• Thumbnail for Isopenicillin N synthase
    Isopenicillin N synthase (IPNS) is a non-heme iron protein belonging to the 2-oxoglutarate (2OG)-dependent dioxygenases oxidoreductase family. This enzyme...
    10 KB (929 words) - 17:28, 20 January 2025
  • Thumbnail for Penicillin
    the bicyclic intermediate isopenicillin N by isopenicillin N synthase (IPNS), which is encoded by the gene pcbC. Isopenicillin N is a very weak intermediate...
    100 KB (10,792 words) - 13:08, 10 July 2025
  • Thumbnail for Β-Lactam antibiotic
    cyclizations by a single enzyme) to bicyclic intermediate isopenicillin N by isopenicillin N synthase (IPNS) to form the penam core structure. Various transamidations...
    34 KB (3,707 words) - 01:09, 4 July 2025
  • Thumbnail for High-valent iron
    model biological complexes such as cytochrome P450, NO synthase, and isopenicillin N synthase. Two such reported compounds are thiolate-ligated oxoiron(IV)...
    10 KB (1,299 words) - 20:25, 10 April 2025
  • Thumbnail for Non-heme iron protein
    examples are the lipoxygenases, isopenicillin N synthase, protocatechuate 3,4-dioxygenase, deacetoxycephalosporin-C synthase, and aromatic amino acid hydroxylases...
    3 KB (258 words) - 06:01, 9 November 2023
  • Thumbnail for Coelenterazine
    Christianson LM, Powers ML, Haddock SH (30 June 2015). "Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine...
    9 KB (744 words) - 14:15, 2 July 2025
  • αKG-dependent dioxygenase that is involved in oxygen sensing, and isopenicillin N synthase (IPNS), a microbial αKG-dependent dioxygenase. Given the important...
    36 KB (3,995 words) - 12:05, 1 July 2025
  • Thumbnail for Leverhulme Medal (Royal Society)
    eventually culminating in the determination of the crystal structure of isopenicillin N synthase" 2002 Nicholas Handy "for his pioneering contributions to the development...
    12 KB (528 words) - 05:53, 21 January 2025
  • deiodinase EC 1.21.1.1 Category:EC 1.21.3 Isopenicillin N synthase EC 1.21.3.1 Tetrahydrocannabinolic acid synthase EC 1.21.3.7 Category:EC 1.21.4 Category:EC...
    33 KB (3,650 words) - 22:24, 27 March 2025
  • Philosophy degree at University of Oxford on Mechanistic studies on isopenicillin N synthase and successfully completed it in 1985. His PhD was supervised by...
    14 KB (1,057 words) - 09:46, 17 June 2025
  • enzymology, a deacetoxycephalosporin-C synthase (EC 1.14.20.1) is an enzyme that catalyzes the chemical reaction penicillin N + 2-oxoglutarate + O2 ⇌ {\displaystyle...
    4 KB (389 words) - 23:19, 11 July 2025
  • Thumbnail for Janos Hajdu (biophysicist)
    Schofield, CJ; Baldwin, JE (1995-06-22). "Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes". Nature....
    30 KB (2,724 words) - 15:12, 22 May 2025
  • Peter J. (15 June 2003). "Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cys...
    41 KB (4,207 words) - 23:26, 26 May 2025
  • metabolites including polyketide synthase, terpenes, chetomin, rotiorinols A-C, "multidrug resistance protein", isopenicillin N synthase and related dioxygenases...
    21 KB (2,474 words) - 01:02, 27 May 2025
  • (azurin) EC 1.20.99.1: arsenate reductase (donor) EC 1.21.3.1: isopenicillin-N synthase EC 1.21.3.2: columbamine oxidase EC 1.21.3.3: reticuline oxidase...
    199 KB (24,465 words) - 11:27, 23 June 2025
  • Thumbnail for Penicillium rubens
    synthetase, pcbC encodes isopenicillinN (IPN) synthase, and penDE, encoding acyl-CoA:isopenicillinN acyltransferase. The high penicillin-producing...
    24 KB (2,599 words) - 08:15, 15 July 2025
  • 2-aminohexano-6-lactam racemase EC 5.1.1.16: protein-serine epimerase EC 5.1.1.17: isopenicillin-N epimerase EC 5.1.1.18: serine racemase EC 5.1.1.20: L-Ala-D/L-Glu epimerase...
    29 KB (3,229 words) - 08:21, 23 June 2025
  • O-acetyltransferase EC 2.3.1.164: isopenicillin-N N-acyltransferase EC 2.3.1.165: 6-methylsalicylic acid synthase EC 2.3.1.166: 2α-hydroxytaxane 2-O-benzoyltransferase...
    216 KB (21,690 words) - 11:59, 23 June 2025