contributed an understanding of protein folding and structure mediated by hydrophobic interactions. The first protein to have its amino acid chain sequenced...

Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical...

Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...

Protein biosynthesis, or protein synthesis, is a core biological process, occurring inside cells, balancing the loss of cellular proteins (via degradation...

native structure of a protein. Tertiary structure of a protein involves a single polypeptide chain; however, additional interactions of folded polypeptide...

non-covalent interactions, such as hydrogen bonding, ionic interactions, Van der Waals forces, and hydrophobic packing. To understand the functions of proteins at...

affects a large portion of proteins. Even if a protein is not phosphorylated itself, its interactions with other proteins may be regulated by phosphorylation...

G-protein activation. However, the possibility for interaction does allow for G-protein-independent signaling to occur. There are three main G-protein-mediated...

biology research in order to track protein interactions in real time. The first fluorescent tag, green fluorescent protein (GFP), was isolated from Aequorea...

Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions...

website. Biology portal Protein design Protein function prediction Protein–protein interaction prediction Gene prediction Protein structure prediction software...

activator like effectors. Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held...

Protein–protein interactions can be designed using protein design algorithms because the principles that rule protein stability also rule protein–protein binding...

chromosome stability, its interaction with the cellular transcriptome, its interaction with other cytoskeletal or synaptic proteins, its involvement in myelination...

Protein–protein interaction screening refers to the identification of Protein–protein interaction with high-throughput screening methods such as computer-...

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...

Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside...

In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest...

p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription...

In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently...

The green fluorescent protein (GFP) is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range. The label GFP...

between a protein and a functional, proteinaceous unit was difficult to elucidate. More recently, people refer to protein–protein interaction when discussing...

Der Waals Interactions) and protein-solvent interactions. As a result, this process is heavily reliant on environmental state that the protein resides in...

molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a...

heat shock proteins function as intra-cellular chaperones for other proteins. They play an important role in protein–protein interactions such as folding...

A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic...

microfilaments or microtubules. Actin-based motor proteins (myosin) move along microfilaments through interaction with actin, and microtubule motors (dynein...

assembly of multi-protein complexes by increasing the probability of any appropriate protein–protein interactions. Peripheral membrane proteins may interact...

Antifreeze proteins (AFPs) or ice structuring proteins refer to a class of polypeptides produced by certain animals, plants, fungi and bacteria that permit...

Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being...