In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down...

One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a loading dose. A loading dose is most useful...

treatment with a myocardial infarction with ST-elevation including A loading dose given in advance of percutaneous coronary intervention (PCI), followed...

exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time. Dose–response relationships can be described by dose–response...

140 mg/kg loading dose followed by 70 mg/kg every four hours for 17 more doses, and if the patient vomits within 1 hour of dose, the dose must be repeated...

daily over two to three months. In another proposed cholecalciferol loading dose guideline for vitamin D-deficient adults, a weekly dosage is given, up...

or low-dose intravenous, subcutaneous or intramuscular (e.g. the "Alberti regime") insulin, potassium supplementation, need for a loading dose of insulin...

taking a lower dose of 3 grams a day for 28 days can also increase total muscle creatine storage to the same amount as the rapid loading dose of 20 g/day...

Patients with severe vitamin D deficiency will require treatment with a loading dose; its magnitude can be calculated based on the actual serum 25-hydroxy-vitamin...

aggregation was about 70% following three to five days of dosing at 10 mg daily after a 60-mg loading dose. Platelet aggregation gradually returns to baseline...

prasugrel and ticagrelor are given concurrently, also as a loading dose, with the dose depending on whether further surgical management or fibrinolysis...

useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or...

measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in...

May be provoked by increased heart rate. Exercise stress tests after loading. Dose dependent. Follow bradycardia, prolonged QT closely. Roden DM (August...

with low volume distribution (vancomycin, teicoplanin, colistin), a loading dose is required to achieve an adequate therapeutic level to fight infections...

500 mg/month by intramuscular injection (and a single additional 500 mg loading dose on day 15 of therapy) in postmenopausal women with advanced breast cancer...

amiodarone, elimination t⁠1/2⁠ of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly. Many drugs follow...

doses may cause first-degree or second-degree atrioventricular block. These adverse events usually occur briefly after administering a loading dose of...

blood plasma. In other words, it is the ratio of amount of drug in a body (dose) to concentration of the drug that is measured in blood, plasma, and un-bound...

suppress secretion of thyroxine from the thyroid gland. The dose typically begins with a loading dose, then 1⁄3 mL SSKI (5 drops or 250 mg iodine as iodide)...

Dosing generally applies to feeding chemicals or medicines when used in small quantities. For medicines the term dose is generally used. In the case of...

vortioxetine (area-under-the-curve levels after a single dose versus at steady state) is 5 to 6. A loading dose given intravenously has been found to achieve steady-state...

adult dose usually ranges from 12 to 24 grams. When administered in continuous infusion, a loading dose of fosfomycin 8 g followed by a daily dose of 16 g...

Standard doses of all antibiotics were employed in these studies, with minocycline being administered orally or IV as a 200 mg loading dose followed by...

voriconazole, and amphotericin B failed; caspofungin 50 mg/day after a loading dose of 70 mg intravenously was also unsuccessful. Amphotericin B, introduced...

quinolones in preventing deaths in severe or complicated malaria. Quinine loading dose helps to shorten the duration of fever and increases parasite clearance...

community-acquired, lower respiratory tract infections, sparfloxacin (200 or 400 mg loading dose then 100 or 200 mg daily; i.e. 200/100 mg and 400/200 mg) had a similar...

directly after the stenting procedure, commonly in the form of an immediate loading dose of the potent anticoagulant (blood thinner) plavix administered as a...

oral loading dose. Consider using decreased maintenance dose. Kidney disease: Do not use oral loading dose. Can begin with standard maintenance dose and...

practice the curve is generally nearer to a parabola due to the weight of the load (i.e. the road) being much larger than the cables themselves, and in calculations...