Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various...
33 KB (3,756 words) - 10:53, 22 April 2025
Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin...
7 KB (821 words) - 09:44, 30 January 2023
drugs from the class of direct Xa inhibitors are marketed worldwide. Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially...
41 KB (4,916 words) - 17:03, 23 September 2024
Hirudin (category Direct thrombin inhibitors)
Several other direct thrombin inhibitors are derived chemically from hirudin. Hirudotherapy Discovery and development of direct thrombin inhibitors PDB: 4HTC...
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antithrombin to thrombin (as well as factor Xa). The direct thrombin inhibitors, a newer class of medication, directly inhibit thrombin by binding to its...
25 KB (2,932 words) - 18:21, 24 May 2025
Ximelagatran (category Direct thrombin inhibitors)
Argentina and Brazil). Ximelagatran, a direct thrombin inhibitor, was the first member of this class that can be taken orally. It acts solely by inhibiting the...
11 KB (972 words) - 19:24, 20 December 2023
Coagulation (redirect from Blood coagulation factor inhibitors)
heparin and related compounds increase the action of antithrombin on thrombin and factor Xa. A newer class of drugs, the direct thrombin inhibitors, is under...
64 KB (6,646 words) - 14:53, 11 May 2025
Rivaroxaban (category Direct Xa inhibitors)
coagulation cascade, inhibiting both thrombin formation and development of thrombi. Rivaroxaban does not inhibit thrombin (activated Factor II), and no effects...
31 KB (2,738 words) - 09:40, 20 May 2025
Heparin (section Mechanism of action)
that have already formed, instead, it prevents clot formation by inhibiting thrombin and other procoagulant serine proteases. Heparin is generally used...
78 KB (7,850 words) - 12:28, 23 May 2025
Venoms in medicine (category Drug discovery)
atrox and Bothrops moojeni, venomous species of pit viper found east of the Andes in South America. It cleaves fibrinogen, similarly to thrombin. Batroxobin...
11 KB (1,302 words) - 19:09, 20 November 2023
Haemophilia (section Scientific discovery)
life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors. Acquired haemophilia...
63 KB (6,932 words) - 17:01, 25 May 2025
free form. These direct factor Xa inhibitors can be administered orally, as can dabigatran etexilate, which is a direct thrombin inhibitor. Fondaparinux...
25 KB (3,112 words) - 19:03, 28 February 2024
Platelet (category CS1 maint: DOI inactive as of November 2024)
"A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation". Journal of Thrombosis and Haemostasis. 11 (5):...
71 KB (8,530 words) - 16:53, 8 May 2025
Aptamer (section Controlled release of therapeutics)
EH, Toole JJ (February 1992). "Selection of single-stranded DNA molecules that bind and inhibit human thrombin". Nature. 355 (6360): 564–566. Bibcode:1992Natur...
62 KB (6,727 words) - 16:56, 23 May 2025
Inflammation (redirect from List of types of inflammation)
infections and diseases, including viral infection, Rickettsia infection, some protozoa, tuberculosis, and some cancers. With the discovery of interleukins...
96 KB (9,751 words) - 10:45, 15 May 2025
Prostaglandin EP3 receptor (category Wikipedia articles incorporating text from the United States National Library of Medicine)
aggregation, degranulation, and blood clot-promoting responsiveness to a wide array of physiological (e.g. thrombin) and pathological (e.g. atheromatous...
37 KB (4,318 words) - 07:29, 25 November 2024
2020). "Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents". European Journal of Medicinal...
25 KB (2,691 words) - 14:31, 23 May 2025
RNA therapeutics (category CS1 maint: DOI inactive as of March 2025)
(November 2012). "Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer". Pharmacology & Therapeutics...
83 KB (9,545 words) - 10:23, 30 March 2025
Nuvelo (category Defunct pharmaceutical companies of the United States)
including acute ischemic stroke and catheter occlusion. NU172, a direct thrombin inhibitor in Phase I development for use as a short-acting anticoagulant...
8 KB (988 words) - 04:16, 5 May 2025
Protein C (category Wikipedia articles in need of updating from October 2024)
of a light chain and a heavy chain connected by a disulfide bond.: 4673 The protein C zymogen is activated when it binds to thrombin, another protein...
47 KB (5,346 words) - 02:39, 28 October 2024
Darexaban (category Direct Xa inhibitors)
Darexaban (YM150) is a direct inhibitor of factor Xa created by Astellas Pharma. It is an experimental drug that acts as an anticoagulant and antithrombotic to...
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Katerina Akassoglou (category National and Kapodistrian University of Athens alumni)
Akassoglou and her team tracked the activity patterns of thrombin and found that thrombin activity in the CNS preceded any sign of disease, and when thrombin activity...
18 KB (1,923 words) - 23:45, 23 May 2025
through guanylate cyclase. COX inhibitors (namely aspirin), warfarin, direct Xa inhibitors, direct thrombin inhibitors, heparin, low-molecular weight...
58 KB (7,309 words) - 06:23, 19 April 2025
Venomics (category Toxic effects of venomous animals)
the direct result of advancements made in proteomic-centered methods and the indirect result of more widely available and cost-effective forms of transcriptomics...
35 KB (3,854 words) - 11:26, 22 May 2025
GNA13 (category Wikipedia articles incorporating text from the United States National Library of Medicine)
proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the National Academy of Sciences of the...
17 KB (1,921 words) - 22:46, 7 May 2025
Medroxyprogesterone acetate (category 3α-Hydroxysteroid dehydrogenase inhibitors)
glucocorticoid activity of MPA may contribute to bone loss. The glucocorticoid activity of MPA may also result in an upregulation of the thrombin receptor in blood...
182 KB (19,038 words) - 17:11, 9 May 2025
Biosensor (redirect from Applications of biosensors)
(toxins or small molecule inhibitors). Such "assays" are commonly used in drug discovery development by pharmaceutical and biotechnology companies. Most...
106 KB (12,175 words) - 22:51, 22 May 2025
fresh frozen plasma, or other blood products such as recombinant anti-thrombin III to achieve adequate anticoagulation. A persistent left superior vena...
34 KB (4,057 words) - 04:58, 2 May 2025
factors in the development of breast cancer" "Blood coagulation, in particular purification of prothrombin and thrombin" "Parkinsons disease and its treatment...
646 KB (30,049 words) - 08:21, 25 May 2025
SOS1 (category Wikipedia articles incorporating text from the United States National Library of Medicine)
"Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction". Proceedings of the National Academy of Sciences...
32 KB (3,595 words) - 10:04, 27 March 2024