024
  • Thumbnail for Tropomyosin receptor kinase C
    is one other NT-3 receptor family besides the Trks (TrkC & TrkB), called the "LNGFR" (for "low affinity nerve growth factor receptor"). As opposed to TrkC...
    32 KB (3,936 words) - 03:00, 29 January 2024
  • Thumbnail for Tropomyosin receptor kinase B
    Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type...
    40 KB (4,321 words) - 10:20, 23 March 2024
  • Thumbnail for Tumor necrosis factor
    The binding of TNF to its receptor and its displacement by LT confirmed the functional homology between the two factors. The sequential and functional...
    52 KB (6,302 words) - 07:19, 27 April 2024
  • Thumbnail for Fibroblast growth factor receptor 3
    Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster of differentiation...
    17 KB (1,955 words) - 06:59, 15 April 2024
  • Thumbnail for Placental growth factor
    Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a member of the VEGF (vascular...
    15 KB (1,923 words) - 12:01, 27 September 2023
  • Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells...
    40 KB (4,578 words) - 20:20, 10 March 2024
  • Thumbnail for TRAF2
    CD40, CFLAR, CHUK, Caveolin 1, EDARADD, HIVEP3, IKK2, Low affinity nerve growth factor receptor, MAP3K14, MAP3K1, MAP3K7IP2, MAP4K2, MAP4K5, RANK, RIPK1...
    29 KB (3,427 words) - 04:28, 25 December 2023
  • Thumbnail for NGFRAP1
    gene. NGFRAP1 has been shown to interact with YWHAE and Low affinity nerve growth factor receptor. GRCh38: Ensembl release 89: ENSG00000166681 – Ensembl...
    6 KB (847 words) - 23:15, 4 September 2022
  • Thumbnail for Somatostatin
    Pasireotide is somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. Six somatostatin...
    23 KB (2,566 words) - 00:09, 5 April 2024
  • into co-receptors for p75, such as the sortilin co-receptor, has implicated sortilin in connection to neurotrophins, a type of nerve growth factor. The p75...
    21 KB (3,129 words) - 20:16, 11 July 2023
  • inhibitory factor receptor Leukocyte extravasation Leukocyte-promoting factor Linear epitope Lipid A Lipopolysaccharide binding protein Low-affinity nerve growth...
    13 KB (1,237 words) - 01:24, 15 January 2024
  • Thumbnail for NMDA receptor
    successful NMDA receptor antagonists for neurodegenerative diseases continued and focused on developing low affinity blockers. However the affinity could not...
    107 KB (12,051 words) - 23:49, 26 April 2024
  • Thumbnail for Olfactory ensheathing cell
    OECs have been identified with high or low cell surface expression of low-affinity nerve growth factor receptor (p75). Neuroscience Neuroglia Olfaction...
    18 KB (2,259 words) - 09:20, 18 July 2023
  • Thumbnail for Μ-opioid receptor
    The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins...
    22 KB (2,424 words) - 08:47, 18 May 2024
  • Thumbnail for Prolactin
    cycle-related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor, binding to cytokine-like receptors, it influences hematopoiesis...
    56 KB (5,820 words) - 00:14, 19 May 2024
  • Thumbnail for NDN (gene)
    has been shown to interact with: E2F1, HNRNPU, IL1A, Low affinity nerve growth factor receptor, NUCB2, and P53 ENSG00000288364 GRCh38: Ensembl release...
    11 KB (1,275 words) - 18:10, 27 December 2023
  • Thumbnail for Dehydroepiandrosterone
    Dehydroepiandrosterone (category GABAA receptor negative allosteric modulators)
    TrkA and p75NTR, receptors of neurotrophins like nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), with high affinity. DHEA was subsequently...
    42 KB (3,935 words) - 04:01, 30 April 2024
  • Thumbnail for LRP1
    Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster...
    32 KB (3,564 words) - 02:52, 28 March 2024
  • Thumbnail for GRB2
    Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2...
    82 KB (9,365 words) - 15:39, 31 March 2024