• In biochemistry, a rate-limiting step is a reaction step that controls the rate of a series of biochemical reactions. The statement is, however, a misunderstanding...
    11 KB (1,402 words) - 17:28, 13 October 2024
  • rate-limiting step. For a given reaction mechanism, the prediction of the corresponding rate equation (for comparison with the experimental rate law)...
    12 KB (1,736 words) - 20:02, 2 September 2024
  • In biochemistry, control coefficients are used to describe how much influence a given reaction step has on the flux or concentration of the species at...
    6 KB (959 words) - 03:33, 25 February 2025
  • Thumbnail for Committed step
    the rate-limiting step, which is the step with the highest flux control coefficient. It is rare that the first committed step is in fact the rate-determining...
    7 KB (675 words) - 22:45, 17 February 2025
  • steady state is maintained by balancing the rate of substrate provided by a previous step and the rate that the substrate is converted into product,...
    14 KB (1,894 words) - 19:18, 22 November 2023
  • Thumbnail for Citric acid cycle
    Citric acid cycle (category Exercise biochemistry)
    phosphoenolpyruvate by phosphoenolpyruvate carboxykinase, which is the rate limiting step in the conversion of nearly all the gluconeogenic precursors (such...
    55 KB (6,095 words) - 01:17, 25 May 2025
  • Thumbnail for Tryptophan 2,3-dioxygenase
    of L-tryptophan (L-Trp) to N-formyl-L-kynurenine, as the first and rate-limiting step of the kynurenine pathway. L-tryptophan + O2 ⇌ N-formyl-L-kynurenine...
    18 KB (2,094 words) - 14:33, 9 September 2023
  • Thumbnail for Michaelis–Menten kinetics
    is often written as V max {\displaystyle V_{\max }} , represents the limiting rate approached by the system at saturating substrate concentration for a...
    47 KB (6,248 words) - 13:53, 26 May 2025
  • Thumbnail for Enzyme kinetics
    pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction". Journal of...
    72 KB (9,551 words) - 07:46, 27 March 2025
  • Thumbnail for Nitrification
    bacteria. The transformation of ammonia to nitrite is usually the rate limiting step of nitrification. Nitrification is an aerobic process performed by...
    42 KB (4,996 words) - 03:40, 15 June 2025
  • Thumbnail for Kinetic isotope effects of RuBisCO
    RuBP then loses a proton to form a reactive, enodiolate species. The rate-limiting step of the Calvin-Benson cycle is the addition of CO2 to this 2,3-enediol...
    21 KB (2,412 words) - 11:33, 18 August 2023
  • Thumbnail for Metabolic control analysis
    Metabolic control analysis (category Biochemistry methods)
    systems theory Control coefficient (biochemistry) Flux (metabolism) Moiety conservation Rate-limiting step (biochemistry) Fell D., (1997) Understanding the...
    29 KB (4,523 words) - 22:03, 20 June 2025
  • Thumbnail for 10-Formyltetrahydrofolate
    Robert E. MacKenzie (1998). "Methenyltetrahydrofolate Cyclohydrolase Is Rate Limiting for the Enzymatic Conversion of 10-Formyltetrahydrofolate to 5...
    4 KB (233 words) - 17:07, 31 July 2023
  • considered to be located at one point only, called the master reaction or rate limiting step. The summation theorem suggests this does not necessarily have to...
    13 KB (2,091 words) - 18:29, 3 December 2023
  • Thumbnail for Branched pathways
    also means that in this situation, there can be more than one Rate-limiting step (biochemistry) in a pathway. Unlike a linear pathway, values for C e 3 J...
    15 KB (2,885 words) - 23:00, 23 May 2025
  • Thumbnail for Phosphoenolpyruvic acid
    enzyme phosphoenolpyruvate carboxykinase (PEPCK). This reaction is a rate-limiting step in gluconeogenesis: GTP + oxaloacetate → GDP + phosphoenolpyruvate...
    6 KB (384 words) - 16:02, 30 May 2025
  • of the polymerase to the template is the rate-limiting step in DNA synthesis[citation needed], the overall rate of DNA replication during S phase of the...
    6 KB (826 words) - 20:25, 10 September 2023
  • Thumbnail for RuBisCO
    primary rate-limiting factor of the Calvin cycle during the day. Nevertheless, under most conditions, and when light is not otherwise limiting photosynthesis...
    59 KB (6,522 words) - 15:43, 23 May 2025
  • Thumbnail for Activation energy
    Activation energy (category Biochemistry terminology)
    overall rate constant k for a two-step reaction A ⇌ B, B → C is given by k = k2K1, where k2 is the rate constant of the rate-limiting slow second step and...
    19 KB (2,166 words) - 23:34, 15 June 2025
  • Thumbnail for Aconitase
    exactly this flip occurs is debatable. One theory is that, in the rate-limiting step of the mechanism, the cis-aconitate is released from the enzyme, then...
    15 KB (1,527 words) - 12:48, 27 May 2025
  • the substrate is the chemical of interest that is being modified. In biochemistry, an enzyme substrate is the material upon which an enzyme acts. When...
    14 KB (1,616 words) - 22:15, 29 May 2025
  • Thumbnail for Pyridoxine 5′-phosphate oxidase
    metabolism pathway. Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B6 metabolism, the biosynthesis of pyridoxal 5′-phosphate...
    12 KB (1,439 words) - 17:57, 21 September 2024
  • Thumbnail for Phosphorylation
    freely permeable to glucose, and the initial rate of phosphorylation of glucose is the rate-limiting step in glucose metabolism by the liver. The liver's...
    17 KB (1,860 words) - 18:28, 27 June 2025
  • Thumbnail for Tryptophan hydroxylase
    amino acid 5-hydroxytryptophan (5-HTP), which is the initial and rate-limiting step in the synthesis of the neurotransmitter serotonin. It is also the...
    10 KB (890 words) - 05:27, 16 December 2024
  • Thumbnail for Glycolysis
    to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) which is the rate limiting step controlling the synthesis of cholesterol. Cholesterol can be used as...
    82 KB (8,731 words) - 04:57, 2 June 2025
  • Gluconeogenesis (category Exercise biochemistry)
    the rate-limiting step of gluconeogenesis. Glucose-6-phosphate is formed from fructose 6-phosphate by phosphoglucoisomerase (the reverse of step 2 in...
    33 KB (3,700 words) - 18:29, 22 June 2025
  • Thumbnail for HMG-CoA reductase
    (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-limiting enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of...
    34 KB (4,113 words) - 17:46, 24 May 2025
  • Thumbnail for Lipolysis
    acids and glycerol. Each step of hydrolysis leads to the removal of one fatty acid. The first step and the rate-limiting step of lipolysis is carried out...
    15 KB (1,555 words) - 06:29, 15 June 2025
  • Thumbnail for Aminolevulinic acid synthase
    ALAS2 catalyze the first step in the process of heme synthesis. It is the first irreversible step and is also rate limiting. This means that the beginning...
    10 KB (1,308 words) - 19:05, 13 February 2024
  • Thumbnail for Acetyl-CoA
    Acetyl-CoA (category Biochemistry articles needing expert attention)
    acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) which is the rate-limiting step controlling the synthesis of cholesterol. Cholesterol can be used...
    27 KB (2,577 words) - 06:37, 24 June 2025