The tumor microenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells...

essential to maintain self-tolerance. In a tumor, however, Tregs form an immunosuppressive microenvironment. Tumor cells produce special cytokines (such as...

Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved...

and their interactions all contribute to the changing tumor microenvironment, which the tumor largely manipulates to be immunotolerant so as to avoid...

reaching the tumor. Tumor associated macrophages, neutrophils and regulatory T-cells secrete cytokines and work to create a tumor microenvironment that promotes...

tumor cells. See the Natural killer cell page for further information on NK cells in tumor surveillance. ILC1s influence the tumor microenvironment by...

enumeration and characterization of the tumor microenvironment in diverse cancer types and across thousands of tumors, an approach largely led by Ash Alizadeh...

company. It develops oncology therapies designed to target the tumor microenvironment. The company was founded in 1998 and went public in 2004. Halozyme...

site of many tumors. Studies in both humans and animal models have implicated that high numbers of Treg cells in the tumor microenvironment is indicative...

cancer cells by influencing the tumor microenvironment. Oncogenes build up an inflammatory pro-tumorigenic microenvironment. Hormones also play a role in...

mimicking the tumor microenvironment. Alternatively, a single-cell suspension enables scientists to collect an unbiased sampling of the whole tumor, eliminating...

changes that occur in cells that make up the tumor microenvironment (TME) and accompany oncogenesis and tumor progression toward a neoplastic state. Cells...

Sciences. He is one of the scientists who laid the foundations of the tumor microenvironment (TME) research field. Isaac Witz was born in Vienna. In September...

contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts...

downregulated. Tumor-associated macrophages (TAMs) have been shown to be abundantly present in the microenvironments of metastasizing tumors. Studies have...

and T lymphocytes. In the tumor microenvironment CD200R is expressed on tumor-associated myeloid cells, particularly in tumor-associate macrophages, myeloid-derived...

regarded as a pioneer in the area of tumor microenvironment and widely recognized for his seminal discoveries in tumor biology, drug delivery, in vivo imaging...

Controllability in Phenotypically Characterized Osteosarcoma: Role of Tumor Microenvironment". Frontiers in Immunology. 8: 918. doi:10.3389/fimmu.2017.00918...

vasculature in the tumor microenvironment) and colonize tumors. This property tends to increase their residence time in the tumor, giving them longer...

environmental factors and molecular changes in the local microenvironment on neoplastic evolution from tumor initiation to patient death. In the colon, a field...

Institute. Her research investigates pancreatic cancer and the tumor microenvironment. Cukierman was born in Mexico City. She emigrated to Israel in 1986...

(July 2017). "Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment". Cancer Cell...

neoplastic transformation. Recent studies have characterized the tumor microenvironment of acinic cell carcinoma, revealing several notable features: Low...

selective advantage during certain stages of tumour progression. The tumor microenvironment may also contribute to tumour expansion, as it is capable of altering...

proteomic analysis toward a better understanding of how tumor cells manipulate their microenvironment by producing structural proteins of ECM, modifying proteins...

fewer side effects. Metronomic therapy is shown to affect both tumor microenvironment and tumor cells to achieve its therapeutic effects. Metronomic therapy...

level of MDSC infiltrate in the tumor microenvironment correlates with shorter survival times of patients with solid tumors and could mediate resistance...

tumors, which adds difficulty to the identification of a target for all tumor cells. 2) Achieving full function of T cells and tumor microenvironment...

cancer development for example through production of IL-17 in the tumor microenvironment, which promotes angiogenesis and cell growth or because their ability...

fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling...