• Thumbnail for NMDA receptor
    receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is...
    109 KB (12,198 words) - 23:08, 22 May 2025
  • Thumbnail for NMDA receptor antagonist
    NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor (NMDAR). They are...
    38 KB (4,198 words) - 21:41, 29 May 2025
  • Thumbnail for Anti-NMDA receptor encephalitis
    Anti-NMDA receptor encephalitis is a type of brain inflammation caused by antibodies. Early symptoms may include fever, headache, and feeling tired. This...
    37 KB (3,815 words) - 23:12, 2 June 2025
  • Thumbnail for GRIN2B
    GRIN2B (redirect from NMDA receptor 2B)
    Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is...
    16 KB (1,905 words) - 14:50, 13 August 2024
  • Thumbnail for N-Methyl-D-aspartic acid
    acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as those...
    12 KB (986 words) - 21:39, 23 May 2025
  • Thumbnail for Olney's lesions
    Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not...
    14 KB (1,854 words) - 06:27, 26 May 2025
  • Thumbnail for Ketamine
    Ketamine (category NMDA receptor antagonists)
    Ketamine is a cyclohexanone-derived general anesthetic and NMDA receptor antagonist with analgesic and hallucinogenic properties, used medically for anesthesia...
    119 KB (11,494 words) - 20:54, 2 June 2025
  • Extrasynaptic NMDA receptors are glutamate-gated neurotransmitter receptors that are localized to non-synaptic sites on the neuronal cell surface. In...
    6 KB (630 words) - 14:34, 22 November 2022
  • Thumbnail for Phencyclidine
    member of the arylcyclohexylamine class. PCP works primarily as an NMDA receptor antagonist. PCP is most commonly used in the US. While usage peaked...
    57 KB (5,444 words) - 02:58, 17 May 2025
  • NMDA receptor modulators (glutamate modulators) are a new form of antipsychotic that are in Phase II FDA studies. The first compound studied was glycine...
    5 KB (525 words) - 01:49, 27 May 2025
  • Thumbnail for Ligand-gated ion channel
    acid receptor (also known as AMPA receptor, or quisqualate receptor) is a non-NMDA-type ionotropic transmembrane receptor for glutamate that...
    29 KB (2,607 words) - 05:16, 26 May 2025
  • Thumbnail for Glutamate receptor
    glutamate receptors, such as NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), and kainate receptors, have distinct...
    64 KB (7,009 words) - 16:40, 27 May 2025
  • Thumbnail for Brain-derived neurotrophic factor
    to NMDA receptor activation, triggering a calcium influx. Through a protein signaling cascade requiring Erk, CaM KII/IV, PI3K, and PLC, NMDA receptor activation...
    50 KB (5,881 words) - 13:31, 5 May 2025
  • Thumbnail for Kainate receptor
    non-NMDA-type receptor, along with the AMPA receptor. KARs are less understood than AMPA and NMDA receptors, the other ionotropic glutamate receptors. Postsynaptic...
    11 KB (1,271 words) - 12:11, 25 May 2025
  • Thumbnail for Metabotropic glutamate receptor
    effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740...
    35 KB (3,654 words) - 02:43, 28 May 2025
  • Thumbnail for Excitotoxicity
    in excessive stimulation of receptors. For example, when glutamate receptors such as the NMDA receptor or AMPA receptor encounter excessive levels of...
    25 KB (2,821 words) - 14:45, 6 April 2025
  • Thumbnail for Agonist
    Agonist (redirect from Receptor agonist)
    acetylcholine receptor and NMDA receptor and their respective agonists. For the muscarinic acetylcholine receptor, which is a G protein-coupled receptor(GPCR)...
    14 KB (1,626 words) - 18:44, 3 April 2025
  • Thumbnail for Long-term potentiation
    Theory, which depends also on intracellular calcium in relation to NMDA receptor voltage gates, have been developed since the 1980s and modify the traditional...
    64 KB (7,638 words) - 12:12, 24 May 2025
  • NMDA receptors become the control mechanism that dictates how the AMPA and NMDA receptors are to be rearranged. The rearrangement of AMPA and NMDA receptors...
    26 KB (3,823 words) - 11:52, 16 January 2024
  • Thumbnail for Antidepressant
    antidepressants and seem to work via blockade of the ionotropic glutamate NMDA receptor. Other NMDA antagonists may also play a role in treating depression. The combination...
    198 KB (21,019 words) - 03:15, 2 June 2025
  • Thumbnail for AMPA receptor
    from NMDA receptors (the other main ionotropic glutamate receptors in the brain), which also permit calcium influx. Both AMPA and NMDA receptors, however...
    75 KB (8,581 words) - 18:06, 23 May 2025
  • Thumbnail for Susannah Cahalan
    Madness, about her hospitalization with a rare autoimmune disease, anti-NMDA receptor encephalitis. She published a second book, The Great Pretender: The...
    13 KB (1,322 words) - 17:05, 8 May 2025
  • Thumbnail for Memantine
    Memantine (category NMDA receptor antagonists)
    psychosis, and heart failure. It is believed to work by acting on NMDA receptors, working as a pore blocker of these ion channels. Memantine was first...
    67 KB (6,305 words) - 03:20, 2 June 2025
  • non-competitive NMDA receptor antagonist, other actions Gepirone (Exxua) – 5-HT1A receptor partial agonist and α2-adrenergic receptor antagonist Opipramol...
    18 KB (1,537 words) - 20:49, 7 May 2025
  • Thumbnail for Ionotropic glutamate receptor
    and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors (see below). AMPA receptors are the main charge carriers...
    5 KB (433 words) - 06:16, 15 October 2023
  • Thumbnail for High-frequency oscillations
    other NMDA receptor blockers). There are increasing number of studies indicating that HFO rhythms (130–180 Hz) may arise due to the local NMDA receptor blockage...
    23 KB (2,457 words) - 05:35, 23 May 2025
  • Thumbnail for Lithium (medication)
    NMDA receptor blockage augments antidepressant-like effects of lithium in the mouse forced swimming test, indicating the possible involvement of NMDA...
    105 KB (11,203 words) - 14:13, 23 May 2025
  • diazepam), and barbiturates (sodium thiopental, methohexital). Ketamine, an NMDA receptor antagonist, is used primarily for its analgesic effects and in an off-label...
    23 KB (2,717 words) - 06:53, 10 May 2025
  • Thumbnail for Dizocilpine
    Dizocilpine (category NMDA receptor antagonists)
    Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the...
    29 KB (3,416 words) - 05:01, 25 May 2025
  • Thumbnail for Cell surface receptor
    neurotrophin receptors Ephrin receptors Integrins Low Affinity Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll-like receptor T cell...
    22 KB (2,480 words) - 14:02, 24 March 2025