• Thumbnail for C-fos-induced growth factor
    C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded...
    10 KB (1,256 words) - 05:23, 19 July 2025
  • Thumbnail for Protein c-Fos
    bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes...
    26 KB (3,991 words) - 05:29, 10 July 2024
  • Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They...
    48 KB (4,885 words) - 00:05, 18 July 2025
  • Thumbnail for AP-1 transcription factor
    proteins belonging to the c-Fos, c-Jun, ATF and JDP families. AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory...
    42 KB (4,614 words) - 19:07, 4 August 2025
  • Thumbnail for Transcription factor Jun
    Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response...
    46 KB (5,537 words) - 04:52, 15 July 2025
  • Thumbnail for Methamphetamine
    amphetamine induces a unique transcription factor delta FosB, which plays an essential role in long-term adaptive changes in the brain. Cadet JL, Brannock C, Jayanthi...
    170 KB (16,595 words) - 10:50, 5 August 2025
  • Thumbnail for Adderall
    amphetamine induces a unique transcription factor delta FosB, which plays an essential role in long-term adaptive changes in the brain. Cadet JL, Brannock C, Jayanthi...
    63 KB (23,111 words) - 23:58, 4 August 2025
  • Thumbnail for FOSB
    FOSB (redirect from FosB)
    proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as...
    57 KB (7,191 words) - 16:36, 17 July 2025
  • Thumbnail for Dextroamphetamine
    amphetamine induces a unique transcription factor delta FosB, which plays an essential role in long-term adaptive changes in the brain. Cadet JL, Brannock C, Jayanthi...
    66 KB (22,224 words) - 05:36, 19 July 2025
  • Thumbnail for NF-κB
    words, c-Fos repression allows ΔFosB to accumulate within nucleus accumbens medium spiny neurons more rapidly because it is selectively induced in this...
    90 KB (9,842 words) - 21:54, 10 July 2025
  • Thumbnail for EGR1
    EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1...
    14 KB (1,524 words) - 03:17, 3 August 2025
  • Thumbnail for CREB
    CREB (category Transcription factors)
    1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, BDNF, tyrosine...
    19 KB (2,243 words) - 23:46, 9 September 2024
  • Thumbnail for Amphetamine
    synaptic terminals. ... Chronic exposure to amphetamine induces a unique transcription factor delta FosB, which plays an essential role in long-term adaptive...
    324 KB (34,743 words) - 00:24, 1 August 2025
  • Thumbnail for HIF1A
    Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that...
    65 KB (7,427 words) - 10:18, 18 July 2025
  • Thumbnail for Transcription factor Sp1
    2001). "Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial...
    30 KB (3,441 words) - 08:44, 5 February 2025
  • Thumbnail for Oncogene
    regulator properties include: Growth factors are usually secreted by either specialized or non-specialized cells to induce cell proliferation in themselves...
    28 KB (3,143 words) - 03:54, 25 June 2025
  • also regulates the transcription of the C-Fos gene. By altering the levels and activities of transcription factors, MAPK leads to altered transcription of...
    24 KB (3,066 words) - 14:18, 3 June 2025
  • Thumbnail for Hypothalamus
    that controls motivated behaviors, like defensive behaviors. Analyses of Fos-labeling showed that a series of nuclei in the "behavioral control column"...
    50 KB (4,994 words) - 04:59, 2 August 2025
  • Thumbnail for EGR2
    Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing...
    19 KB (2,074 words) - 10:21, 18 July 2025
  • c-fos, c-myc and c-jun, genes that were found to be homologous to retroviral oncogenes. Thus IEGs are well known as early regulators of cell growth and...
    17 KB (1,965 words) - 00:08, 27 October 2024
  • Thumbnail for ATF4
    T, Curran T (May 1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity". Proceedings of the...
    15 KB (1,773 words) - 03:53, 15 July 2025
  • Thumbnail for Nuclear receptor 4A1
    NR4A1 has homologous genes in a range of species including neuronal growth factor-induced clone B in rats, Nur77 in mice and TR3 in humans. Along with 16...
    21 KB (2,532 words) - 22:04, 15 July 2025
  • Thumbnail for RUNX2
    (January 2002). "Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation". The Journal...
    19 KB (2,246 words) - 09:06, 24 June 2025
  • Thumbnail for Sex-determining region Y protein
    very similar to SRY's. SOX9 leads to the upregulation of fibroblast growth factor 9 (Fgf9), which in turn leads to further upregulation of SOX9. Once...
    42 KB (5,211 words) - 15:51, 5 August 2025
  • Thumbnail for Endometriosis
    Activation of both of the MAP and ERK pathways lead to increased levels of c-Fos and c-Jun, which are proto-oncogenes that are associated with high-grade lesions...
    164 KB (16,760 words) - 16:50, 1 August 2025
  • Thumbnail for KIT (gene)
    kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction". Oncogene. 18 (40): 5546–5553...
    35 KB (4,121 words) - 06:16, 19 July 2025
  • Thumbnail for USF1
    transcription factor (AP-1) refers to a complex of dimeric transcription factors composed of c-Jun, c-Fos, or activating transcription factor (ATF) that...
    41 KB (4,563 words) - 09:19, 18 July 2025
  • Thumbnail for Mothers against decapentaplegic homolog 2
    Mothers against decapentaplegic homolog 2 (category Transcription factors)
    Transforming Growth Factor β Signals". Mol. Cell. Biol. 19 (1): 424–30. doi:10.1128/MCB.19.1.424. ISSN 0270-7306. PMC 83900. PMID 9858566. Liu F, Pouponnot C, Massagué...
    16 KB (1,925 words) - 17:29, 17 July 2025
  • Thumbnail for CXCL1
    melanoma growth stimulating activity, alpha (MGSA-α). CXCL1 was first cloned from a cDNA library of genes induced by platelet-derived growth factor (PDGF)...
    14 KB (1,728 words) - 16:03, 28 October 2024
  • Thumbnail for STAT protein
    DNA-binding domains, respectively. Extracellular binding of cytokines or growth factors induce activation of receptor-associated Janus kinases, which phosphorylate...
    6 KB (514 words) - 10:42, 22 May 2025