Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the...
31 KB (4,194 words) - 08:16, 24 June 2025
condensation in late anaphase, to help chromosome segregation and the re-formation of the nucleus. Anaphase starts when the anaphase promoting complex marks an inhibitory...
6 KB (719 words) - 02:00, 2 May 2024
Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin–Cdk complex that was discovered...
6 KB (877 words) - 05:26, 24 March 2025
of this checkpoint is the stimulation of the anaphase-promoting complex by M-phase cyclin-CDK complexes, which in turn causes the proteolytic destruction...
73 KB (9,173 words) - 03:18, 3 July 2025
Cell division (section Anaphase)
triggers the abrupt shift to anaphase. This abrupt shift is caused by the activation of the anaphase-promoting complex and its function of tagging degradation...
41 KB (4,776 words) - 23:11, 21 July 2025
with the anaphase-promoting complex, SCF has important roles in the ubiquitination of proteins involved in the cell cycle. The SCF complex also marks...
16 KB (2,027 words) - 14:47, 2 July 2025
activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20...
26 KB (3,307 words) - 05:21, 19 July 2025
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene. A large protein complex, termed the anaphase-promoting...
8 KB (1,065 words) - 21:22, 15 July 2025
Meiosis (redirect from Anaphase I)
facilitated by the anaphase-promoting complex (APC). CDK1 is regulated by cyclin B, whose synthesis peaks at the end of meiosis I. At anaphase I, cyclin B is...
76 KB (8,984 words) - 18:03, 23 July 2025
Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene. ANAPC11 has been shown to interact with ANAPC2 and CDC27...
5 KB (656 words) - 05:05, 19 July 2025
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. The anaphase-promoting complex (APC) consists of at least...
8 KB (950 words) - 15:38, 17 July 2025
Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene. ANAPC10 has been shown to interact with CDC27, Mothers...
6 KB (803 words) - 05:05, 19 July 2025
progression to anaphase. Any unattached or improperly attached kinetochores generate signals that prevent the activation of the anaphase promoting complex (cyclosome...
6 KB (555 words) - 15:14, 10 July 2025
anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667. "Entrez Gene: ANAPC1 anaphase promoting complex...
6 KB (764 words) - 03:51, 15 July 2025
Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene. A large protein complex, termed the anaphase-promoting...
6 KB (795 words) - 21:22, 15 July 2025
assembly checkpoint inhibits the anaphase promoting complex. Normally, activation of the anaphase promoting complex leads to the separation of sister...
30 KB (3,020 words) - 08:11, 18 July 2025
Mad2 (section Metaphase-to-anaphase transition)
cohesin complex which links the sister chromatids together. Without Cdc20, the anaphase-promoting complex (APC) cannot become activated and anaphase is not...
10 KB (1,150 words) - 01:00, 17 April 2025
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms...
7 KB (908 words) - 05:05, 19 July 2025
(cdc20 homolog 1) is one of the substrate adaptor proteins of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning...
14 KB (1,553 words) - 03:55, 26 August 2024
The anaphase- promoting complex or cyclosome (APC/C) is a highly specific ubiquitin protein ligase responsible for triggering events of late mitosis....
5 KB (750 words) - 18:09, 7 November 2023
encoded by the APC gene, mutations in which can cause colon cancer Anaphase-promoting complex, a ubiquitin ligase cell cycle protein Antigen-presenting cell...
7 KB (828 words) - 00:52, 29 May 2025
S-phase and is degraded at the metaphase-anaphase transition, possibly through ubiquination by anaphase promoting complex (APC). Various cell cycle checkpoints...
121 KB (14,916 words) - 04:06, 3 January 2025
cyclin. Cyclins are targeted for proteolytic degradation by the anaphase promoting complex (APC), also known as the cyclosome, a ubiquitin-ligase. The active...
23 KB (2,682 words) - 22:30, 15 July 2025
transcription factors downregulate expression of S phase cyclin genes; anaphase-promoting complex (APC) is activated, which targets and degrades S and M cyclins...
10 KB (1,235 words) - 09:37, 30 June 2025
(or APC2), part of the Anaphase-promoting complex. CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin...
7 KB (718 words) - 21:57, 20 September 2023
Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. 15 (21)...
9 KB (1,059 words) - 18:21, 17 July 2025
releases its inhibition of the anaphase promoting complex (APC), which in turn irreversibly triggers progression through anaphase.[citation needed] Surveys...
25 KB (2,903 words) - 22:03, 15 July 2025
regulator which ensures timely mitotic entry by primarily inhibiting Anaphase-Promoting Complex/Cyclosome (APC/C) activity. This protein is present in many organisms...
18 KB (2,170 words) - 04:49, 2 June 2025
signal. This prevents premature progression into anaphase by inhibiting the anaphase-promoting complex until all kinetochores are attached and all the...
4 KB (337 words) - 20:04, 25 May 2025
sensed, which initiates the anaphase entry. To do this, the sensing mechanism ensures that the anaphase-promoting complex (APC/C) is no longer inhibited...
34 KB (4,587 words) - 15:21, 9 December 2024