In molecular biology, prostanoids are active lipid mediators that regulate inflammatory response. Prostanoids are a subclass of eicosanoids consisting...

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for...

forming PGH2. PGH2 is the parent prostanoid to all other prostanoids. It is metabolized by (see diagram in Prostanoid): a) The prostaglandin E synthase...

proliferation of various human cancer cell lines in culture. Prostanoids and Prostaglandin receptors Prostanoids are prostaglandins (PG), thromboxanes (TX), and prostacyclins...

The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor...

including a 5-carbon ring. They are a subclass of eicosanoids and of the prostanoid class of fatty acid derivatives. The structural differences between prostaglandins...

but generally with lesser affinity and responsiveness to certain other prostanoids (see Prostaglandin receptors). Animal model studies have implicated EP1...

lesser extent PGE2 at concentrations close to those of PGF2α. Standard prostanoids have the following relative efficacies as receptor ligands in binding...

but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP4 has been implicated in various physiological...

Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost, is a naturally occurring prostaglandin used in medicine to induce...

but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological...

and DP2. Among the 8 human prostanoid receptors, DP1, along with IP, EP2, and EP4, are classified as relaxant prostanoid receptors; each, including DP1...

the vascular network on endothelium and smooth muscle cells. Standard prostanoids have the following relative efficacies as receptor ligands in binding...

increases body temperature, resulting in fever. PGE2 is also a predominant prostanoid that contributes to inflammation via enhancing edema and leukocyte infiltration...

and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological...

García Rodríguez LA (July 2001). "Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs"...

SM, Brahim JS, Rowan J, Kent A, Dionne RA (August 2002). "Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: replicate clinical...

I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme...

Fukano Y, Kawazu K (August 2009). "Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to...

(prostaglandin I2) in eicosanoid nomenclature, and is a member of the prostanoids (together with the prostaglandins and thromboxane). PGI2, derived primarily...

Sharif NA, Odani-Kawabata N, Lu F, Pinchuk L (April 2023). "FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating...

little or no such amino acid sequence relationship to the eight other Prostanoid receptors (see Eicosanoid receptor#Prostenoid receptors). DP2 was found...

family of isozymes, EC 1.14.99.1) that is responsible for biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from...

inhibitor of thromboxane synthase and an antagonist of the thromboxane prostanoid receptor. It was developed for diabetic nephropathy. Kim, Yoon Kook; Ning...

v t e Prostanoid signaling modulators Receptor (ligands) Enzyme (inhibitors) Others Precursors: Linoleic acid γ-Linolenic acid (gamolenic acid) Dihomo-γ-linolenic...

by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis (PGE2) within the hypothalamus. PGE2 signals to the hypothalamus...

v t e Prostanoid signaling modulators Receptor (ligands) Enzyme (inhibitors) Others Precursors: Linoleic acid γ-Linolenic acid (gamolenic acid) Dihomo-γ-linolenic...

ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo". Basic & Clinical Pharmacology...

v t e Prostanoid signaling modulators Receptor (ligands) Enzyme (inhibitors) Others Precursors: Linoleic acid γ-Linolenic acid (gamolenic acid) Dihomo-γ-linolenic...

and modifies the enzymatic activity of COX-2. COX-2 normally produces prostanoids, most of which are proinflammatory. Aspirin-modified COX-2 (aka...