• Specialized pro-resolving mediators (SPM, also termed specialized proresolving mediators) are a large and growing class of cell signaling molecules formed...
    67 KB (7,271 words) - 18:24, 9 February 2025
  • Thumbnail for Resolvin
    Resolvins are specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid...
    11 KB (1,311 words) - 13:05, 28 June 2025
  • Thumbnail for Eicosanoid
    inflammation-resolving actions in diverse animal models. They therefore appear to function in a manner similar to specialized pro-resolving mediators although...
    86 KB (9,651 words) - 06:41, 2 November 2024
  • Thumbnail for Lipoxin
    categorized as nonclassic eicosanoids and members of the specialized pro-resolving mediator (SPM) family of polyunsaturated fatty acid (PUFA) metabolites...
    39 KB (4,383 words) - 21:16, 25 May 2025
  • neuroprotectins (See Specialized pro-resolving mediators). These mediators possess a broad range of overlapping activities which act to resolve inflammation;...
    8 KB (832 words) - 21:25, 24 May 2025
  • the pro-inflammatory and pro-allergic activities of their arachidonic acid-derived counterparts. RvE1 and ReV2 are specialized pro-resolving mediators that...
    61 KB (7,557 words) - 12:23, 1 July 2025
  • Thumbnail for 15-Hydroxyeicosatetraenoic acid
    (5-oxo-15(S)-HETE), a subset of specialized pro-resolving mediators viz., the lipoxins, a class of pro-inflammatory mediators, the eoxins, and other products...
    67 KB (7,349 words) - 10:56, 9 June 2025
  • Thumbnail for Mediation
    an independent third party, the mediator, assists disputing parties in resolving conflict through the use of specialized communication and negotiation techniques...
    76 KB (9,854 words) - 06:40, 29 May 2025
  • docosanoid metabolites of DPA and n-3 DHA are members of the specialized pro-resolving mediators class of polyunsaturated fatty acid metabolites that possess...
    10 KB (1,125 words) - 19:29, 10 April 2024
  • Thumbnail for Lipoxygenase
    resolvins are also classified as specialized pro-resolving mediators. Arachidonate 12-lipoxygenase (ALOX12) (EC 1.13.11.31; InterPro: IPR001885), also termed...
    32 KB (3,890 words) - 12:37, 2 July 2025
  • Thumbnail for Arachidonic acid 5-hydroperoxide
    5-hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid; or c) the specialized pro-resolving mediators of inflammation, lipoxin A4 and lipoxin B4. Haeggström JZ...
    3 KB (160 words) - 21:43, 1 April 2024
  • similar to specialized pro-resolving mediators to dampen and reverse inflammatory responses by neutralizing and then speeding the clearance of pro-inflammatory...
    70 KB (7,684 words) - 06:35, 2 June 2025
  • Thumbnail for Docosahexaenoic acid
    synthesize DHA. DHA can be metabolized into DHA-derived specialized pro-resolving mediators (SPMs), DHA epoxides, electrophilic oxo-derivatives (EFOX)...
    31 KB (3,200 words) - 00:48, 20 June 2025
  • University of London. The focus of Serhan's research are Specialized Pro-Resolving Mediators (SPMs), which are "inflammation-fighting molecules in the...
    7 KB (647 words) - 11:10, 20 August 2024
  • Thumbnail for Maresin
    anti-inflammatory, pro-resolving, protective, and pro-healing properties similar to a variety of other members of the specialized proresolving mediators (SPM) class...
    15 KB (1,623 words) - 20:55, 4 April 2024
  • Thumbnail for ALOX15
    have been classified as specialized proresolvin mediators. Base on the analogy to docosahexaenoic acid metabolism to resolving D's, it is presumed that...
    44 KB (5,708 words) - 00:14, 16 June 2025
  • Thumbnail for Epi-lipoxin
    that, like other members of the specialized pro-resolving mediators class of autocoids, form during and act to resolve inflammatory responses. Synthesis...
    3 KB (398 words) - 20:47, 28 October 2024
  • Thumbnail for 5-lipoxygenase-activating protein
    5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein...
    14 KB (1,738 words) - 16:46, 23 May 2025
  • Thumbnail for Inflammation
    anti-inflammatory specialized proresolving mediators, i.e. lipoxins, resolvins, maresins, and neuroprotectins Downregulation of pro-inflammatory molecules...
    96 KB (9,758 words) - 06:03, 28 June 2025
  • docosanoids resolvin D1, resolvin D2, and 17R-resolvin D1 (see specialized pro-resolving mediators; oligopeptides such as N-Formylmethionine-leucyl-phenylalanine;...
    24 KB (2,893 words) - 07:17, 15 May 2024
  • Thumbnail for COTL1
    which act block inflammation and allergic reactions, the specialized pro-resolving mediators of the lipoxin and resolvin subclasses. Based on in vitro...
    8 KB (991 words) - 21:36, 28 December 2023
  • the E,E,Z configuration. PDX and PD1 both possess potent specialized pro-resolving mediator (SPM) anti-inflammatory activity, but only PDX inhibits human...
    8 KB (872 words) - 01:33, 18 December 2024
  • Thumbnail for Formyl peptide receptor 2
    FPR1 or FPR2. A major function of FPR2 is to bind certain specialized pro-resolving mediators (SPMs)—including lipoxin (Lx)A4, AT-LxA4 (arachidonic acid...
    33 KB (4,108 words) - 08:18, 30 June 2025
  • most commonly as PD1 or NPD1 is a member of the class of specialized proresolving mediators. Like other members of this class of polyunsaturated fatty...
    24 KB (2,846 words) - 21:34, 24 September 2024
  • Thumbnail for 2024 Syrian opposition offensives
    the collapse of pro-government forces. The next day, opposition forces made rapid advances, capturing dozens of towns and villages as pro-government forces...
    122 KB (10,369 words) - 00:36, 3 July 2025
  • Thumbnail for TRPV4
    docosahexaenoic acid, is a member of the specialized proresolving mediators (SPMs) class of metabolites that function to resolve diverse inflammatory reactions...
    13 KB (1,475 words) - 00:39, 17 July 2024
  • Thumbnail for CMKLR1
    eicosapentaenoic acid-derived specialized pro-resolving molecule, resolvin E1 (see Specialized proresolving mediators#EPA-derived resolvins (i.e. RvE))...
    11 KB (1,262 words) - 13:44, 15 January 2024
  • is discharged with resolving domestic relations and juvenile cases. The orphans' court is responsible for processing and resolving disputes of, trusts...
    19 KB (1,945 words) - 21:30, 25 September 2024
  • sector whistleblowing plays an important role in the democratic process by resolving principal–agent problems. However, sometimes employees may blow the whistle...
    120 KB (13,230 words) - 03:35, 30 June 2025
  • Thumbnail for TRPV3
    metabolites are members of the specialized proresolving mediators (SPMs) class of metabolites that function to resolve diverse inflammatory reactions...
    12 KB (1,448 words) - 03:35, 23 December 2024