The Endothelium-derived relaxing factor (EDRF) is a strong vasodilator produced by cardiac endothelial cells in response to stress signals such as high...
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In blood vessels Endothelium-Derived Hyperpolarizing Factor or EDHF is proposed to be a substance and/or electrical signal that is generated or synthesized...
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activation Endothelial microparticle Endothelial progenitor cell Endothelium-derived relaxing factor (EDRF) Robert F. Furchgott (1998 Nobel prize for discovery...
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Nitric oxide Endothelial nitric oxide synthase Prostacyclin Endothelium-derived relaxing factor Endothelin Integrin network Endothelial shear stress Marchio...
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Platelet (redirect from Platelet derived factors)
"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor". Nature. 327 (6122): 524–6. Bibcode:1987Natur.327..524P...
71 KB (8,529 words) - 10:45, 12 July 2025
The most prominent vasodilator is nitric oxide (termed endothelium-derived relaxing factor for this reason). The circulatory system uses the channel...
24 KB (2,571 words) - 05:56, 11 July 2025
properties of nitric oxide were the same as those seen in the endothelium derived relaxing factor (EDRF) previously identified by Robert Furchgott three years...
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advantageous because of their endothelial cells, which produce endothelium-derived relaxing factor and prostacyclin, protecting the artery from atherosclerosis...
50 KB (6,261 words) - 06:58, 3 March 2025
bacteria, plants, fungi, and animal cells. Nitric oxide, an endothelium-derived relaxing factor (EDRF), is biosynthesized endogenously from L-arginine, oxygen...
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HELLP syndrome (section Risk factors)
alongside the decreased release of the endothelium-derived relaxing factor and increased the release of von Willebrand factor (vWF), leading to general activation...
33 KB (3,742 words) - 22:30, 13 April 2025
endothelial cells that relaxes blood vessels, calling it endothelium-derived relaxing factor (EDRF). By 1986, he had worked out EDRF's nature and mechanism...
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Smooth muscle (section Inducing stimuli and factors)
muscle can be mediated by the endothelium-derived relaxing factor-nitric oxide, endothelial derived hyperpolarizing factor (either an endogenous cannabinoid...
37 KB (4,737 words) - 17:18, 22 January 2025
showed that the occurrence was mediated by what they called endothelium-derived relaxing factor, later found to be nitric oxide, and it was shortly shown...
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Murad, M.D., PhD, professor of medicine, discovered that endothelium-derived relaxing factor is nitric oxide, which acts as a vasodilator by stimulating...
39 KB (2,852 words) - 17:30, 25 April 2025
Vascular resistance (section Other factors)
causes release of endothelium-derived relaxing factor (EDRF) (later it was discovered that EDRF was nitric oxide) from intact endothelium, causing vasodilation...
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by supplementing blood concentrations of NO, also called endothelium-derived relaxing factor, before the structure of NO as the responsible agent was...
26 KB (2,633 words) - 05:16, 26 June 2025
the endothelium-derived relaxing factor produced in response to shear from increased blood flow in arteries. This dilates blood vessels by relaxing smooth...
31 KB (3,605 words) - 14:48, 24 May 2025
synthase and the formation of nitric oxide (NO), also known as 'endothelium-derived relaxing factor', or 'EDRF'. Nitric oxide is critical to blood vessel function...
12 KB (1,233 words) - 20:06, 7 May 2021
coronary arteries showed that nitric oxide was the long sought endothelium-derived relaxing factor. After scientists realised that NO played a biological role...
24 KB (2,686 words) - 14:10, 23 May 2025
Cardiff, directed by Prof. Andrew Henderson, researching the Endothelium-derived relaxing factor (EDRF, later identified as nitric oxide). He received a Young...
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vasodilation of the venous capacitance vessels by stimulating the endothelium-derived relaxing factor (EDRF). Used to relieve both exertional and vasospastic angina...
8 KB (1,035 words) - 11:28, 6 March 2024
(pGC) receptor, and nitric oxide (NO), identified as the endothelium-derived relaxing factor, was shown to activate soluble guanylyl cyclase (sGC), producing...
21 KB (2,132 words) - 07:37, 15 July 2025
EDH epidural hematoma EDM esophageal Doppler monitor EDRF endothelium-derived relaxing factor aka nitric oxide EDTA ethylene-diamine-tetraacetic acid EDS...
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peripheral circulation and organs. A reduced release of endothelium derived relaxing factor (EDRF) causes a decrease in the stimulation of guanylate...
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Keaney JF, Hunt NH, Stocker R (2010). "Kynurenine is an endothelium-derived relaxing factor produced during inflammation". Nature Medicine. 16 (3): 279–85...
22 KB (2,133 words) - 21:02, 22 May 2025
"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor". Nature. 327 (6122): 524–6. Bibcode:1987Natur.327..524P...
18 KB (1,733 words) - 01:34, 19 June 2025
this leads to the release of nitric oxide (also called endothelium-derived relaxing factor), natriuresis and diuresis (the production and elimination...
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contributed to the understanding of endothelium-dependent relaxation of blood vessels (endothelium-derived relaxing factor), the identification of the enzymes...
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research emerged in 1980 when NO was first known as the 'endothelium-derived relaxing factor' (EDRF). The identity of EDRF as actually being NO was revealed...
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lining (endothelium) of a large blood vessel controlled underlying vascular smooth muscle cells by releasing endothelium-derived relaxing factor, later...
14 KB (1,329 words) - 09:29, 7 November 2023