MHC multimers are oligomeric forms of MHC molecules, designed to identify and isolate T-cells with high affinity to specific antigens amid a large group...
20 KB (2,386 words) - 02:12, 8 November 2024
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell...
58 KB (6,779 words) - 13:56, 9 May 2025
analysis. Incubation of MHC-Strep-tag fusion proteins with the Strep-Tactin backbone results in the formation of a MHC-multimer, which is capable for antigen-specific...
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with tetramers: a practical guide to staining T cells with peptide-MHC multimers". Immunology. 146 (1): 11–22. doi:10.1111/imm.12499. PMC 4552497. PMID 26076649...
11 KB (1,224 words) - 05:47, 26 March 2025
thereby initiate the MAPK cascade. B-cell receptor Co-stimulation ImmTAC MHC multimer IMGT Kindt TJ, Goldsby RA, Osborne BA, Kuby J (2007). Kuby immunology...
44 KB (5,378 words) - 07:54, 5 May 2025
protein. Synthetic pentameric proteins include MHC pentamers, a type of MHC multimer, comprising five peptide-MHC complexes associated via a coiled-coil domain...
3 KB (286 words) - 18:54, 20 January 2025
applicable to many different antigen-specific T cells. The MHC Dextramers are fluorescent MHC multimer reagents, developed for sensitive, specific and accurate...
13 KB (1,413 words) - 13:21, 19 August 2022
and can be linked to streptavidin in a defined orientation e.g. for MHC multimers. Enzymatic biotinylation is most often carried out by E. coli biotin...
23 KB (2,941 words) - 22:42, 13 March 2025
antigen-stimulated cell proliferation and cytokine release, staining with peptide-MHC multimers or using an activation-induced marker (AIM) assay. Many invertebrates...
24 KB (2,961 words) - 23:06, 22 March 2025
Outline of immunology (section MHCs)
Genetically modified mouse Immunofluorescence Immunofixation Immunoadsorption MHC multimer Hybridoma technology Rabbit hybridoma Developmental studies hybridoma...
38 KB (2,656 words) - 20:26, 6 November 2024
Schmidt, B.; Bernhard, H.; Wagner, H.; Busch, D. H. (2002). "Reversible MHC multimer staining for functional isolation of T-cell populations and effective...
15 KB (1,473 words) - 21:46, 21 June 2024
protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These...
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Major histocompatibility complex Mannan-binding lectin MHC class I MHC class II MHC multimer MHC restriction Microantibody Microbial symbiosis and immunity...
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CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression...
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carried by the blood. Receptors are complex proteins or tightly bound multimer of proteins, located in the plasma membrane or within the interior of the...
61 KB (6,651 words) - 16:01, 2 May 2025
first studies that detected SARS-CoV-2-specific CD8+ T cells using MHC class I multimers. In addition, he demonstrated that SARS-CoV-2-specific T cell memory...
17 KB (1,897 words) - 19:10, 8 May 2025
gag and env in a similar manner as the HIV Rev protein. Rev binds as a multimer to the Rev Response Element (RRE) which has a stem-loop secondary structure...
30 KB (3,765 words) - 02:44, 1 April 2025
of substrates to monomers of LAMP-2A triggers the assembly of LAMP-2A multimers that act as the active translocation complex through which the substrates...
31 KB (3,623 words) - 00:33, 22 June 2024
forming a PML-Nuclear body (PML-NB). The edge of the ring-like protein multimer features protein threads that extend out from the ring and make contact...
33 KB (4,053 words) - 07:02, 10 July 2024
and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers". Blood. 106 (13): 4199–209. doi:10.1182/blood-2005-05-2111. PMC 1895236...
42 KB (4,614 words) - 10:42, 5 February 2025
sequence. The ORF8ab protein has also been reported to form disulfide-linked multimers. The full-length SARS-CoV ORF8ab protein is post-translationally modified...
18 KB (1,870 words) - 14:55, 10 January 2024
WC, Yen TJ, Yoda K, Masumoto H, et al. (November 2000). "Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes"...
9 KB (979 words) - 06:33, 6 May 2024