The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia...

for statin induced rhabdomyolysis include older age, renal impairment, high dose statins and use of medications that reduce the breakdown of statins (such...

take statins live longer in better health". NIHR Evidence. Retrieved 22 January 2025. Brody JE (16 April 2018). "Weighing the Pros and Cons of Statins"....

under this requirement, and some only cover other statins. The drug was billed as a "super-statin" during its clinical development; the claim was that it...

beta blockers and cimetidine, and the discovery of statins by Akira Endo. Another champion of the approach of developing chemical analogues of known active...

7 mg/dL with the use of statins can reduce cardiovascular disease and stroke risk by about 21%. Studies have also found that statins reduce atheroma progression...

taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. Some drugs interact with statins in a...

Biochemist Who Discovered Statins, Akira Endo, Dies At 90: Colleague "Akira Endo obituary: Japanese biochemist whose work led to statins". The Times. 25 June...

and alprazolam Statins: lovastatin, pravastatin, and simvastatin Pharmaceuticals may also be described as "specialty", independent of other classifications...

reducing the risk of cancer. Statins are an important class of cholesterol-lowering drugs; the first generation of statins were derived from fungi. Lovastatin...

(December 2015). "Statins as anti-cancer therapy; Can we translate preclinical and epidemiologic data into clinical benefit?". Discovery Medicine. 20 (112):...

as mevalonate and is of major pharmaceutical importance. Drugs like statins (which lower levels of cholesterol) stop the production of mevalonate by inhibiting...

BEPPU, Teruhiko (ed.). "A historical perspective on the discovery of statins". Proceedings of the Japan Academy, Series B. 86 (5): 484–493. Bibcode:2010PJAB...

brand names: Baycol, Lipobay) is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed...

Azithromycin, however, does not significantly affect the pharmacokinetics of statins and is considered a safer alternative than other macrolide antibiotics....

collectively as the statins, which help treat dyslipidemia. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded...

Heterozygous familial hypercholesterolemia (HeFH) is usually treated with statins. Statins act by inhibiting the enzyme hydroxymethylglutaryl CoA reductase (HMG-CoA-reductase)...

1016/S0022-2275(20)41379-3. PMID 1464741. Endo, Akira (2004). "The origin of the statins". International Congress Series. 1262: 3–8. doi:10.1016/j.ics.2003.12...

retain historical importance to the development of scientific thought and are still being used today. The discovery of microorganisms such as Euglena that...

(January 2022). "Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer". Pharmaceuticals. 15 (2): 151. doi:10...

diabetes, and smoking, are associated with a higher risk of onset and worsened course of AD. The use of statins to lower cholesterol may be of benefit in...

approved and are recommended in patients not receiving enough reduction from their maximally tolerated dose of statins + ezetimibe. Statins reduce high...

of United States discoveries encompasses the breakthroughs of human thought and knowledge of new scientific findings, phenomena, places, things, and what...

the widespread use of anti-cholesterol drugs known as statins, came under criticism from doctors and the National Heart Foundation of Australia. The foundation...

antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human...

include statins used to treat high cholesterol, and protease inhibitors used to treat retroviral infections such as HIV. A common example of an irreversible...

American biopharmaceutical company focused on the discovery, development and commercialization of RNA interference (RNAi) therapeutics for genetically...

with a statin or statin with other lipid-lowering therapies in people unable to reach LDL-C goals with the maximum tolerated dose of a statin, or alone...

A reductase inhibitors (HMG-CoA inhibitors or statins) Statins may sometimes cause myalgia and cramps among other possible side effects. Raloxifene...

cholesterol biosynthesis, and in contrast to triparanol, statins can lower cholesterol levels without resulting in accumulation of intermediates like desmosterol...