subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. It has necessary roles in the formation and stability of microtubules...
11 KB (1,236 words) - 18:42, 22 August 2021
when mutated. In addition to microcephalin, these include WDR62 (MCPH2), CDK5RAP2 (MCPH3), KNL1 (MCPH4), ASPM (MCPH5), CENPJ (MCPH6), STIL (MCPH7), CEP135...
46 KB (4,286 words) - 05:04, 10 March 2025
within both the MCPH1 gene and another similarly studied microcephaly gene, CDK5RAP2. Microcephalin proteins contain the following three domains: N-terminal...
18 KB (1,808 words) - 02:59, 19 December 2023
TUBE1, Tubulin epsilon chain PCNT, pericentrin, a matrix scaffold protein CDK5RAP2, cyclin dependant kinase receptor associated protein 2, binds gTubRCs that...
3 KB (341 words) - 17:13, 12 February 2023
structure): Centrosomes XMAP215 EB1 CLASP APC LIS1 FOP Dynein Dynactin CDK5RAP2 Microtubules Ncd Klp2 Endoplasmic Reticulum EB1 STIM1 F-actin MACF APC...
8 KB (875 words) - 07:52, 27 May 2024
Corry P, Walsh CA, Woods CG (Apr 2005). "A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size". Nature Genetics. 37 (4): 353–5. doi:10...
9 KB (1,182 words) - 02:38, 19 December 2023
locus notation FIP1L1 4q12 t(4;4)(q12;q12) KIF5B 10p11 t(4;11)(q12;p11) CDK5RAP2 9q33 t(5;9)(q12;q33) STRN 2p24 t(2;4)(q24-p12) ETV6 12p13.2 (4;12)(q2?3;p1...
29 KB (3,358 words) - 23:42, 16 March 2025
isoform, is a paralogue of CDK5RAP2. Myomegalin depletion in cells does not lead to decreases in γ-tubulin or CDK5RAP2, unlike CDK5RAP2 depletion, and does not...
9 KB (989 words) - 00:49, 3 January 2024
NBPF genes via duplication. Myomegalin itself arose from a duplication of CDK5RAP2, and all of these genes have been implicated in the development of neurons...
38 KB (4,550 words) - 00:34, 1 February 2025
rootletin". Graser S, Stierhof YD, Nigg EA (December 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". J. Cell Sci. 120 (Pt 24): 4321–31...
5 KB (638 words) - 00:19, 3 December 2024
Q15078 2660 CDK5R2 HGNC:1776 Q13319 2661 CDK5RAP1 HGNC:15880 Q96SZ6 2662 CDK5RAP2 HGNC:18672 Q96SN8 2663 CDK5RAP3 HGNC:18673 Q96JB5 2664 CDK6 HGNC:1777 Q00534...
277 KB (17 words) - 18:34, 6 October 2024
Chromosome translocations between the PDGFRA gene and either the FIP1L1, KIF5B, CDK5RAP2, STRN, ETV6, FOXP1, TNKS2, BCR or JAK2 gene create a fusion gene which...
48 KB (5,760 words) - 10:46, 16 November 2024
2; 251200; MCPH2 Microcephaly, primary autosomal recessive, 3; 604804; CDK5RAP2 Microcephaly, primary autosomal recessive, 4; 251200; MCPH4 Microcephaly...
234 KB (18,877 words) - 18:07, 24 March 2025
in patients with primary autosomal recessive microcephaly and a novel CDK5RAP2 mutation". Orphanet Journal of Rare Diseases. 8 (1): 59. doi:10.1186/1750-1172-8-59...
15 KB (1,881 words) - 20:06, 3 December 2023
68kDa". Graser S, Stierhof YD, Nigg EA (Dec 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt...
4 KB (500 words) - 09:54, 8 March 2025
alpha 1 Amphiphysin, Beta-catenin, CAMK2A, CDK5RAP2, Cyclin-dependent kinase 5, Protein SET, CDK5RAP1 CDK5RAP2 CDK5RAP3 GRCh38: Ensembl release 89: ENSG00000176749...
11 KB (1,381 words) - 16:05, 13 October 2024
the positive selection is generally the next step. For example, ASPM, CDK5RAP2 and NIN are genes that are positively selected for on the human lineage...
80 KB (9,520 words) - 22:29, 11 July 2024