• Thumbnail for Coactivator (genetics)
    A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a...
    18 KB (1,698 words) - 10:42, 3 December 2023
  • Thumbnail for Mediator (coactivator)
    Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg...
    31 KB (3,502 words) - 04:27, 19 February 2024
  • Thumbnail for PPARGC1A
    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is...
    28 KB (3,324 words) - 06:25, 3 June 2024
  • Thumbnail for Nuclear receptor coactivator 3
    The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified...
    21 KB (2,383 words) - 15:17, 11 October 2023
  • Thumbnail for Pparg coactivator 1 alpha
    PPARG coactivator 1 alpha is a protein that in humans is encoded by the PPARGC1A gene. The protein encoded by this gene is a transcriptional coactivator that...
    5 KB (637 words) - 08:17, 11 March 2024
  • Thumbnail for Nuclear receptor coactivator 1
    The nuclear receptor coactivator 1 (NCOA1), also called steroid receptor coactivator-1 (SRC-1), is a transcriptional coregulatory protein that contains...
    15 KB (1,699 words) - 20:28, 22 November 2023
  • CREB regulated transcription coactivator (CRTC) may refer to the following proteins and genes: CRTC1 CRTC2 CRTC3 CREB CRTC (disambiguation) This disambiguation...
    207 bytes (53 words) - 04:06, 28 December 2019
  • Thumbnail for FRY like transcription coactivator
    FRY like transcription coactivator is a protein that in humans is encoded by the FRYL gene. GRCh38: Ensembl release 89: ENSG00000075539 – Ensembl, May...
    467 bytes (73 words) - 07:27, 1 January 2023
  • Thumbnail for PPARGC1B
    Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene. PPARGC1A Peroxisome...
    8 KB (1,007 words) - 22:46, 3 March 2023
  • Thumbnail for Nuclear receptor coactivator 2
    The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid...
    19 KB (2,166 words) - 15:30, 5 March 2024
  • Thumbnail for P300-CBP coactivator family
    The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called...
    18 KB (2,107 words) - 07:43, 4 May 2024
  • Thumbnail for Peroxisome proliferator-activated receptor gamma
    peroxisome proliferator-activated receptor gamma with transcriptional coactivators". The Journal of Biological Chemistry. 275 (43): 33201–4. doi:10.1074/jbc...
    20 KB (2,137 words) - 06:53, 4 January 2024
  • Thumbnail for Androgen receptor
    agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) A ligand dependent...
    87 KB (9,673 words) - 02:09, 31 May 2024
  • Thumbnail for Exercise mimetic
    peroxisome proliferator-activated receptor delta GW501516 PPAR gamma coactivator 1-alpha estrogen-related receptor γ GSK4716 NFE2L2 Canonical transient...
    4 KB (392 words) - 20:53, 2 January 2024
  • Thumbnail for Selective estrogen receptor modulator
    interact with a number of coactivators. Coactivators are not just protein partners that connect sites together in a complex. Coactivators play an active role...
    56 KB (6,397 words) - 06:15, 13 January 2024
  • Thumbnail for NCOA5
    Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5...
    4 KB (560 words) - 01:57, 5 October 2022
  • Thumbnail for CREB-binding protein
    or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3....
    52 KB (5,272 words) - 09:56, 3 June 2024
  • Thumbnail for Nuclear receptor
    to the dimerization interface of the receptor and in addition, binds coactivator and corepressor proteins. The LBD also contains the activation function...
    74 KB (6,675 words) - 05:46, 31 May 2024
  • Thumbnail for Tretinoin
    microcomedone formation. The retinoid-receptor complex competes for coactivator proteins of AP-1, a key transcription factor involved in inflammation...
    31 KB (2,940 words) - 06:07, 28 February 2024
  • Thumbnail for Amphetamine
    repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...
    258 KB (26,889 words) - 01:30, 13 June 2024
  • Thumbnail for Adderall
    repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...
    57 KB (21,502 words) - 18:17, 11 June 2024
  • variable, in statistics Mediator (coactivator), a multiprotein complex that functions as a transcriptional coactivator Endogenous mediator, proteins that...
    1 KB (208 words) - 21:39, 15 February 2024
  • Thumbnail for Bert W. O'Malley
    previously unidentified coactivators necessary for receptor-dependent gene transcription. In 1995, he successfully cloned the first coactivator, SRC-1, marking...
    19 KB (2,089 words) - 16:37, 23 May 2024
  • Thumbnail for Addiction
    repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...
    266 KB (31,209 words) - 18:05, 30 May 2024
  • Thumbnail for Estrogen receptor alpha
    acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". The EMBO Journal. 20 (6):...
    60 KB (6,357 words) - 21:20, 29 March 2024
  • Thumbnail for NCOA6
    receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene. The protein encoded by this gene is a transcriptional coactivator that can...
    16 KB (1,890 words) - 01:13, 6 May 2024
  • Thumbnail for Dextroamphetamine
    repression, or suppression – decrease the rate of gene transcription coactivator – a protein (or a small molecule) that works with transcription factors...
    59 KB (20,596 words) - 03:32, 11 June 2024
  • Thumbnail for Adipose tissue
    gamma (PPARγ), PRDM16, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), and Early B-Cell Factor-2 (EBF2). The list of molecules...
    73 KB (8,489 words) - 02:45, 11 May 2024
  • Thumbnail for Androgen insensitivity syndrome
    not be corrected by supplementation with any coactivators known at the time, nor was the absent coactivator protein characterized, which left some in the...
    128 KB (12,669 words) - 15:58, 14 June 2024
  • Thumbnail for Histone acetyltransferase
    that exhibit HAT activity. These include p300/CBP, nuclear receptor coactivators (e.g., ACTR/SRC-1), TAFII250, TFIIIC, Rtt109, and CLOCK. p300/CBP are...
    53 KB (6,148 words) - 05:00, 3 December 2023