• Thumbnail for Bilirubin glucuronide
    Bilirubin glucuronide is a water-soluble reaction intermediate over the process of conjugation of indirect bilirubin. Bilirubin glucuronide itself belongs...
    30 KB (2,694 words) - 12:35, 16 July 2024
  • Thumbnail for Bilirubin
    first to bilirubin glucuronide and then to bilirubin diglucuronide, making it soluble in water: the conjugated version is the main form of bilirubin present...
    50 KB (5,123 words) - 19:04, 14 May 2025
  • condition describing an elevation of blood bilirubin level due to the inability to properly metabolise or excrete bilirubin, a product of erythrocytes breakdown...
    34 KB (3,363 words) - 08:17, 25 October 2024
  • Thumbnail for Urine test strip
    with colouration that varies from pink to violet: In acid medium Bilirubin glucuronide + Diazonium salt→ Azo dye (violet) False positive reactions can...
    54 KB (6,376 words) - 19:10, 31 March 2025
  • Thumbnail for Glucuronic acid
    baby syndrome. Bilirubin is excreted in the bile as bilirubin diglucuronide (80%), bilirubin glucuronide (20%), and unconjugated bilirubin (< 1%). In the...
    19 KB (2,065 words) - 07:23, 16 January 2025
  • Thumbnail for Bilirubin diglucuronide
    Bilirubin di-glucuronide is a conjugated form of bilirubin formed in bilirubin metabolism. The hydrophilic character of bilirubin diglucuronide enables...
    4 KB (135 words) - 12:35, 16 July 2024
  • Thumbnail for Dubin–Johnson syndrome
    conjugates from hepatocytes into bile. Impaired biliary excretion of bilirubin glucuronides is due to a mutation in the canalicular multiple drug-resistance...
    9 KB (855 words) - 12:05, 14 October 2024
  • Thumbnail for Neonatal jaundice
    of the white part of the eyes and skin in a newborn baby due to high bilirubin levels. Other symptoms may include excess sleepiness or poor feeding....
    31 KB (3,308 words) - 23:42, 5 May 2025
  • Thumbnail for Gallstone
    hepatocytes and bacteria) which hydrolyzes bilirubin glucuronides and increases the amount of unconjugated bilirubin in bile. Between 4% and 20% of stones...
    52 KB (4,879 words) - 22:20, 5 May 2025
  • Thumbnail for Glucuronosyltransferase
    namely, excessive bilirubin synthesis, liver bilirubin uptake malfunction, and bilirubin conjugation compromise. As to excessive bilirubin synthesis, both...
    7 KB (685 words) - 12:33, 28 March 2025
  • Thumbnail for Stercobilin
    residues into bilirubin diglucuronide, and secreted into the small intestine as bile. In the small intestine, some bilirubin glucuronide is converted back...
    7 KB (613 words) - 00:27, 4 January 2025
  • involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid...
    7 KB (544 words) - 13:50, 5 June 2024
  • Thumbnail for Cholestasis
    inhibition, MRP2 is an apical efflux transporter that mainly exports bilirubin glucuronide and glutathione into bile. However, MRP2 is also the preferential...
    113 KB (12,756 words) - 17:31, 29 April 2025
  • Thumbnail for Β-Glucuronidase
    lysosome. In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present...
    24 KB (2,644 words) - 18:43, 11 December 2023
  • Thumbnail for Heme
    deconjugate bilirubin diglucuronide releasing free bilirubin, which can either be reabsorbed or reduced to urobilinogen by the bacterial enzyme bilirubin reductase...
    42 KB (4,397 words) - 02:54, 22 March 2025
  • Thumbnail for Lorazepam
    conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine. Lorazepam glucuronide has no demonstrable CNS activity in animals...
    84 KB (8,688 words) - 18:32, 10 May 2025
  • Thumbnail for UGT1A6
    pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This...
    9 KB (1,071 words) - 02:16, 7 June 2024
  • Thumbnail for Recurrent pyogenic cholangitis
    Escherichia coli in bile. In humans, the majority of bilirubin is excreted in the bile as bilirubin glucuronide.[citation needed] Hepatolithiasis is associated...
    10 KB (999 words) - 00:25, 24 November 2022
  • Thumbnail for Irinotecan
    activity, may lead to severe toxicity. Also, UGT1A1 conjugates bilirubin and bilirubin glucuronidation is another risk factor for increased toxicity The...
    26 KB (2,315 words) - 16:07, 12 January 2025
  • Thumbnail for Anabolic steroid
    (ASTTooltip aspartate aminotransferase, ALTTooltip alanine aminotransferase, bilirubin, LDHTooltip lactic dehydrogenase, ALPTooltip alkaline phosphatase), hepatotoxicity...
    209 KB (21,562 words) - 00:16, 20 May 2025
  • Thumbnail for Solute carrier organic anion transporter family member 1B3
    Docetaxel [D-penicillamine2,5]enkephalin (DPDPE) Enalapril Estradiol-17β-glucuronide 5–25 Estrone-3-sulfate Fexofenadine Fluvastatin Fluo-3 Glutathione (GSH)...
    9 KB (1,071 words) - 04:42, 17 June 2024
  • Thumbnail for Paracetamol poisoning
    metabolites via Phase II metabolism by conjugation with sulfate and glucuronide, with a small portion being oxidized via the cytochrome P450 enzyme system...
    65 KB (7,284 words) - 06:13, 3 April 2025
  • Thumbnail for Artemisinin
    during the first few weeks of life as it interferes with the action of bilirubin and can worsen neonatal jaundice. In HIV-positive people, the combination...
    59 KB (6,414 words) - 19:51, 8 May 2025
  • blood 5-5.7 ×10−4 Bile acids Digestive function, bilirubin excretion 2-30 ×10−6 3-30 ×10−6 Bilirubin Hemoglobin metabolite 2-14 ×10−6 1-10 ×10−6 Biotin...
    26 KB (94 words) - 15:48, 20 March 2023
  • 189: uteolin 7-O-glucuronosyltransferase EC 2.4.1.190: luteolin-7-O-glucuronide 2′′-O-glucuronosyltransferase EC 2.4.1.191: luteolin-7-O-diglucuronide...
    215 KB (21,664 words) - 05:19, 27 April 2025
  • hydrophilic estrogen conjugates such as estrone sulfate and estradiol glucuronide, which require active transport via specific membrane transport proteins...
    103 KB (12,043 words) - 12:59, 2 November 2024
  • Thumbnail for Amoxapine
    product of haem breakdown, bilirubin, most often the result of liver damage as it is the liver's responsibility to clear bilirubin. It tends to produce less...
    32 KB (2,715 words) - 20:24, 10 May 2025
  • Thumbnail for Polyestradiol phosphate
    cholestatic jaundice, cholelithiasis, transient increases in transaminases and bilirubin, erythema multiforme, hyperpigmentation, muscle cramps, dysmenorrhea,...
    77 KB (7,710 words) - 10:02, 15 December 2024
  • Thumbnail for Estramustine phosphate
    (liver) Bilirubin alone 1 5 Bilirubin and LDHTooltip lactate dehydrogenase 0 1 Bilirubin and ASTTooltip aspartate transaminase 2 1 Bilirubin, LDH, and...
    69 KB (6,652 words) - 08:35, 17 April 2025