A mineralocorticoid receptor antagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid...

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is...

potassium levels. The effects of mineralocorticoids are mediated by slow genomic mechanisms through nuclear receptors as well as by fast nongenomic mechanisms...

acute symptoms of heart failure, the role of diuretics in the mineralocorticoid receptor antagonists’ class such as spironolactone is to reduce mortality...

associated with type 2 diabetes. Finerenone is a non-steroidal mineralocorticoid receptor antagonist. It is taken orally (swallowed by mouth). Common side...

potassium (K+) levels. It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. It...

concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in...

Amlodipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid. Amlodipine has been studied in...

spirolactone group and a selective aldosterone receptor antagonist (SARA). Eplerenone and other mineralocorticoid receptor antagonists have been demonstrated to...

Corticosteroids act as agonists of the glucocorticoid receptor and/or the mineralocorticoid receptor.[citation needed] In addition to their corticosteroid...

ACE inhibitors, calcium channel blockers, beta blockers, and angiotensin receptor blockers is employed, but does not have a proven benefit in HFpEF patients...

additional therapies such as ACE inhibitors, angiotensin II receptor blockers, mineralocorticoid receptor antagonists, and inotropes may be utilized. Despite...

Membrane mineralocorticoid receptors (mMRs) or membrane aldosterone receptors are a group of receptors which bind and are activated by mineralocorticoids such...

blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which...

Estrogen receptor-β (ERβ; NR3A2, ESR2) Group C: 3-Ketosteroid receptors 1: Glucocorticoid receptor (GR; NR3C1) (Cortisol) 2: Mineralocorticoid receptor (MR;...

pregnancy is safe for the fetus is unknown. Fludrocortisone is mostly a mineralocorticoid, but it also has glucocorticoid effects. Fludrocortisone was patented...

Nimodipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid. The key acetoacetate (2) for...

Felodipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid. Different calcium channels are...

receptor. Glucocorticoid receptor has been shown to interact with: BAG1, CEBPB, CREBBP, DAP3, DAXX, HSP90AA1, HNRPU, MED1, MED14, Mineralocorticoid receptor...

Both aldosterone and cortisol have a similar affinity for the mineralocorticoid receptor; however, there is vastly more cortisol in circulation than aldosterone...

Grossmann C (July 2017). "30 Years of the Mineralocorticoid Receptor: Nongenomic effects via the mineralocorticoid receptor". The Journal of Endocrinology. 234...

antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid...

functions are carried out by cortisol binding to glucocorticoid or mineralocorticoid receptors inside a cell, which then bind to DNA to affect gene expression...

methylprednisolone has a higher affinity to glucocorticoid receptors than to mineralocorticoid receptors. Glucocorticoid's name was derived after the discovery...

affinity to the progesterone receptor (PR) and mineralocorticoid receptor (MR), with lower affinity to the androgen receptor (AR), and with very low affinity...

the treatment of hypertension. Aldosterone receptor antagonists, also known as mineralocorticoid receptor antagonist (MRA) can lower blood pressure by...

very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor. Mometasone, like other corticosteroids...

angiotensin II receptor blockers (ARBs), or angiotensin receptor-neprilysin inhibitors, along with beta blockers, mineralocorticoid receptor antagonists...

Nifedipine has additionally been found to act as an antagonist of the mineralocorticoid receptor, or as an antimineralocorticoid. Nifedipine (initially BAY a1040...

experimental selective mineralocorticoid receptor modulator developed by AstraZeneca for heart failure. Compared to mineralocorticoid receptor antagonists, it...