• Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various...
    33 KB (3,756 words) - 10:53, 22 April 2025
  • Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin...
    7 KB (821 words) - 09:44, 30 January 2023
  • drugs from the class of direct Xa inhibitors are marketed worldwide. Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially...
    41 KB (4,916 words) - 17:03, 23 September 2024
  • Thumbnail for Hirudin
    Hirudin (category Direct thrombin inhibitors)
    Several other direct thrombin inhibitors are derived chemically from hirudin. Hirudotherapy Discovery and development of direct thrombin inhibitors PDB: 4HTC​...
    7 KB (818 words) - 22:18, 26 June 2024
  • Thumbnail for Thrombin
    antithrombin to thrombin (as well as factor Xa). The direct thrombin inhibitors, a newer class of medication, directly inhibit thrombin by binding to its...
    25 KB (2,932 words) - 18:21, 24 May 2025
  • Thumbnail for Ximelagatran
    Ximelagatran (category Direct thrombin inhibitors)
    Argentina and Brazil). Ximelagatran, a direct thrombin inhibitor, was the first member of this class that can be taken orally. It acts solely by inhibiting the...
    11 KB (972 words) - 19:24, 20 December 2023
  • Thumbnail for Coagulation
    heparin and related compounds increase the action of antithrombin on thrombin and factor Xa. A newer class of drugs, the direct thrombin inhibitors, is under...
    64 KB (6,646 words) - 14:53, 11 May 2025
  • Thumbnail for Rivaroxaban
    Rivaroxaban (category Direct Xa inhibitors)
    coagulation cascade, inhibiting both thrombin formation and development of thrombi. Rivaroxaban does not inhibit thrombin (activated Factor II), and no effects...
    31 KB (2,738 words) - 09:40, 20 May 2025
  • Thumbnail for Heparin
    that have already formed, instead, it prevents clot formation by inhibiting thrombin and other procoagulant serine proteases. Heparin is generally used...
    78 KB (7,850 words) - 12:28, 23 May 2025
  • Venoms in medicine (category Drug discovery)
    atrox and Bothrops moojeni, venomous species of pit viper found east of the Andes in South America. It cleaves fibrinogen, similarly to thrombin. Batroxobin...
    11 KB (1,302 words) - 19:09, 20 November 2023
  • Thumbnail for Haemophilia
    life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors. Acquired haemophilia...
    63 KB (6,932 words) - 17:01, 25 May 2025
  • free form. These direct factor Xa inhibitors can be administered orally, as can dabigatran etexilate, which is a direct thrombin inhibitor. Fondaparinux...
    25 KB (3,112 words) - 19:03, 28 February 2024
  • Thumbnail for Platelet
    Platelet (category CS1 maint: DOI inactive as of November 2024)
    "A critical role of thrombin/PAR-1 in ADP-induced platelet secretion and the second wave of aggregation". Journal of Thrombosis and Haemostasis. 11 (5):...
    71 KB (8,530 words) - 16:53, 8 May 2025
  • Thumbnail for Aptamer
    EH, Toole JJ (February 1992). "Selection of single-stranded DNA molecules that bind and inhibit human thrombin". Nature. 355 (6360): 564–566. Bibcode:1992Natur...
    62 KB (6,727 words) - 16:56, 23 May 2025
  • Thumbnail for Inflammation
    infections and diseases, including viral infection, Rickettsia infection, some protozoa, tuberculosis, and some cancers. With the discovery of interleukins...
    96 KB (9,751 words) - 10:45, 15 May 2025
  • Thumbnail for Prostaglandin EP3 receptor
    Prostaglandin EP3 receptor (category Wikipedia articles incorporating text from the United States National Library of Medicine)
    aggregation, degranulation, and blood clot-promoting responsiveness to a wide array of physiological (e.g. thrombin) and pathological (e.g. atheromatous...
    37 KB (4,318 words) - 07:29, 25 November 2024
  • Thumbnail for Phospholipase C
    2020). "Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents". European Journal of Medicinal...
    25 KB (2,691 words) - 14:31, 23 May 2025
  • RNA therapeutics (category CS1 maint: DOI inactive as of March 2025)
    (November 2012). "Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer". Pharmacology & Therapeutics...
    83 KB (9,545 words) - 10:23, 30 March 2025
  • Nuvelo (category Defunct pharmaceutical companies of the United States)
    including acute ischemic stroke and catheter occlusion. NU172, a direct thrombin inhibitor in Phase I development for use as a short-acting anticoagulant...
    8 KB (988 words) - 04:16, 5 May 2025
  • Thumbnail for Protein C
    Protein C (category Wikipedia articles in need of updating from October 2024)
    of a light chain and a heavy chain connected by a disulfide bond.: 4673  The protein C zymogen is activated when it binds to thrombin, another protein...
    47 KB (5,346 words) - 02:39, 28 October 2024
  • Thumbnail for Darexaban
    Darexaban (category Direct Xa inhibitors)
    Darexaban (YM150) is a direct inhibitor of factor Xa created by Astellas Pharma. It is an experimental drug that acts as an anticoagulant and antithrombotic to...
    9 KB (997 words) - 23:01, 8 November 2023
  • Thumbnail for Katerina Akassoglou
    Katerina Akassoglou (category National and Kapodistrian University of Athens alumni)
    Akassoglou and her team tracked the activity patterns of thrombin and found that thrombin activity in the CNS preceded any sign of disease, and when thrombin activity...
    18 KB (1,923 words) - 23:45, 23 May 2025
  • through guanylate cyclase. COX inhibitors (namely aspirin), warfarin, direct Xa inhibitors, direct thrombin inhibitors, heparin, low-molecular weight...
    58 KB (7,309 words) - 06:23, 19 April 2025
  • Venomics (category Toxic effects of venomous animals)
    the direct result of advancements made in proteomic-centered methods and the indirect result of more widely available and cost-effective forms of transcriptomics...
    35 KB (3,854 words) - 11:26, 22 May 2025
  • Thumbnail for GNA13
    GNA13 (category Wikipedia articles incorporating text from the United States National Library of Medicine)
    proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets". Proceedings of the National Academy of Sciences of the...
    17 KB (1,921 words) - 22:46, 7 May 2025
  • Thumbnail for Medroxyprogesterone acetate
    Medroxyprogesterone acetate (category 3α-Hydroxysteroid dehydrogenase inhibitors)
    glucocorticoid activity of MPA may contribute to bone loss. The glucocorticoid activity of MPA may also result in an upregulation of the thrombin receptor in blood...
    182 KB (19,038 words) - 17:11, 9 May 2025
  • (toxins or small molecule inhibitors). Such "assays" are commonly used in drug discovery development by pharmaceutical and biotechnology companies. Most...
    106 KB (12,175 words) - 22:51, 22 May 2025
  • Thumbnail for Cardiopulmonary bypass
    fresh frozen plasma, or other blood products such as recombinant anti-thrombin III to achieve adequate anticoagulation. A persistent left superior vena...
    34 KB (4,057 words) - 04:58, 2 May 2025
  • factors in the development of breast cancer" "Blood coagulation, in particular purification of prothrombin and thrombin" "Parkinsons disease and its treatment...
    646 KB (30,049 words) - 08:21, 25 May 2025
  • Thumbnail for SOS1
    SOS1 (category Wikipedia articles incorporating text from the United States National Library of Medicine)
    "Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction". Proceedings of the National Academy of Sciences...
    32 KB (3,595 words) - 10:04, 27 March 2024