A point accepted mutation — also known as a PAM — is the replacement of a single amino acid in the primary structure of a protein with another single...

substitution matrices include the blocks substitution (BLOSUM) and point accepted mutation (PAM) matrices. Both are based on taking sets of high-confidence...

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain...

biomedicine Pneumatic artificial muscles, used in artificial limbs Point accepted mutation, a type of similarity matrix in computational biology Positive...

bases. One of the first amino acid substitution matrices, the PAM (Point Accepted Mutation) matrix was developed by Margaret Dayhoff in the 1970s. This matrix...

ancestor, mismatches can be interpreted as point mutations and gaps as indels (that is, insertion or deletion mutations) introduced in one or both lineages in...

databases. She originated one of the first substitution matrices, point accepted mutations (PAM). The one-letter code used for amino acids was developed by...

BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these...

A splice site mutation is a genetic mutation that inserts, deletes or changes a number of nucleotides in the specific site at which splicing takes place...

A behaviour mutation is a genetic mutation that alters genes that control the way in which an organism behaves, causing their behavioural patterns to change...

Western-developed modern breeds. It is a form of partial albinism resulting from a mutation that affects tyrosinase, an enzyme involved with melanin production. The...

variants originate, de Vries developed a mutation theory that led to a temporary rift between those who accepted Darwinian evolution and biometricians who...

exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously...

Opinions vary as to whether this trait might be the result of genetic mutation or merely an instinctive reaction from being picked up as kittens by their...

of a normal cat's tail. This is the result of a cat body type genetic mutation affecting the tail development, similar to that of a Manx cat. The breed...

often dubbed the Himalayan; and hair-mutation breeds, including the Cornish Rex, Sphynx, Peterbald, and blue-point Siamese cat. The long-haired Siamese...

tail must not exceed three inches from the point of extension to the tailbone. See also Cat body-type mutation: Tail types Recent scientific studies on...

distinctive breed of domestic cat characterised by a natural dominant gene mutation associated with osteochondrodysplasia. This genetic anomaly affects cartilage...

and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer...

(2014) Biased polyphenism in polydactylous cats carrying a single point mutation: the Hemingway model for of digit novelty. Evolutionary Biology, 41...

support (or disprove) the idea of adaptive mutation, at least in microorganisms. The most widely accepted theory of evolution states that organisms are...

random mutations on an individual solution. A mutation that increases fitness is always accepted. A mutation that lowers fitness is accepted probabilistically...

phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed...

sequence and mechanism of TATA box initiation, mutations such as insertions, deletions, and point mutations to this consensus sequence can result in phenotypic...

the body. It is an autosomal recessive disease resulting from various mutations of gene CYP19 (P450arom) which can lead to ambiguous genitalia and delayed...

syndrome is due to a genetic mutation in the MECP2 gene, on the X chromosome. It almost always occurs as a new mutation, with less than one percent of...

Siamese-style point coloration and sapphire-blue eyes. The Balinese is also known as the purebred long-haired Siamese since it originated as a natural mutation of...

effects of two beneficial mutations in the same individual (i.e. sex aids in the spread of advantageous traits) without the mutations having to have occurred...

This algorithm has been used to discover disease-causing splice site mutations and cryptic splice sites. A splice site is the border between an exon...

which offered no mechanism for evolution. Mutationism did propose a mechanism, but it was not generally accepted. The modern synthesis a generation later...