The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating...

Renin inhibitors are pharmaceutical drugs inhibiting the activity of renin that is responsible for hydrolyzing angiotensinogen to angiotensin I, which...

inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. This class of medicine...

drugs but further research is needed.[citation needed] Discovery and development of renin inhibitors Aulakh GK, Sodhi RK, Singh M; Sodhi; Singh (August 2007)...

enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found...

recommended as a first-line agent in the treatment of hypertension, as thiazides diuretics, ACE inhibitors, and calcium channel blockers show greater benefit...

hypertension. As of 2019, the wider cardiovascular benefits of PDE5 inhibitors are being appreciated. Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil...

and pharmacologist noted for the discovery of the bradykinin potentiating factor, which led to new and widely used anti-hypertension drugs — the ACE inhibitors...

inhibitors (ACE inhibitors) increase bradykinin levels by inhibiting its degradation, thereby increasing its blood pressure lowering effect. ACE inhibitors...

4-Hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors (HPPD inhibitors) are a class of herbicides that prevent growth in plants by blocking 4-Hydroxyphenylpyruvate...

the first JAK inhibitor, ruxolitinib, to treat a skin condition. Some JAK1 inhibitors are based on a benzimidazole core. JAK3 inhibitors target the catalytic...

Moexipril was an angiotensin converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. Moexipril can be...

There are several types of drugs which include ACE inhibitors, angiotensin II receptor blockers (ARBs), and renin inhibitors that interrupt different...

Aliskiren (brand names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. It is used for essential (primary) hypertension...

described; this led to the development of a number of other ACE inhibitors. More recently angiotensin receptor blockers and renin inhibitors have also been introduced...

system inhibitors (RAS inhibitors) or in diseases where circulating angiotensin II is elevated. An in vitro study focused on the early stages of infection...

(EU), there is a label claim for use in cats. Discovery and development of cyclooxygenase 2 inhibitors "non-steroidal anti-inflammatory drug". www.Lexico...

receptors-signalling proteins myostatin and activin A via activin A/myostatin inhibitor ACVR2B – tested preliminarily in humans in the form of ACE-031 in the early 2010s...

oral renin inhibitor. ACE inhibitors or ARBs are also part of the standard treatment after a heart attack. The differential diagnosis of kidney cancer...

vasoconstrictors, vasodilators. HMG-CoA reductase inhibitors (statins) for lowering LDL cholesterol inhibitors: hypolipidaemic agents. Drugs affecting the central...

important and most widely used medications are thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin...

S2CID 37686043. Endo A (November 1992). "The discovery and development of HMG-CoA reductase inhibitors". Journal of Lipid Research. 33 (11): 1569–1582. doi:10...

specificity and generally easily accessible through the vascular system. This has made venoms a subject of study for people who work in drug discovery. With...

cardiac remodeling). This is why ACE inhibitors and ARBs help to prevent remodeling that occurs secondary to angiotensin II and are beneficial in congestive...

Proscar used for the treatment of enlarged prostate and prostate cancer and of the ACE inhibitor Vasotec for treating hypertension. Following his departure...

for receptors and ion channels, enzyme inhibitors, phosphospecific antibodies, key signal transduction enzymes, and assay kits for cell signaling. ISOTEC...

(RAS) and his investigations into gene therapy for vascular disease. His research laid the foundation for the development of ACE inhibitors, a class of drugs...

Camiña M, Laguna R (2012). "History and therapeutic use of MAO-A inhibitors: a historical perspective of MAO-A inhibitors as antidepressant drug". Curr Top...

S2CID 3344720. Endo A (1 November 1992). "The discovery and development of HMG-CoA reductase inhibitors". Journal of Lipid Research. 33 (11): 1569–82. doi:10...

and one in preclinical development. Luspatercept (ACE-536) for anemia Sotatercept (ACE-011) for pulmonary arterial hypertension Dalantercept (ACE-041)...