A double-strand break repair model refers to the various models of pathways that cells undertake to repair double-strand breaks (DSB). DSB repair is an...

additional error-prone inaccurate repair pathway for double-strand breaks. In MMEJ repair of a double-strand break, an homology of 5–25 complementary...

widely used by cells to accurately repair harmful DNA breaks that occur on both strands of DNA, known as double-strand breaks (DSB), in a process called homologous...

Synthesis-dependent strand annealing (SDSA) is a major mechanism of homology-directed repair of DNA double-strand breaks (DSBs). Although many of the features...

Homology-directed repair (HDR) is a mechanism in cells to repair double-strand DNA lesions. The most common form of HDR is homologous recombination. The...

but also as a mechanism for repair of double-strand breaks (DSBs) caused by DNA damage. These DSBs are usually repaired using the sister chromatid of...

Rothstein, Rodney J.; Stahl, Franklin W. (May 1983). "The double-strand-break repair model for recombination". Cell. 33 (1): 25–35. doi:10.1016/0092-8674(83)90331-8...

T. L. Orr-Weaver, R. J. Rothstein and F.W. Stahl, 1983 The double-strand-break repair model for recombination. Cell 33: 25-35. Foss, E., R. Lande, F. W...

may specifically repair double-strand breaks (i.e. a break in both complementary strands of DNA). Single-strand breaks are repaired by DNA ligase using...

complementary sequence analogous to double-strand-break repair. The filament searches for the homologous chromosome, strand invasion occurs where the new chromosome...

distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4". DNA Repair (Amst.). 3 (11): 1493–502. doi:10.1016/j.dnarep...

of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex binds avidly to double-strand breaks...

eukaryotes, two primary models for how homologous recombination repairs double-strand breaks in DNA are the double-strand break repair (DSBR) pathway (sometimes...

intramolecular double helix, which mimicks DNA double-strand break lesions. In the event of a double-stranded break in the genome, the cell most commonly repairs the...

performed by the protein RecA. During meiosis, repair of double-strand damages, particularly double-strand breaks, occurs by the recombination process outlined...

LF (September 2003). "Regulation and mechanisms of mammalian double-strand break repair". Oncogene. 22 (37): 5792–812. doi:10.1038/sj.onc.1206679. PMID 12947387...

recombination: two different routes for double-strand break repair: the different functions of meiotic versus mitotic DSB repair are reflected in different pathway...

template strands to form two double helical DNA molecules. Multiple experiments were conducted to determine how DNA replicates. The semiconservative model was...

made up of a double helix of two complementary strands. DNA is often called double helix. The double helix describes the appearance of a double-stranded DNA...

"Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair". Current Genomics. 10 (4): 250–258. doi:10.2174/138920209788488544...

PMID 23545420. Jackson, Stephen P. (2002-05-01). "Sensing and repairing DNA double-strand breaks". Carcinogenesis. 23 (5): 687–696. doi:10.1093/carcin/23.5...

functions in pathways to repair double-strand breaks in DNA, and in the repair of "crosslink" damage that harmfully links the two DNA strands. Cells with disabling...

the error-free repair of DNA double-strand breaks. If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this...

cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks. If BRCA1...

(see figure). These enzymes repair the double-strand breaks within about 15 minutes to 2 hours. The double-strand breaks in the promoter are thus associated...

chromosomes by preventing DNA repair systems from mistaking the very ends of the DNA strand for a double-strand break. The existence of a special structure...

insertions, deletions, and base-to-base conversions without the need for double strand breaks (DSBs) or donor DNA templates. The technology has received mainstream...

acids. It has also been known to cause DNA double-strand breaks. Accumulation of DNA double strand breaks can lead to cell cycle arrest in somatic cells...

(TALENs) provided an easier way to target a double-stranded break to a specific location on the DNA strand. Both zinc finger nucleases and TALENs require...

double-strand-breaks, which cleaves the DNA. Since only a small number of double-strand breaks are tolerated, and only a small number can be repaired...