Isopenicillin N synthase (IPNS) is a non-heme iron protein belonging to the 2-oxoglutarate (2OG)-dependent dioxygenases oxidoreductase family. This enzyme...
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the bicyclic intermediate isopenicillin N by isopenicillin N synthase (IPNS), which is encoded by the gene pcbC. Isopenicillin N is a very weak intermediate...
100 KB (10,792 words) - 13:08, 10 July 2025
cyclizations by a single enzyme) to bicyclic intermediate isopenicillin N by isopenicillin N synthase (IPNS) to form the penam core structure. Various transamidations...
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High-valent iron (section Fe(IV)N)
model biological complexes such as cytochrome P450, NO synthase, and isopenicillin N synthase. Two such reported compounds are thiolate-ligated oxoiron(IV)...
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examples are the lipoxygenases, isopenicillin N synthase, protocatechuate 3,4-dioxygenase, deacetoxycephalosporin-C synthase, and aromatic amino acid hydroxylases...
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Christianson LM, Powers ML, Haddock SH (30 June 2015). "Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine...
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αKG-dependent dioxygenase that is involved in oxygen sensing, and isopenicillin N synthase (IPNS), a microbial αKG-dependent dioxygenase. Given the important...
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eventually culminating in the determination of the crystal structure of isopenicillin N synthase" 2002 Nicholas Handy "for his pioneering contributions to the development...
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deiodinase EC 1.21.1.1 Category:EC 1.21.3 Isopenicillin N synthase EC 1.21.3.1 Tetrahydrocannabinolic acid synthase EC 1.21.3.7 Category:EC 1.21.4 Category:EC...
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Philosophy degree at University of Oxford on Mechanistic studies on isopenicillin N synthase and successfully completed it in 1985. His PhD was supervised by...
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enzymology, a deacetoxycephalosporin-C synthase (EC 1.14.20.1) is an enzyme that catalyzes the chemical reaction penicillin N + 2-oxoglutarate + O2 ⇌ {\displaystyle...
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Schofield, CJ; Baldwin, JE (1995-06-22). "Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes". Nature....
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Peter J. (15 June 2003). "Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cys...
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metabolites including polyketide synthase, terpenes, chetomin, rotiorinols A-C, "multidrug resistance protein", isopenicillin N synthase and related dioxygenases...
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(azurin) EC 1.20.99.1: arsenate reductase (donor) EC 1.21.3.1: isopenicillin-N synthase EC 1.21.3.2: columbamine oxidase EC 1.21.3.3: reticuline oxidase...
199 KB (24,465 words) - 11:27, 23 June 2025
synthetase, pcbC encodes isopenicillinN (IPN) synthase, and penDE, encoding acyl-CoA:isopenicillinN acyltransferase. The high penicillin-producing...
24 KB (2,599 words) - 08:15, 15 July 2025
2-aminohexano-6-lactam racemase EC 5.1.1.16: protein-serine epimerase EC 5.1.1.17: isopenicillin-N epimerase EC 5.1.1.18: serine racemase EC 5.1.1.20: L-Ala-D/L-Glu epimerase...
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O-acetyltransferase EC 2.3.1.164: isopenicillin-N N-acyltransferase EC 2.3.1.165: 6-methylsalicylic acid synthase EC 2.3.1.166: 2α-hydroxytaxane 2-O-benzoyltransferase...
216 KB (21,690 words) - 11:59, 23 June 2025