• Thumbnail for Exosome component 5
    Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex. Biallelic pathogenic variation in EXOSC5 causes autosomal...
    9 KB (971 words) - 05:46, 19 July 2025
  • Thumbnail for Exosome component 1
    protein 46. Exosome component 1 has been shown to interact with: Exosome component 5, Exosome component 6, and Exosome component 7. GRCh38: Ensembl release...
    7 KB (782 words) - 05:46, 19 July 2025
  • Thumbnail for Exosome component 8
    Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex. Exosome component 8 has been shown...
    6 KB (614 words) - 17:16, 16 July 2025
  • Thumbnail for Exosome component 10
    Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which (sometimes called PM/Scl-100) is part of the exosome complex...
    7 KB (858 words) - 17:16, 16 July 2025
  • Thumbnail for Exosome component 7
    Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex. Exosome component 7 has been shown...
    6 KB (717 words) - 04:09, 15 July 2025
  • Thumbnail for Exosome component 2
    Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. Mammalian mRNAs contain AU-rich elements (AREs)...
    8 KB (1,045 words) - 16:32, 17 July 2025
  • Thumbnail for Exosome component 9
    Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which (sometimes called RRP45 or PM/Scl-75) is part of the exosome...
    8 KB (797 words) - 05:46, 19 July 2025
  • Thumbnail for Exosome component 4
    Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex. Exosome component 4 has been shown to interact with...
    6 KB (777 words) - 05:46, 19 July 2025
  • Thumbnail for Exosome component 6
    the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. Exosome component 6 has been shown to interact with Exosome component...
    4 KB (516 words) - 17:16, 16 July 2025
  • Thumbnail for Exosome component 3
    Exosome component 3, also known as EXOSC3, is a human gene, which is part of the exosome complex. Mutations in EXOSC3 cause pontocerebellar hypoplasia...
    6 KB (702 words) - 21:41, 15 July 2025
  • Thumbnail for Exosome complex
    The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of...
    43 KB (4,589 words) - 17:33, 6 November 2024
  • Thumbnail for Complement component 5
    Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved...
    9 KB (1,114 words) - 04:01, 15 July 2025
  • agreed to acquire Quad Technologies. In August 2018, the company acquired Exosome Diagnostics for $250 million plus up to an additional $325 million in milestone...
    12 KB (826 words) - 07:17, 31 August 2024
  • Thumbnail for Serum amyloid P component
    The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein first identified as the pentagonal...
    6 KB (744 words) - 18:35, 16 July 2025
  • Thumbnail for Telomerase RNA component
    PARN, and subsequent 3’-5’ exoribonucleolytic degradation. Extended hTR transcripts are also degraded by the RNA exosome. The 5’ ends of hTR transcripts...
    23 KB (2,549 words) - 18:46, 16 July 2025
  • Thumbnail for TRAMP complex
    the core exosome down to 4-5 adenosines assisting in transcript recognition and exosome complex activation. The substrate specificity of exosomes is improved...
    19 KB (2,325 words) - 20:23, 15 May 2025
  • Autoantibodies often found in these patients are the anti-PM/Scl (anti-exosome) antibodies. The symptoms that are seen most often are typical symptoms...
    6 KB (597 words) - 04:26, 20 June 2025
  • Thumbnail for Complement component 2
    system and the Complement component 2 protein attaches to Complement system 4 resulting in an immune response. Complement component 2 protein is critical...
    16 KB (2,068 words) - 16:58, 16 July 2025
  • Thumbnail for Complement component 4B
    Complement component 4B (Chido blood group) is a kind of the Complement component 4 protein that in humans is encoded by the C4B gene. This gene encodes...
    8 KB (1,049 words) - 05:28, 19 July 2025
  • Thumbnail for Complement component 3
    Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the...
    15 KB (1,758 words) - 16:58, 16 July 2025
  • Thumbnail for Keratin 5
    Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate...
    22 KB (2,682 words) - 06:15, 19 July 2025
  • Thumbnail for Complement component 6
    Complement component 6 is a protein that in humans is encoded by the C6 gene. Complement component 6 is a protein involved in the complement system. It...
    7 KB (910 words) - 04:01, 15 July 2025
  • Thumbnail for Complement component 9
    Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system. Once activated, about 12-18...
    7 KB (789 words) - 20:10, 20 January 2025
  • Thumbnail for DIS3L2
    encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible...
    1 KB (153 words) - 04:05, 15 July 2025
  • Thumbnail for MTAP
    S-methyl-5'-thioadenosine phosphorylase (MTAP) is an enzyme responsible for polyamine metabolism. In humans, it is encoded by the methylthioadenosine...
    24 KB (2,538 words) - 17:30, 17 July 2025
  • D (June 2005). "RNA degradation by the exosome is promoted by a nuclear polyadenylation complex". Cell. 121 (5): 713–24. doi:10.1016/j.cell.2005.04.029...
    57 KB (7,094 words) - 23:56, 6 August 2024
  • base pairs, a 5' cap, poly-adenylated tail, and rapid degradation due to the combined activity of poly-adenylating polymerases and exosome complexes. CUT...
    18 KB (2,296 words) - 10:27, 5 January 2024
  • Thumbnail for Complement component 1s
    Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system...
    10 KB (1,195 words) - 16:58, 16 July 2025
  • Thumbnail for Integrin beta 5
    Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene. Integrin, beta 5 has been shown to interact with PTK2, Annexin A5 and PAK4. ITGB5...
    10 KB (1,273 words) - 17:00, 17 July 2025
  • Thumbnail for Microvesicle
    to be larger, on average, than intracellularly-generated EVs known as exosomes. Microvesicles play a role in intercellular communication and can transport...
    54 KB (6,074 words) - 21:14, 22 May 2025